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Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects.
Invest Ophthalmol Vis Sci. 2014 Dec 16; 56(1):372-81.IO

Abstract

PURPOSE

We studied the correlation between outer nuclear layer (ONL) thickness and cone density in normal eyes and eyes with retinitis pigmentosa (RP).

METHODS

Spectral-domain optical coherence tomography (SD-OCT) scans were acquired using a displaced pupil entry position of the scanning beam to distinguish Henle's fiber layer from the ONL in 20 normal eyes (10 subjects) and 12 eyes with RP (7 patients). Cone photoreceptors were imaged using adaptive optics scanning laser ophthalmoscopy. The ONL thickness and cone density were measured at 0.5° intervals along the horizontal meridian through the fovea nasally and temporally. The ONL thickness and cone density were correlated using Spearman's rank correlation coefficient r.

RESULTS

Cone densities averaged over the central 6° were lower in eyes with RP than normal, but showed high variability in both groups. The ONL thickness and cone density were significantly correlated when all retinal eccentricities were combined (r = 0.74); the correlation for regions within 0.5° to 1.5° eccentricity was stronger (r = 0.67) than between 1.5° and 3.0° eccentricity (r = 0.23). Although cone densities were lower between 0.5° and 1.5° in eyes with RP, ONL thickness measures at identical retinal locations were similar in the two groups (P = 0.31), and interindividual variation was high for ONL and cone density measures. Although ONL thickness and retinal eccentricity were important predictors of cone density, eccentricity was over 3 times more important.

CONCLUSIONS

The ONL thickness and cone density were correlated in normal eyes and eyes with RP, but both were strongly correlated with retinal eccentricity, precluding estimation of cone density from ONL thickness. (ClinicalTrials.gov number, NCT00254605.).

Authors+Show Affiliations

Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States.School of Optometry and Vision Science Graduate Group, University of California, Berkeley, Berkeley, California, United States West Coast Retina Medical Group, San Francisco, California, United States.Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States.Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States.Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States F.I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, San Francisco, California, United States.School of Optometry and Vision Science Graduate Group, University of California, Berkeley, Berkeley, California, United States.Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.School of Optometry and Vision Science Graduate Group, University of California, Berkeley, Berkeley, California, United States.Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25515570

Citation

Menghini, Moreno, et al. "Correlation of Outer Nuclear Layer Thickness With Cone Density Values in Patients With Retinitis Pigmentosa and Healthy Subjects." Investigative Ophthalmology & Visual Science, vol. 56, no. 1, 2014, pp. 372-81.
Menghini M, Lujan BJ, Zayit-Soudry S, et al. Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects. Invest Ophthalmol Vis Sci. 2014;56(1):372-81.
Menghini, M., Lujan, B. J., Zayit-Soudry, S., Syed, R., Porco, T. C., Bayabo, K., Carroll, J., Roorda, A., & Duncan, J. L. (2014). Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects. Investigative Ophthalmology & Visual Science, 56(1), 372-81. https://doi.org/10.1167/iovs.14-15521
Menghini M, et al. Correlation of Outer Nuclear Layer Thickness With Cone Density Values in Patients With Retinitis Pigmentosa and Healthy Subjects. Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):372-81. PubMed PMID: 25515570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects. AU - Menghini,Moreno, AU - Lujan,Brandon J, AU - Zayit-Soudry,Shiri, AU - Syed,Reema, AU - Porco,Travis C, AU - Bayabo,Kristine, AU - Carroll,Joseph, AU - Roorda,Austin, AU - Duncan,Jacque L, Y1 - 2014/12/16/ PY - 2014/12/18/entrez PY - 2014/12/18/pubmed PY - 2015/3/4/medline KW - adaptive optics scanning laser ophthalmoscopy KW - cone density KW - optical coherence tomography KW - outer nuclear layer thickness KW - retinitis pigmentosa SP - 372 EP - 81 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 56 IS - 1 N2 - PURPOSE: We studied the correlation between outer nuclear layer (ONL) thickness and cone density in normal eyes and eyes with retinitis pigmentosa (RP). METHODS: Spectral-domain optical coherence tomography (SD-OCT) scans were acquired using a displaced pupil entry position of the scanning beam to distinguish Henle's fiber layer from the ONL in 20 normal eyes (10 subjects) and 12 eyes with RP (7 patients). Cone photoreceptors were imaged using adaptive optics scanning laser ophthalmoscopy. The ONL thickness and cone density were measured at 0.5° intervals along the horizontal meridian through the fovea nasally and temporally. The ONL thickness and cone density were correlated using Spearman's rank correlation coefficient r. RESULTS: Cone densities averaged over the central 6° were lower in eyes with RP than normal, but showed high variability in both groups. The ONL thickness and cone density were significantly correlated when all retinal eccentricities were combined (r = 0.74); the correlation for regions within 0.5° to 1.5° eccentricity was stronger (r = 0.67) than between 1.5° and 3.0° eccentricity (r = 0.23). Although cone densities were lower between 0.5° and 1.5° in eyes with RP, ONL thickness measures at identical retinal locations were similar in the two groups (P = 0.31), and interindividual variation was high for ONL and cone density measures. Although ONL thickness and retinal eccentricity were important predictors of cone density, eccentricity was over 3 times more important. CONCLUSIONS: The ONL thickness and cone density were correlated in normal eyes and eyes with RP, but both were strongly correlated with retinal eccentricity, precluding estimation of cone density from ONL thickness. (ClinicalTrials.gov number, NCT00254605.). SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/25515570/Correlation_of_outer_nuclear_layer_thickness_with_cone_density_values_in_patients_with_retinitis_pigmentosa_and_healthy_subjects_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-15521 DB - PRIME DP - Unbound Medicine ER -