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[Mesectodermal leiomyoma. Unusual tumor of the ciliary body].
Cir Cir 2014 Jan-Feb; 82(1):70-5CC

Abstract

BACKGROUND

Mesectodermal leiomyoma is a benign tumor of smooth muscle of the ciliary body, which is derived from the neural crest.

CLINICAL CASE

We report the case of a 35-year-old Mexican woman with visually impaired and blurred vision of the right eye of 2 months duration. The clinical and imaging presuntional diagnosis was adenoma of the non pigmented epithelium of the ciliary body and it was surgically resected. Microscopically, the tumor was composed of cells with round nuclei and scant cytoplasm without atypia or mitosis, arranged in a fibrillary background. The immunohistochemical markers for vimentin, muscle specific actin, smooth muscle actin and calponin were strongly positive in the cytoplasm of the neoplastic cells, while for glial fibrillary acidic protein and S-100 protein were negative in the same cellular population.

CONCLUSIONS

Mesectodermal leiomyoma of the ciliary body is benign tumor of smooth muscle extremely rare in this location. Until now, there are just 25 previous reported cases in the literature and, the main differential diagnosis is uveal malignant melanoma, therefore some eyes were enucleated. The ultrabiomicroscopy, A and B-scan imaging studies are useful in the evaluation, however, is mandatory the microsocpic examination with routine and histochemical stains as well as the use of immunohistochemical markers such as vimentin, specific muscle actin, smooth muscle actin andcalponin to stablish the smooth muscle origin of this neoplasm, and rule out other malignant neoplams such as malignant melanoma.

Authors+Show Affiliations

Departamento de oftalmología, Hospital Regional ISSSTE Lic. Adolfo López Mateos, Mexico.Departamento de oftalmología, Hospital Regional ISSSTE Lic. Adolfo López Mateos, Mexico.Departamento de oftalmología, Hospital Regional ISSSTE Lic. Adolfo López Mateos, Mexico.División de Investigación, Hospital Juárez de México, Mexico.Servicio de Patología Oftálmica, Asociación para Evitar la Ceguera en México IAP. Hospital Dr. Luis Sánchez Bulnes, Mexico DF, Mexico. arodri2@yahoo.com.

Pub Type(s)

Case Reports
Journal Article
Review

Language

spa

PubMed ID

25510793

Citation

Rentería-Ruiz, Nancy Paulina, et al. "[Mesectodermal Leiomyoma. Unusual Tumor of the Ciliary Body]." Cirugia Y Cirujanos, vol. 82, no. 1, 2014, pp. 70-5.
Rentería-Ruiz NP, de Wit-Carter G, Villaseñor-Diez J, et al. [Mesectodermal leiomyoma. Unusual tumor of the ciliary body]. Cir Cir. 2014;82(1):70-5.
Rentería-Ruiz, N. P., de Wit-Carter, G., Villaseñor-Diez, J., Flores-Estrada, J. J., & Rodríguez-Reyes, A. A. (2014). [Mesectodermal leiomyoma. Unusual tumor of the ciliary body]. Cirugia Y Cirujanos, 82(1), pp. 70-5.
Rentería-Ruiz NP, et al. [Mesectodermal Leiomyoma. Unusual Tumor of the Ciliary Body]. Cir Cir. 2014;82(1):70-5. PubMed PMID: 25510793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mesectodermal leiomyoma. Unusual tumor of the ciliary body]. AU - Rentería-Ruiz,Nancy Paulina, AU - de Wit-Carter,Guillermo, AU - Villaseñor-Diez,Jaime, AU - Flores-Estrada,José Javier, AU - Rodríguez-Reyes,Abelardo Antonio, PY - 2014/12/17/entrez PY - 2014/12/17/pubmed PY - 2015/8/21/medline KW - Mesectodermal leiomyoma KW - ciliary body KW - cuerpo ciliar KW - immunohistochemistry KW - inmunohistoquímica KW - leiomioma mesectodérmico SP - 70 EP - 5 JF - Cirugia y cirujanos JO - Cir Cir VL - 82 IS - 1 N2 - BACKGROUND: Mesectodermal leiomyoma is a benign tumor of smooth muscle of the ciliary body, which is derived from the neural crest. CLINICAL CASE: We report the case of a 35-year-old Mexican woman with visually impaired and blurred vision of the right eye of 2 months duration. The clinical and imaging presuntional diagnosis was adenoma of the non pigmented epithelium of the ciliary body and it was surgically resected. Microscopically, the tumor was composed of cells with round nuclei and scant cytoplasm without atypia or mitosis, arranged in a fibrillary background. The immunohistochemical markers for vimentin, muscle specific actin, smooth muscle actin and calponin were strongly positive in the cytoplasm of the neoplastic cells, while for glial fibrillary acidic protein and S-100 protein were negative in the same cellular population. CONCLUSIONS: Mesectodermal leiomyoma of the ciliary body is benign tumor of smooth muscle extremely rare in this location. Until now, there are just 25 previous reported cases in the literature and, the main differential diagnosis is uveal malignant melanoma, therefore some eyes were enucleated. The ultrabiomicroscopy, A and B-scan imaging studies are useful in the evaluation, however, is mandatory the microsocpic examination with routine and histochemical stains as well as the use of immunohistochemical markers such as vimentin, specific muscle actin, smooth muscle actin andcalponin to stablish the smooth muscle origin of this neoplasm, and rule out other malignant neoplams such as malignant melanoma. SN - 2444-054X UR - https://www.unboundmedicine.com/medline/citation/25510793/[Mesectodermal_leiomyoma__Unusual_tumor_of_the_ciliary_body]_ DB - PRIME DP - Unbound Medicine ER -