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Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.
J Crohns Colitis. 2015 Jan; 9(1):86-106.JC

Abstract

OBJECTIVE

We performed a systematic review for Complementary and Alternative Medicine [CAM] as defined by the National Institute of Health in Inflammatory Bowel Disease [IBD], ie Crohn's disease [CD] and ulcerative colitis [UC], with the exception of dietary and nutritional supplements, and manipulative therapies.

METHODS

A computerized search of databases [Cochrane Library, Pubmed/Medline, PsychINFO, and Scopus] through March 2014 was performed. We screened the reference sections of original studies and systematic reviews in English language for CAM in IBD, CD and UC. Randomized controlled trials [RCT] and controlled trials [CT] were referred and assessed using the Cochrane risk of bias tool.

RESULTS

A total of: 26 RCT and 3 CT for herbal medicine, eg aloe-vera gel, andrographis paniculata, artemisia absinthium, barley foodstuff, boswellia serrata, cannabis, curcumin, evening primrose oil, Myrrhinil intest®, plantago ovata, silymarin, sophora, tormentil, wheatgrass-juice and wormwood; 1 RCT for trichuris suis ovata; 7 RCT for mind/body interventions such as lifestyle modification, hypnotherapy, relaxation training and mindfulness; and 2 RCT in acupuncture; were found. Risk of bias was quite heterogeneous. Best evidence was found for herbal therapy, ie plantago ovata and curcumin in UC maintenance therapy, wormwood in CD, mind/body therapy and self-intervention in UC, and acupuncture in UC and CD.

CONCLUSIONS

Complementary and alternative therapies might be effective for the treatment of inflammatory bowel diseases; however, given the low number of trials and the heterogeneous methodological quality of trials, further in-depth research is necessary.

Authors+Show Affiliations

Department of Integrative Gastroenterology, Faculty of Medicine, University of Duisburg-Essen, Germany Department of Internal and Integrative Medicine, Faculty of Medicine, University of Duisburg-Essen, Germany jost.langhorst@gmx.de.Department of Internal and Integrative Medicine, Faculty of Medicine, University of Duisburg-Essen, Germany.Department of Internal and Integrative Medicine, Faculty of Medicine, University of Duisburg-Essen, Germany Australian Research Centre in Complementary and Integrative Medicine[], Faculty of Health, University of Technology Sydney, Australia.Department of Internal and Integrative Medicine, Faculty of Medicine, University of Duisburg-Essen, Germany.Department of Internal and Integrative Medicine, Faculty of Medicine, University of Duisburg-Essen, Germany Australian Research Centre in Complementary and Integrative Medicine[], Faculty of Health, University of Technology Sydney, Australia.Department of Internal and Integrative Medicine, Faculty of Medicine, University of Duisburg-Essen, Germany.Department of Inflammatory Bowel Disease, Harvard Medical School, Boston, MA, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25518050

Citation

Langhorst, J, et al. "Systematic Review of Complementary and Alternative Medicine Treatments in Inflammatory Bowel Diseases." Journal of Crohn's & Colitis, vol. 9, no. 1, 2015, pp. 86-106.
Langhorst J, Wulfert H, Lauche R, et al. Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases. J Crohns Colitis. 2015;9(1):86-106.
Langhorst, J., Wulfert, H., Lauche, R., Klose, P., Cramer, H., Dobos, G. J., & Korzenik, J. (2015). Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases. Journal of Crohn's & Colitis, 9(1), 86-106. https://doi.org/10.1093/ecco-jcc/jju007
Langhorst J, et al. Systematic Review of Complementary and Alternative Medicine Treatments in Inflammatory Bowel Diseases. J Crohns Colitis. 2015;9(1):86-106. PubMed PMID: 25518050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases. AU - Langhorst,J, AU - Wulfert,H, AU - Lauche,R, AU - Klose,P, AU - Cramer,H, AU - Dobos,G J, AU - Korzenik,J, Y1 - 2014/11/28/ PY - 2014/12/18/entrez PY - 2014/12/18/pubmed PY - 2015/10/16/medline KW - CAM KW - Crohn’s disease KW - Ulcerative colitis KW - complementary and alternative medicine KW - review SP - 86 EP - 106 JF - Journal of Crohn's & colitis JO - J Crohns Colitis VL - 9 IS - 1 N2 - OBJECTIVE: We performed a systematic review for Complementary and Alternative Medicine [CAM] as defined by the National Institute of Health in Inflammatory Bowel Disease [IBD], ie Crohn's disease [CD] and ulcerative colitis [UC], with the exception of dietary and nutritional supplements, and manipulative therapies. METHODS: A computerized search of databases [Cochrane Library, Pubmed/Medline, PsychINFO, and Scopus] through March 2014 was performed. We screened the reference sections of original studies and systematic reviews in English language for CAM in IBD, CD and UC. Randomized controlled trials [RCT] and controlled trials [CT] were referred and assessed using the Cochrane risk of bias tool. RESULTS: A total of: 26 RCT and 3 CT for herbal medicine, eg aloe-vera gel, andrographis paniculata, artemisia absinthium, barley foodstuff, boswellia serrata, cannabis, curcumin, evening primrose oil, Myrrhinil intest®, plantago ovata, silymarin, sophora, tormentil, wheatgrass-juice and wormwood; 1 RCT for trichuris suis ovata; 7 RCT for mind/body interventions such as lifestyle modification, hypnotherapy, relaxation training and mindfulness; and 2 RCT in acupuncture; were found. Risk of bias was quite heterogeneous. Best evidence was found for herbal therapy, ie plantago ovata and curcumin in UC maintenance therapy, wormwood in CD, mind/body therapy and self-intervention in UC, and acupuncture in UC and CD. CONCLUSIONS: Complementary and alternative therapies might be effective for the treatment of inflammatory bowel diseases; however, given the low number of trials and the heterogeneous methodological quality of trials, further in-depth research is necessary. SN - 1876-4479 UR - https://www.unboundmedicine.com/medline/citation/25518050/Systematic_review_of_complementary_and_alternative_medicine_treatments_in_inflammatory_bowel_diseases_ L2 - https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1093/ecco-jcc/jju007 DB - PRIME DP - Unbound Medicine ER -