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Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation.
AAPS PharmSciTech. 2015 Jun; 16(3):716-29.AP

Abstract

In the present work, an attempt has been made to screen Prosopis africana seed gum (PG), anionic polymer for extended release tablet formulation. Different categories of drugs (charge basis) like diclofenac sodium (DS), chlorpheniramine maleate (CPM), and ibuprofen (IB) were compacted with PG and compared with different polymers (charge basis) like xanthan gum (XG), hydroxypropyl methyl cellulose (HPMC-K100M), and chitosan (CP). For each drug, 12 batches of tablets were prepared by wet granulation technique, and granules were evaluated for flow properties, compressibility, and compactibility by Heckel and Leuenberger analysis, swelling index, in vitro dissolution studies, etc. It has been observed that granules of all batches showed acceptable flowability. According to Heckel and Leuenberger analysis, granules of PG-containing compacts showed similar and satisfactory compressibility and compactibility compared to granules of other polymers. PG showed significant swelling (P < 0.05) compared to HPMC, and better than CP and XG. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) study showed no interaction between drugs and polymers. From all PG-containing compacts of aforesaid drugs, drug release was sustained for 12 h following anomalous transport. Especially, polyelectrolyte complex formation retarded the release of oppositely charged drug (CPM-PG). However, extended release was noted in both anionic (DS) and nonionic (IB) drugs, maybe due to swollen gel. All compacts were found to be stable for 3-month period during stability study. This concludes that swelling and release retardation of PG has close resemblance to HPMC, so it can be used as extended release polymer for all types of drugs.

Authors+Show Affiliations

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra State, 416013, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25523143

Citation

Nadaf, Sameer, et al. "Evaluation of Prosopis Africana Seed Gum as an Extended Release Polymer for Tablet Formulation." AAPS PharmSciTech, vol. 16, no. 3, 2015, pp. 716-29.
Nadaf S, Nnamani P, Jadhav N. Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation. AAPS PharmSciTech. 2015;16(3):716-29.
Nadaf, S., Nnamani, P., & Jadhav, N. (2015). Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation. AAPS PharmSciTech, 16(3), 716-29. https://doi.org/10.1208/s12249-014-0256-y
Nadaf S, Nnamani P, Jadhav N. Evaluation of Prosopis Africana Seed Gum as an Extended Release Polymer for Tablet Formulation. AAPS PharmSciTech. 2015;16(3):716-29. PubMed PMID: 25523143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation. AU - Nadaf,Sameer, AU - Nnamani,Petra, AU - Jadhav,Namdeo, Y1 - 2014/12/19/ PY - 2014/04/23/received PY - 2014/11/25/accepted PY - 2014/12/20/entrez PY - 2014/12/20/pubmed PY - 2016/2/18/medline SP - 716 EP - 29 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 16 IS - 3 N2 - In the present work, an attempt has been made to screen Prosopis africana seed gum (PG), anionic polymer for extended release tablet formulation. Different categories of drugs (charge basis) like diclofenac sodium (DS), chlorpheniramine maleate (CPM), and ibuprofen (IB) were compacted with PG and compared with different polymers (charge basis) like xanthan gum (XG), hydroxypropyl methyl cellulose (HPMC-K100M), and chitosan (CP). For each drug, 12 batches of tablets were prepared by wet granulation technique, and granules were evaluated for flow properties, compressibility, and compactibility by Heckel and Leuenberger analysis, swelling index, in vitro dissolution studies, etc. It has been observed that granules of all batches showed acceptable flowability. According to Heckel and Leuenberger analysis, granules of PG-containing compacts showed similar and satisfactory compressibility and compactibility compared to granules of other polymers. PG showed significant swelling (P < 0.05) compared to HPMC, and better than CP and XG. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) study showed no interaction between drugs and polymers. From all PG-containing compacts of aforesaid drugs, drug release was sustained for 12 h following anomalous transport. Especially, polyelectrolyte complex formation retarded the release of oppositely charged drug (CPM-PG). However, extended release was noted in both anionic (DS) and nonionic (IB) drugs, maybe due to swollen gel. All compacts were found to be stable for 3-month period during stability study. This concludes that swelling and release retardation of PG has close resemblance to HPMC, so it can be used as extended release polymer for all types of drugs. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/25523143/Evaluation_of_Prosopis_africana_Seed_Gum_as_an_Extended_Release_Polymer_for_Tablet_Formulation_ DB - PRIME DP - Unbound Medicine ER -