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Intestinal permeability as a measure of small intestinal mucosal integrity: correlation with jejunal biopsy.
Afr J Med Med Sci. 1989 Sep; 18(3):187-92.AJ

Abstract

The permeability of the small intestine was measured and jejunal biopsy performed in 39 children with gastrointestinal disorders. Intestinal permeability was measured using orally administered mannitol and lactulose as probe molecules in an isotonic solution (274 mOs/l), and the results were expressed as the ratio of the urinary excretion of the two sugars over 5 h. Urine samples were analysed for mannitol and lactulose content by high performance liquid chromatography. Children with small intestinal mucosal damage, irrespective of the cause, had a significantly lower (P less than 0.001) mannitol excretion (mean recovery 1.21% of ingested dose) than those with a normal mucosa (mean recovery 5.3%), while lactulose excretion did not differ (P greater than 0.05). The mean value of the lactulose:mannitol urinary excretion ratios was significantly higher (P less than 0.001) in subjects with an abnormal mucosa (0.98) compared to those with a normal mucosa (0.2). Using the mean plus two standard deviations of the normal mucosa group to define the upper limit of normal, all lactulose: mannitol excretion ratios from the abnormal mucosa group were above this limit. The results of this study show that the sugar permeability test is a sensitive, non-invasive screening test for jejunal mucosal damage in children and shows good correlation with jejunal biopsy results.

Authors+Show Affiliations

Institute of Child Health, University of Birmingham, U.K.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2551159

Citation

Akinbami, F O., et al. "Intestinal Permeability as a Measure of Small Intestinal Mucosal Integrity: Correlation With Jejunal Biopsy." African Journal of Medicine and Medical Sciences, vol. 18, no. 3, 1989, pp. 187-92.
Akinbami FO, Brown GA, McNeish AS. Intestinal permeability as a measure of small intestinal mucosal integrity: correlation with jejunal biopsy. Afr J Med Med Sci. 1989;18(3):187-92.
Akinbami, F. O., Brown, G. A., & McNeish, A. S. (1989). Intestinal permeability as a measure of small intestinal mucosal integrity: correlation with jejunal biopsy. African Journal of Medicine and Medical Sciences, 18(3), 187-92.
Akinbami FO, Brown GA, McNeish AS. Intestinal Permeability as a Measure of Small Intestinal Mucosal Integrity: Correlation With Jejunal Biopsy. Afr J Med Med Sci. 1989;18(3):187-92. PubMed PMID: 2551159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal permeability as a measure of small intestinal mucosal integrity: correlation with jejunal biopsy. AU - Akinbami,F O, AU - Brown,G A, AU - McNeish,A S, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 187 EP - 92 JF - African journal of medicine and medical sciences JO - Afr J Med Med Sci VL - 18 IS - 3 N2 - The permeability of the small intestine was measured and jejunal biopsy performed in 39 children with gastrointestinal disorders. Intestinal permeability was measured using orally administered mannitol and lactulose as probe molecules in an isotonic solution (274 mOs/l), and the results were expressed as the ratio of the urinary excretion of the two sugars over 5 h. Urine samples were analysed for mannitol and lactulose content by high performance liquid chromatography. Children with small intestinal mucosal damage, irrespective of the cause, had a significantly lower (P less than 0.001) mannitol excretion (mean recovery 1.21% of ingested dose) than those with a normal mucosa (mean recovery 5.3%), while lactulose excretion did not differ (P greater than 0.05). The mean value of the lactulose:mannitol urinary excretion ratios was significantly higher (P less than 0.001) in subjects with an abnormal mucosa (0.98) compared to those with a normal mucosa (0.2). Using the mean plus two standard deviations of the normal mucosa group to define the upper limit of normal, all lactulose: mannitol excretion ratios from the abnormal mucosa group were above this limit. The results of this study show that the sugar permeability test is a sensitive, non-invasive screening test for jejunal mucosal damage in children and shows good correlation with jejunal biopsy results. SN - 0309-3913 UR - https://www.unboundmedicine.com/medline/citation/2551159/Intestinal_permeability_as_a_measure_of_small_intestinal_mucosal_integrity:_correlation_with_jejunal_biopsy_ DB - PRIME DP - Unbound Medicine ER -