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Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC.
BMC Complement Altern Med. 2014 Dec 16; 14:503.BC

Abstract

BACKGROUND

Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase (IDO) was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products.

METHODS

In this in vitro study, interferences of lavender oil and constituents (-)-linalool, (+)-α-pinene and (+)-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate (GTP)-cyclohydrolase-I and of interferon-γ have been investigated using unstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC).

RESULTS

Treatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-γ was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced.

CONCLUSION

Data from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria. dietmar.fuchs@i-med.ac.at.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25515049

Citation

Gostner, Johanna M., et al. "Lavender Oil Suppresses Indoleamine 2,3-dioxygenase Activity in Human PBMC." BMC Complementary and Alternative Medicine, vol. 14, 2014, p. 503.
Gostner JM, Ganzera M, Becker K, et al. Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC. BMC Complement Altern Med. 2014;14:503.
Gostner, J. M., Ganzera, M., Becker, K., Geisler, S., Schroecksnadel, S., Überall, F., Schennach, H., & Fuchs, D. (2014). Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC. BMC Complementary and Alternative Medicine, 14, 503. https://doi.org/10.1186/1472-6882-14-503
Gostner JM, et al. Lavender Oil Suppresses Indoleamine 2,3-dioxygenase Activity in Human PBMC. BMC Complement Altern Med. 2014 Dec 16;14:503. PubMed PMID: 25515049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC. AU - Gostner,Johanna M, AU - Ganzera,Markus, AU - Becker,Kathrin, AU - Geisler,Simon, AU - Schroecksnadel,Sebastian, AU - Überall,Florian, AU - Schennach,Harald, AU - Fuchs,Dietmar, Y1 - 2014/12/16/ PY - 2014/01/10/received PY - 2014/12/09/accepted PY - 2014/12/18/entrez PY - 2014/12/18/pubmed PY - 2015/9/5/medline SP - 503 EP - 503 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 14 N2 - BACKGROUND: Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase (IDO) was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products. METHODS: In this in vitro study, interferences of lavender oil and constituents (-)-linalool, (+)-α-pinene and (+)-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate (GTP)-cyclohydrolase-I and of interferon-γ have been investigated using unstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC). RESULTS: Treatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-γ was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced. CONCLUSION: Data from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/25515049/Lavender_oil_suppresses_indoleamine_23_dioxygenase_activity_in_human_PBMC_ L2 - https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-503 DB - PRIME DP - Unbound Medicine ER -