TY - JOUR T1 - Relevance of the anti-inflammatory properties of curcumin in neurodegenerative diseases and depression. AU - Tizabi,Yousef, AU - Hurley,Laura L, AU - Qualls,Zakiya, AU - Akinfiresoye,Luli, Y1 - 2014/12/12/ PY - 2014/10/21/received PY - 2014/12/05/revised PY - 2014/12/08/accepted PY - 2014/12/17/entrez PY - 2014/12/17/pubmed PY - 2015/9/1/medline SP - 20864 EP - 79 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 19 IS - 12 N2 - This review is an attempt to summarize our current understanding of curcumin's potential as a neuroprotectant and an antidepressant. This dual property confers a unique advantage to this herbal medication, believed to be devoid of any major side effects, to combat commonly observed co-morbid conditions of a neurodegenerative and a neuropsychiatric disorder. Moreover, in line with the theme of this series, the role of inflammation and stress in these diseases and possible anti-inflammatory effects of curcumin, as well as its interaction with signal transduction proteins as a common denominator in its varied mechanisms of action, are also discussed. Thus, following a brief introduction of curcumin's pharmacology, we present research suggesting how its anti-inflammatory properties have therapeutic potential in treating a devastating neurological disorder (Parkinson's disease = PD) and a debilitating neuropsychiatric disorder (major depressive disorder = MDD). It is concluded that curcumin, or better yet, an analog with better and longer bioavailability could be of important therapeutic potential in PD and/or major depression. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/25514226/Relevance_of_the_anti_inflammatory_properties_of_curcumin_in_neurodegenerative_diseases_and_depression_ DB - PRIME DP - Unbound Medicine ER -