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Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study.

Abstract

BACKGROUND

There is a growing focus on nutritional therapy for Alzheimer's disease (AD), and controversy exists regarding the association between AD and homocysteine (Hcy), vitamin B12, and folate levels.

OBJECTIVE

The present study evaluated the association between AD and the combined levels of Hcy, vitamin B12, and folate.

METHODS

This case-control study consisted of 115 patients with AD and 115 matched controls. Serum folate and vitamin B12 were measured using an automated immunoassay analyzer. Plasma Hcy was measured using high-performance liquid chromatography. The association between AD and Hcy, vitamin B12, and folate was analyzed using binary logistic regression, adjusted for age and sex.

RESULTS

With the combination of normal blood Hcy, vitamin B12, and folate levels as the reference category, low vitamin B12 in subjects with normal Hcy and folate was associated with AD (adjusted odds ratio [OR], 4.6; 95% confidence interval [CI]: 1.6-13.2). The combination of low vitamin B12 and folate in subjects with normal Hcy was associated with AD (adjusted OR, 4.3; 95% CI: 1.3-14.6). The combination of high Hcy and low folate levels in patients with normal vitamin B12 was associated with AD (adjusted OR, 17.0; 95% CI: 5.4- 53.4). The combination of high Hcy, low vitamin B12, and any folate level was associated with AD (adjusted OR, 30.5; 95% CI: 9.7-95.9).

CONCLUSION

Vitamin B12 was directly associated with AD. The combination of high Hcy, low vitamin B12, and any folate level represented the poorest association with AD.

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  • Authors+Show Affiliations

    , , , , , , , , ,

    Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China. huangguowei@tmu.edu.cn.

    Source

    Current Alzheimer research 12:1 2015 pg 88-94

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Case-Control Studies
    Chromatography, High Pressure Liquid
    Cognition Disorders
    Confidence Intervals
    Female
    Folic Acid
    Homocysteine
    Humans
    Male
    Middle Aged
    Odds Ratio
    Psychiatric Status Rating Scales
    Retrospective Studies
    Surveys and Questionnaires
    Vitamin B 12

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25523421

    Citation

    Chen, Hui, et al. "Associations Between Alzheimer's Disease and Blood Homocysteine, Vitamin B12, and Folate: a Case-control Study." Current Alzheimer Research, vol. 12, no. 1, 2015, pp. 88-94.
    Chen H, Liu S, Ji L, et al. Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study. Curr Alzheimer Res. 2015;12(1):88-94.
    Chen, H., Liu, S., Ji, L., Wu, T., Ma, F., Ji, Y., ... Huang, G. (2015). Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study. Current Alzheimer Research, 12(1), pp. 88-94.
    Chen H, et al. Associations Between Alzheimer's Disease and Blood Homocysteine, Vitamin B12, and Folate: a Case-control Study. Curr Alzheimer Res. 2015;12(1):88-94. PubMed PMID: 25523421.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study. AU - Chen,Hui, AU - Liu,Shuai, AU - Ji,Lu, AU - Wu,Tianfeng, AU - Ma,Fei, AU - Ji,Yong, AU - Zhou,Yuying, AU - Zheng,Miaoyan, AU - Zhang,Meilin, AU - Huang,Guowei, PY - 2014/08/22/received PY - 2014/11/21/revised PY - 2014/12/04/accepted PY - 2014/12/20/entrez PY - 2014/12/20/pubmed PY - 2015/9/1/medline SP - 88 EP - 94 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 12 IS - 1 N2 - BACKGROUND: There is a growing focus on nutritional therapy for Alzheimer's disease (AD), and controversy exists regarding the association between AD and homocysteine (Hcy), vitamin B12, and folate levels. OBJECTIVE: The present study evaluated the association between AD and the combined levels of Hcy, vitamin B12, and folate. METHODS: This case-control study consisted of 115 patients with AD and 115 matched controls. Serum folate and vitamin B12 were measured using an automated immunoassay analyzer. Plasma Hcy was measured using high-performance liquid chromatography. The association between AD and Hcy, vitamin B12, and folate was analyzed using binary logistic regression, adjusted for age and sex. RESULTS: With the combination of normal blood Hcy, vitamin B12, and folate levels as the reference category, low vitamin B12 in subjects with normal Hcy and folate was associated with AD (adjusted odds ratio [OR], 4.6; 95% confidence interval [CI]: 1.6-13.2). The combination of low vitamin B12 and folate in subjects with normal Hcy was associated with AD (adjusted OR, 4.3; 95% CI: 1.3-14.6). The combination of high Hcy and low folate levels in patients with normal vitamin B12 was associated with AD (adjusted OR, 17.0; 95% CI: 5.4- 53.4). The combination of high Hcy, low vitamin B12, and any folate level was associated with AD (adjusted OR, 30.5; 95% CI: 9.7-95.9). CONCLUSION: Vitamin B12 was directly associated with AD. The combination of high Hcy, low vitamin B12, and any folate level represented the poorest association with AD. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/25523421/Associations_between_Alzheimer's_disease_and_blood_homocysteine_vitamin_B12_and_folate:_a_case_control_study_ L2 - http://www.eurekaselect.com/127052/article DB - PRIME DP - Unbound Medicine ER -