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Premenstrual syndrome is associated with blunted cortisol reactivity to the TSST.
Stress 2015; 18(2):160-8S

Abstract

This study assessed the effects of premenstrual syndrome (PMS) and menstrual phases on the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system axis and psychological responses to the Trier Social Stress Test (TSST). Thirty-six PMS women (mean age 21.69 ± 2.16 years) and 36 control women (mean age 22.03 ± 2.48 years) participated in the TSST task, either in the follicular phase or in the late luteal phase (each group N = 18). Saliva samples, heart rate and subjective stress levels were collected for seven time points throughout the test (10, 20, 30, 40, 55, 70 and 100 min). The results indicated that in comparison with control women, PMS women displayed blunted cortisol stress responses to the TSST irrespective of the menstrual phases, as indexed by the cortisol levels across time, area under the curve with respect to ground (AUCg) and peak change scores of cortisol. The results also demonstrated that the measurements indexed by cortisol levels across time, AUCg and peak change scores of heart rate were smaller in women tested during the late luteal phase than during the follicular phase. Correlation results indicated that AUCg was negatively correlated with PMS scores. These results suggest that measures of cortisol, rather than heart rate or subjective responses to stress, may be most closely associated with PMS. Furthermore, hypo-reactivity of the HPA axis may be pathologically relevant to PMS because it predicts heightened PMS severity.

Authors+Show Affiliations

Beijing Key Laboratory of Applied Experimental Psychology, School of Psychology, Beijing Normal University , Beijing , China .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25518868

Citation

Huang, Yamei, et al. "Premenstrual Syndrome Is Associated With Blunted Cortisol Reactivity to the TSST." Stress (Amsterdam, Netherlands), vol. 18, no. 2, 2015, pp. 160-8.
Huang Y, Zhou R, Wu M, et al. Premenstrual syndrome is associated with blunted cortisol reactivity to the TSST. Stress. 2015;18(2):160-8.
Huang, Y., Zhou, R., Wu, M., Wang, Q., & Zhao, Y. (2015). Premenstrual syndrome is associated with blunted cortisol reactivity to the TSST. Stress (Amsterdam, Netherlands), 18(2), pp. 160-8. doi:10.3109/10253890.2014.999234.
Huang Y, et al. Premenstrual Syndrome Is Associated With Blunted Cortisol Reactivity to the TSST. Stress. 2015;18(2):160-8. PubMed PMID: 25518868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Premenstrual syndrome is associated with blunted cortisol reactivity to the TSST. AU - Huang,Yamei, AU - Zhou,Renlai, AU - Wu,Mengying, AU - Wang,Qingguo, AU - Zhao,Yan, Y1 - 2015/01/23/ PY - 2014/12/19/entrez PY - 2014/12/19/pubmed PY - 2016/7/14/medline KW - Heart rate KW - TSST KW - menstrual cycle KW - premenstrual syndrome KW - salivary cortisol KW - stress response SP - 160 EP - 8 JF - Stress (Amsterdam, Netherlands) JO - Stress VL - 18 IS - 2 N2 - This study assessed the effects of premenstrual syndrome (PMS) and menstrual phases on the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system axis and psychological responses to the Trier Social Stress Test (TSST). Thirty-six PMS women (mean age 21.69 ± 2.16 years) and 36 control women (mean age 22.03 ± 2.48 years) participated in the TSST task, either in the follicular phase or in the late luteal phase (each group N = 18). Saliva samples, heart rate and subjective stress levels were collected for seven time points throughout the test (10, 20, 30, 40, 55, 70 and 100 min). The results indicated that in comparison with control women, PMS women displayed blunted cortisol stress responses to the TSST irrespective of the menstrual phases, as indexed by the cortisol levels across time, area under the curve with respect to ground (AUCg) and peak change scores of cortisol. The results also demonstrated that the measurements indexed by cortisol levels across time, AUCg and peak change scores of heart rate were smaller in women tested during the late luteal phase than during the follicular phase. Correlation results indicated that AUCg was negatively correlated with PMS scores. These results suggest that measures of cortisol, rather than heart rate or subjective responses to stress, may be most closely associated with PMS. Furthermore, hypo-reactivity of the HPA axis may be pathologically relevant to PMS because it predicts heightened PMS severity. SN - 1607-8888 UR - https://www.unboundmedicine.com/medline/citation/25518868/Premenstrual_syndrome_is_associated_with_blunted_cortisol_reactivity_to_the_TSST_ L2 - http://www.tandfonline.com/doi/full/10.3109/10253890.2014.999234 DB - PRIME DP - Unbound Medicine ER -