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BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development.
Gene Expr Patterns 2015; 17(1):16-25GE

Abstract

Sutures, where neighboring craniofacial bones are separated by undifferentiated mesenchyme, are major growth sites during craniofacial development. Pathologic fusion of bones within sutures occurs in a wide variety of craniosynostosis conditions and can result in dysmorphic craniofacial growth and secondary neurologic deficits. Our knowledge of the genes involved in suture formation is poor. Here we describe the novel expression pattern of the BCL11B transcription factor protein during murine embryonic craniofacial bone formation. We examined BCL11B protein expression at E14.5, E16.5, and E18.5 in 14 major craniofacial sutures of C57BL/6J mice. We found BCL11B expression to be associated with all intramembranous craniofacial bones examined. The most striking aspects of BCL11B expression were its high levels in suture mesenchyme and increasingly complementary expression with RUNX2 in differentiating osteoblasts during development. BCL11B was also expressed in mesenchyme at the non-sutural edges of intramembranous bones. No expression was seen in osteoblasts involved in endochondral ossification of the cartilaginous cranial base. BCL11B is expressed to potentially regulate the transition of mesenchymal differentiation and suture formation within craniofacial intramembranous bone.

Authors+Show Affiliations

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: gregory.holmes@mssm.edu.Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25511173

Citation

Holmes, Greg, et al. "BCL11B Expression in Intramembranous Osteogenesis During Murine Craniofacial Suture Development." Gene Expression Patterns : GEP, vol. 17, no. 1, 2015, pp. 16-25.
Holmes G, van Bakel H, Zhou X, et al. BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development. Gene Expr Patterns. 2015;17(1):16-25.
Holmes, G., van Bakel, H., Zhou, X., Losic, B., & Jabs, E. W. (2015). BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development. Gene Expression Patterns : GEP, 17(1), pp. 16-25. doi:10.1016/j.gep.2014.12.001.
Holmes G, et al. BCL11B Expression in Intramembranous Osteogenesis During Murine Craniofacial Suture Development. Gene Expr Patterns. 2015;17(1):16-25. PubMed PMID: 25511173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development. AU - Holmes,Greg, AU - van Bakel,Harm, AU - Zhou,Xueyan, AU - Losic,Bojan, AU - Jabs,Ethylin Wang, Y1 - 2014/12/12/ PY - 2014/10/24/received PY - 2014/11/26/revised PY - 2014/12/03/accepted PY - 2014/12/17/entrez PY - 2014/12/17/pubmed PY - 2015/10/23/medline KW - Bone KW - Calvaria KW - Ctip2 KW - Differentiation KW - Osteoblasts KW - Skull SP - 16 EP - 25 JF - Gene expression patterns : GEP JO - Gene Expr. Patterns VL - 17 IS - 1 N2 - Sutures, where neighboring craniofacial bones are separated by undifferentiated mesenchyme, are major growth sites during craniofacial development. Pathologic fusion of bones within sutures occurs in a wide variety of craniosynostosis conditions and can result in dysmorphic craniofacial growth and secondary neurologic deficits. Our knowledge of the genes involved in suture formation is poor. Here we describe the novel expression pattern of the BCL11B transcription factor protein during murine embryonic craniofacial bone formation. We examined BCL11B protein expression at E14.5, E16.5, and E18.5 in 14 major craniofacial sutures of C57BL/6J mice. We found BCL11B expression to be associated with all intramembranous craniofacial bones examined. The most striking aspects of BCL11B expression were its high levels in suture mesenchyme and increasingly complementary expression with RUNX2 in differentiating osteoblasts during development. BCL11B was also expressed in mesenchyme at the non-sutural edges of intramembranous bones. No expression was seen in osteoblasts involved in endochondral ossification of the cartilaginous cranial base. BCL11B is expressed to potentially regulate the transition of mesenchymal differentiation and suture formation within craniofacial intramembranous bone. SN - 1872-7298 UR - https://www.unboundmedicine.com/medline/citation/25511173/BCL11B_expression_in_intramembranous_osteogenesis_during_murine_craniofacial_suture_development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-133X(14)00126-4 DB - PRIME DP - Unbound Medicine ER -