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Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency.
Eur J Nutr. 2016 Feb; 55(1):55-61.EJ

Abstract

PURPOSE

Selenium is an essential trace mineral and a component of selenoproteins that are involved in the production of thyroid hormones and in regulating the immune response. We aimed to explore the effect of low-dose selenium supplementation on thyroid peroxidase antibody (TPO-Ab) concentration and thyroid function in pregnant women from a mild-to-moderate iodine-deficient population.

METHODS

Samples and data were from a secondary analysis of Selenium in PRegnancy INTervention (SPRINT), a double-blind, randomized, placebo-controlled study that recruited 230 women with singleton pregnancies from a UK antenatal clinic at 12 weeks of gestation. Women were randomized to receive 60 µg/day selenium or placebo until delivery. Serum thyroid peroxidase antibodies (TPO-Ab), thyrotropin (TSH) and free thyroxine (FT4) were measured at 12, 20 and 35 weeks and thyroglobulin antibodies (Tg-Ab) at 12 weeks.

RESULTS

93.5% of participants completed the study. Se supplementation had no more effect than placebo in decreasing TPO-Ab concentration or the prevalence of TPO-Ab positivity during the course of pregnancy. In women who were either TPO-Ab or Tg-Ab negative at baseline (Thy-Ab(-ve)), TSH increased and FT4 decreased significantly throughout gestation (P < 0.001), with no difference between treatment groups. In women who were Thy-Ab(+ve) at baseline, TSH tended to decrease and was lower than placebo at 35 weeks (P = 0.050). FT4 fell more on Se than placebo supplementation and was significantly lower at 35 weeks (P = 0.029).

CONCLUSIONS

Low-dose selenium supplementation in pregnant women with mild-to-moderate deficiency had no effect on TPO-Ab concentration, but tended to change thyroid function in Thy-Ab(+ve) women.

Authors+Show Affiliations

Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK. Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, China.Department of Clinical Health Psychology, Tilburg University, Tilburg, The Netherlands.Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.Clinical Laboratories, Máxima Medical Center Eindhoven, Veldhoven, The Netherlands.Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, UK.Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK. m.rayman@surrey.ac.uk.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25524327

Citation

Mao, Jinyuan, et al. "Effect of Low-dose Selenium On Thyroid Autoimmunity and Thyroid Function in UK Pregnant Women With Mild-to-moderate Iodine Deficiency." European Journal of Nutrition, vol. 55, no. 1, 2016, pp. 55-61.
Mao J, Pop VJ, Bath SC, et al. Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency. Eur J Nutr. 2016;55(1):55-61.
Mao, J., Pop, V. J., Bath, S. C., Vader, H. L., Redman, C. W., & Rayman, M. P. (2016). Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency. European Journal of Nutrition, 55(1), 55-61. https://doi.org/10.1007/s00394-014-0822-9
Mao J, et al. Effect of Low-dose Selenium On Thyroid Autoimmunity and Thyroid Function in UK Pregnant Women With Mild-to-moderate Iodine Deficiency. Eur J Nutr. 2016;55(1):55-61. PubMed PMID: 25524327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency. AU - Mao,Jinyuan, AU - Pop,Victor J, AU - Bath,Sarah C, AU - Vader,Huib L, AU - Redman,Christopher W G, AU - Rayman,Margaret P, Y1 - 2014/12/19/ PY - 2014/10/28/received PY - 2014/12/10/accepted PY - 2014/12/20/entrez PY - 2014/12/20/pubmed PY - 2016/11/9/medline KW - Iodine KW - Pregnancy KW - Selenium KW - Thyroid autoimmunity KW - Thyroid function KW - Thyroid peroxidase antibodies SP - 55 EP - 61 JF - European journal of nutrition JO - Eur J Nutr VL - 55 IS - 1 N2 - PURPOSE: Selenium is an essential trace mineral and a component of selenoproteins that are involved in the production of thyroid hormones and in regulating the immune response. We aimed to explore the effect of low-dose selenium supplementation on thyroid peroxidase antibody (TPO-Ab) concentration and thyroid function in pregnant women from a mild-to-moderate iodine-deficient population. METHODS: Samples and data were from a secondary analysis of Selenium in PRegnancy INTervention (SPRINT), a double-blind, randomized, placebo-controlled study that recruited 230 women with singleton pregnancies from a UK antenatal clinic at 12 weeks of gestation. Women were randomized to receive 60 µg/day selenium or placebo until delivery. Serum thyroid peroxidase antibodies (TPO-Ab), thyrotropin (TSH) and free thyroxine (FT4) were measured at 12, 20 and 35 weeks and thyroglobulin antibodies (Tg-Ab) at 12 weeks. RESULTS: 93.5% of participants completed the study. Se supplementation had no more effect than placebo in decreasing TPO-Ab concentration or the prevalence of TPO-Ab positivity during the course of pregnancy. In women who were either TPO-Ab or Tg-Ab negative at baseline (Thy-Ab(-ve)), TSH increased and FT4 decreased significantly throughout gestation (P < 0.001), with no difference between treatment groups. In women who were Thy-Ab(+ve) at baseline, TSH tended to decrease and was lower than placebo at 35 weeks (P = 0.050). FT4 fell more on Se than placebo supplementation and was significantly lower at 35 weeks (P = 0.029). CONCLUSIONS: Low-dose selenium supplementation in pregnant women with mild-to-moderate deficiency had no effect on TPO-Ab concentration, but tended to change thyroid function in Thy-Ab(+ve) women. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/25524327/Effect_of_low_dose_selenium_on_thyroid_autoimmunity_and_thyroid_function_in_UK_pregnant_women_with_mild_to_moderate_iodine_deficiency_ L2 - https://dx.doi.org/10.1007/s00394-014-0822-9 DB - PRIME DP - Unbound Medicine ER -