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Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice.
J Ethnopharmacol. 2015 Feb 23; 161:92-8.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Penthorum chinense Pursh (Penthoraceae) has been used as a Miao ethnomedicine for the treatment of jaundice, cholecystitis, edema, infectious hepatitis and anti-drunk hangover in China. The aim of present study is to investigate the possible protective effects of Penthorum chinense against chronic ethanol-induced liver injury.

MATERIAL AND METHODS

Mice were fed a Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin as control diet with or without aqueous extract of Penthorum chinense (PCP, 5.15 and 10.30 g/kg/BW) for 4 weeks. Silymarin (86 mg/kg) was used as positive control to compare the efficacy of PCP against chronic ethanol-induced hepatotoxicity.

RESULTS

Treatment with PCP (10.30 g/kg) significantly reduced the increases in serum ALT and AST levels, hepatic lipid accumulation and inflammatory cytokines (i.e. TNF-α, IL-6), which were induced by chronic ethanol exposure. PCP was also found to attenuate reactive oxygen species (ROS) generation and malondialdehyde (MDA) level, restore the glutathione (GSH) depletion, and increase the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. In addition, PCP supplementation (10.30 g/kg) inhibited the induction of hepatic cytochrome P450 2E1 (CYP2E1), a major contributor to ethanol-mediated oxidative stress, and up-regulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream anti-oxidant protein heme oxygenase-1 (HO-1) in ethanol-treated mice.

CONCLUSIONS

These results indicate that the co-treatment with aqueous extract of Penthorum chinense (10.30 g/kg) protects against chronic ethanol-induced liver injury, possibly through suppressing CYP2E1-mediated oxidative stress and enhancing the oxidant defense systems via the activation of Nrf2/HO-1 pathway.

Authors+Show Affiliations

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.Sichuan New Lotus Traditional Chinese Herb Limited Company, Chengdu, China.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, China.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. Electronic address: jbwan@umac.mo.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25510733

Citation

Cao, Yi-Wei, et al. "Protective Effects of Penthorum Chinense Pursh Against Chronic Ethanol-induced Liver Injury in Mice." Journal of Ethnopharmacology, vol. 161, 2015, pp. 92-8.
Cao YW, Jiang Y, Zhang DY, et al. Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice. J Ethnopharmacol. 2015;161:92-8.
Cao, Y. W., Jiang, Y., Zhang, D. Y., Wang, M., Chen, W. S., Su, H., Wang, Y. T., & Wan, J. B. (2015). Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice. Journal of Ethnopharmacology, 161, 92-8. https://doi.org/10.1016/j.jep.2014.12.013
Cao YW, et al. Protective Effects of Penthorum Chinense Pursh Against Chronic Ethanol-induced Liver Injury in Mice. J Ethnopharmacol. 2015 Feb 23;161:92-8. PubMed PMID: 25510733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice. AU - Cao,Yi-Wei, AU - Jiang,Yun, AU - Zhang,Da-Yong, AU - Wang,Meng, AU - Chen,Wan-Sheng, AU - Su,Huanxing, AU - Wang,Yi-Tao, AU - Wan,Jian-Bo, Y1 - 2014/12/12/ PY - 2014/07/03/received PY - 2014/11/20/revised PY - 2014/12/04/accepted PY - 2014/12/17/entrez PY - 2014/12/17/pubmed PY - 2015/10/7/medline KW - Alcoholic liver disease KW - Ethanol-induced liver injury KW - Oxidant defense system KW - Oxidative stress KW - Penthorum chinense Pursh SP - 92 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 161 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Penthorum chinense Pursh (Penthoraceae) has been used as a Miao ethnomedicine for the treatment of jaundice, cholecystitis, edema, infectious hepatitis and anti-drunk hangover in China. The aim of present study is to investigate the possible protective effects of Penthorum chinense against chronic ethanol-induced liver injury. MATERIAL AND METHODS: Mice were fed a Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin as control diet with or without aqueous extract of Penthorum chinense (PCP, 5.15 and 10.30 g/kg/BW) for 4 weeks. Silymarin (86 mg/kg) was used as positive control to compare the efficacy of PCP against chronic ethanol-induced hepatotoxicity. RESULTS: Treatment with PCP (10.30 g/kg) significantly reduced the increases in serum ALT and AST levels, hepatic lipid accumulation and inflammatory cytokines (i.e. TNF-α, IL-6), which were induced by chronic ethanol exposure. PCP was also found to attenuate reactive oxygen species (ROS) generation and malondialdehyde (MDA) level, restore the glutathione (GSH) depletion, and increase the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. In addition, PCP supplementation (10.30 g/kg) inhibited the induction of hepatic cytochrome P450 2E1 (CYP2E1), a major contributor to ethanol-mediated oxidative stress, and up-regulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream anti-oxidant protein heme oxygenase-1 (HO-1) in ethanol-treated mice. CONCLUSIONS: These results indicate that the co-treatment with aqueous extract of Penthorum chinense (10.30 g/kg) protects against chronic ethanol-induced liver injury, possibly through suppressing CYP2E1-mediated oxidative stress and enhancing the oxidant defense systems via the activation of Nrf2/HO-1 pathway. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/25510733/Protective_effects_of_Penthorum_chinense_Pursh_against_chronic_ethanol_induced_liver_injury_in_mice_ DB - PRIME DP - Unbound Medicine ER -