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Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis.

Abstract

In this study, two Lactobacillus strains (L. rhamnosus LA68 and L. plantarum WCFS1) were evaluated for their effects on high fat diet induced pathology in mice. The aim was to determine whether the administration of lactic acid bacteria had beneficial effects on ameliorating pathology. C57BL/6 mice fed a high fat diet were orally administered with the Lactobacillus strains. Both the metabolic and immunological parameters were analyzed. The administration of both of the strains had beneficial effects on mouse weight, serum cholesterol, TNF-α levels and liver histology. LA68 lowered the total cholesterol and HDL levels more prominently, whereas WCFS1 was more potent in lowering the TG and LDL levels. Leptin and adiponectin levels were increased in all experimental groups to different extents. The administration of L. plantarum WCFS1 led to a marked increase in leptin levels, as well as an increase in CD3+CD4+ and CD3+CD8+ cells, and a decrease of CD25+ cells, and had a lowering effect on IL-6 production and cell metabolic activity. In conclusion, active administration of both Lactobacillus strains had a positive effect on HFD-induced pathology. Although both of the tested strains had beneficial effects, oral administration of WCFS1 increased leptin levels and had a more prominent immunomodulatory effect, which should be taken into consideration in case of humane usage.

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  • Authors+Show Affiliations

    ,

    Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. nevenam@pharmacy.bg.ac.rs.

    , , , ,

    Source

    Food & function 6:2 2015 Feb pg 558-65

    MeSH

    Adiponectin
    Animals
    Aspartate Aminotransferases
    Body Weight
    CD13 Antigens
    Cholesterol, HDL
    Cholesterol, LDL
    Diet, High-Fat
    Fatty Liver
    Hypercholesterolemia
    Interleukin-6
    Lactobacillus plantarum
    Lactobacillus rhamnosus
    Leptin
    Liver
    Male
    Mice
    Mice, Inbred C57BL
    Obesity
    Probiotics
    Triglycerides
    Tumor Necrosis Factor-alpha

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25518825

    Citation

    Ivanovic, Nevena, et al. "Lactobacillus Rhamnosus LA68 and Lactobacillus Plantarum WCFS1 Differently Influence Metabolic and Immunological Parameters in High Fat Diet-induced Hypercholesterolemia and Hepatic Steatosis." Food & Function, vol. 6, no. 2, 2015, pp. 558-65.
    Ivanovic N, Minic R, Dimitrijevic L, et al. Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. Food Funct. 2015;6(2):558-65.
    Ivanovic, N., Minic, R., Dimitrijevic, L., Radojevic Skodric, S., Zivkovic, I., & Djordjevic, B. (2015). Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. Food & Function, 6(2), pp. 558-65. doi:10.1039/c4fo00843j.
    Ivanovic N, et al. Lactobacillus Rhamnosus LA68 and Lactobacillus Plantarum WCFS1 Differently Influence Metabolic and Immunological Parameters in High Fat Diet-induced Hypercholesterolemia and Hepatic Steatosis. Food Funct. 2015;6(2):558-65. PubMed PMID: 25518825.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. AU - Ivanovic,Nevena, AU - Minic,Rajna, AU - Dimitrijevic,Ljiljana, AU - Radojevic Skodric,Sanja, AU - Zivkovic,Irena, AU - Djordjevic,Brizita, PY - 2014/12/19/entrez PY - 2014/12/19/pubmed PY - 2016/3/2/medline SP - 558 EP - 65 JF - Food & function JO - Food Funct VL - 6 IS - 2 N2 - In this study, two Lactobacillus strains (L. rhamnosus LA68 and L. plantarum WCFS1) were evaluated for their effects on high fat diet induced pathology in mice. The aim was to determine whether the administration of lactic acid bacteria had beneficial effects on ameliorating pathology. C57BL/6 mice fed a high fat diet were orally administered with the Lactobacillus strains. Both the metabolic and immunological parameters were analyzed. The administration of both of the strains had beneficial effects on mouse weight, serum cholesterol, TNF-α levels and liver histology. LA68 lowered the total cholesterol and HDL levels more prominently, whereas WCFS1 was more potent in lowering the TG and LDL levels. Leptin and adiponectin levels were increased in all experimental groups to different extents. The administration of L. plantarum WCFS1 led to a marked increase in leptin levels, as well as an increase in CD3+CD4+ and CD3+CD8+ cells, and a decrease of CD25+ cells, and had a lowering effect on IL-6 production and cell metabolic activity. In conclusion, active administration of both Lactobacillus strains had a positive effect on HFD-induced pathology. Although both of the tested strains had beneficial effects, oral administration of WCFS1 increased leptin levels and had a more prominent immunomodulatory effect, which should be taken into consideration in case of humane usage. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/25518825/Lactobacillus_rhamnosus_LA68_and_Lactobacillus_plantarum_WCFS1_differently_influence_metabolic_and_immunological_parameters_in_high_fat_diet_induced_hypercholesterolemia_and_hepatic_steatosis_ L2 - https://doi.org/10.1039/c4fo00843j DB - PRIME DP - Unbound Medicine ER -