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Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis.
Food Funct 2015; 6(2):558-65FF

Abstract

In this study, two Lactobacillus strains (L. rhamnosus LA68 and L. plantarum WCFS1) were evaluated for their effects on high fat diet induced pathology in mice. The aim was to determine whether the administration of lactic acid bacteria had beneficial effects on ameliorating pathology. C57BL/6 mice fed a high fat diet were orally administered with the Lactobacillus strains. Both the metabolic and immunological parameters were analyzed. The administration of both of the strains had beneficial effects on mouse weight, serum cholesterol, TNF-α levels and liver histology. LA68 lowered the total cholesterol and HDL levels more prominently, whereas WCFS1 was more potent in lowering the TG and LDL levels. Leptin and adiponectin levels were increased in all experimental groups to different extents. The administration of L. plantarum WCFS1 led to a marked increase in leptin levels, as well as an increase in CD3+CD4+ and CD3+CD8+ cells, and a decrease of CD25+ cells, and had a lowering effect on IL-6 production and cell metabolic activity. In conclusion, active administration of both Lactobacillus strains had a positive effect on HFD-induced pathology. Although both of the tested strains had beneficial effects, oral administration of WCFS1 increased leptin levels and had a more prominent immunomodulatory effect, which should be taken into consideration in case of humane usage.

Authors+Show Affiliations

Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. nevenam@pharmacy.bg.ac.rs.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25518825

Citation

Ivanovic, Nevena, et al. "Lactobacillus Rhamnosus LA68 and Lactobacillus Plantarum WCFS1 Differently Influence Metabolic and Immunological Parameters in High Fat Diet-induced Hypercholesterolemia and Hepatic Steatosis." Food & Function, vol. 6, no. 2, 2015, pp. 558-65.
Ivanovic N, Minic R, Dimitrijevic L, et al. Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. Food Funct. 2015;6(2):558-65.
Ivanovic, N., Minic, R., Dimitrijevic, L., Radojevic Skodric, S., Zivkovic, I., & Djordjevic, B. (2015). Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. Food & Function, 6(2), pp. 558-65. doi:10.1039/c4fo00843j.
Ivanovic N, et al. Lactobacillus Rhamnosus LA68 and Lactobacillus Plantarum WCFS1 Differently Influence Metabolic and Immunological Parameters in High Fat Diet-induced Hypercholesterolemia and Hepatic Steatosis. Food Funct. 2015;6(2):558-65. PubMed PMID: 25518825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. AU - Ivanovic,Nevena, AU - Minic,Rajna, AU - Dimitrijevic,Ljiljana, AU - Radojevic Skodric,Sanja, AU - Zivkovic,Irena, AU - Djordjevic,Brizita, PY - 2014/12/19/entrez PY - 2014/12/19/pubmed PY - 2016/3/2/medline SP - 558 EP - 65 JF - Food & function JO - Food Funct VL - 6 IS - 2 N2 - In this study, two Lactobacillus strains (L. rhamnosus LA68 and L. plantarum WCFS1) were evaluated for their effects on high fat diet induced pathology in mice. The aim was to determine whether the administration of lactic acid bacteria had beneficial effects on ameliorating pathology. C57BL/6 mice fed a high fat diet were orally administered with the Lactobacillus strains. Both the metabolic and immunological parameters were analyzed. The administration of both of the strains had beneficial effects on mouse weight, serum cholesterol, TNF-α levels and liver histology. LA68 lowered the total cholesterol and HDL levels more prominently, whereas WCFS1 was more potent in lowering the TG and LDL levels. Leptin and adiponectin levels were increased in all experimental groups to different extents. The administration of L. plantarum WCFS1 led to a marked increase in leptin levels, as well as an increase in CD3+CD4+ and CD3+CD8+ cells, and a decrease of CD25+ cells, and had a lowering effect on IL-6 production and cell metabolic activity. In conclusion, active administration of both Lactobacillus strains had a positive effect on HFD-induced pathology. Although both of the tested strains had beneficial effects, oral administration of WCFS1 increased leptin levels and had a more prominent immunomodulatory effect, which should be taken into consideration in case of humane usage. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/25518825/Lactobacillus_rhamnosus_LA68_and_Lactobacillus_plantarum_WCFS1_differently_influence_metabolic_and_immunological_parameters_in_high_fat_diet_induced_hypercholesterolemia_and_hepatic_steatosis_ L2 - https://doi.org/10.1039/c4fo00843j DB - PRIME DP - Unbound Medicine ER -