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Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia.
J Vet Diagn Invest. 2015 Jan; 27(1):31-40.JV

Abstract

Chinese Shar-Pei dogs have a high prevalence of hypocobalaminemia and are commonly presented with clinical signs suggestive of severe and long-standing gastrointestinal disease such as diarrhea, vomiting, and/or weight loss. The aim of the current study was to evaluate serum concentrations of inflammatory markers, markers for intestinal disease, and immunological markers in Shar-Peis with hypocobalaminemia or normocobalaminemia (serum cobalamin concentrations within the reference interval). Serum samples from Shar-Peis were collected from various parts of the United States. Serum concentrations of inflammatory markers (i.e., C-reactive protein [CRP], calprotectin [CP], and S100A12), hyaluronic acid (HA, a marker for cutaneous mucinosis), and analytes commonly altered in chronic intestinal diseases (i.e., albumin, zinc, alpha1-proteinease inhibitor [α1PI], immunoglobulin [Ig]A, and IgM) were compared between Shar-Peis with hypocobalaminemia and Shar-Peis with normocobalaminemia. Serum concentrations of CRP, CP, S100A12, HA, zinc, and cα1-PI concentrations did not differ between hypocobalaminemic and normocobalaminemic Shar-Peis (P > 0.05). Serum concentrations of albumin were significantly lower in hypocobalaminemic Shar-Peis (median: 2.5 g/dl) than in normocobalaminemic Shar-Peis (median: 2.9 g/dl; P < 0.0001). Higher serum IgA concentrations and lower serum IgM concentrations were observed in hypocobalaminemic Shar-Peis (median: 1.7 g/l and 0.8 g/l, respectively) than in normocobalaminemic Shar-Peis (median: 0.7 g/l and 1.9 g/l, respectively; both P < 0.0001). In conclusion, no difference was found in serum concentrations of CRP, CP, S100A12, and HA between hypocobalaminemic and normocobalaminemic Shar-Peis whereas some differences were observed in analytes (e.g., albumin, IgA, and IgM) that may be altered in patients with chronic enteropathies.

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Authors+Show Affiliations

Grützner N
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Grützner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TXMicroscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX tierarztbz@hotmail.com.
Heilmann RM
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Grützner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TXMicroscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX.
Cranford SM
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Grützner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TXMicroscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX.
Holzenburg A
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Grützner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TXMicroscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX.
Suchodolski JS
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Grützner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TXMicroscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX.
Steiner JM
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Grützner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TXMicroscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX.

MeSH

AnimalsBiomarkersDog DiseasesDogsFemaleIntestinal DiseasesMaleSpecies SpecificityVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25525135

Citation

Grützner, Niels, et al. "Inflammatory, Immunological, and Intestinal Disease Biomarkers in Chinese Shar-Pei Dogs With Marked Hypocobalaminemia." Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, vol. 27, no. 1, 2015, pp. 31-40.
Grützner N, Heilmann RM, Cranford SM, et al. Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia. J Vet Diagn Invest. 2015;27(1):31-40.
Grützner, N., Heilmann, R. M., Cranford, S. M., Holzenburg, A., Suchodolski, J. S., & Steiner, J. M. (2015). Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 27(1), 31-40. https://doi.org/10.1177/1040638714560881
Grützner N, et al. Inflammatory, Immunological, and Intestinal Disease Biomarkers in Chinese Shar-Pei Dogs With Marked Hypocobalaminemia. J Vet Diagn Invest. 2015;27(1):31-40. PubMed PMID: 25525135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia. AU - Grützner,Niels, AU - Heilmann,Romy M, AU - Cranford,Shannon M, AU - Holzenburg,Andreas, AU - Suchodolski,Jan S, AU - Steiner,Jörg M, PY - 2014/12/20/entrez PY - 2014/12/20/pubmed PY - 2015/9/15/medline KW - Chinese Shar-Pei dogs KW - hypocobalaminemia KW - inflammatory markers SP - 31 EP - 40 JF - Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc JO - J Vet Diagn Invest VL - 27 IS - 1 N2 - Chinese Shar-Pei dogs have a high prevalence of hypocobalaminemia and are commonly presented with clinical signs suggestive of severe and long-standing gastrointestinal disease such as diarrhea, vomiting, and/or weight loss. The aim of the current study was to evaluate serum concentrations of inflammatory markers, markers for intestinal disease, and immunological markers in Shar-Peis with hypocobalaminemia or normocobalaminemia (serum cobalamin concentrations within the reference interval). Serum samples from Shar-Peis were collected from various parts of the United States. Serum concentrations of inflammatory markers (i.e., C-reactive protein [CRP], calprotectin [CP], and S100A12), hyaluronic acid (HA, a marker for cutaneous mucinosis), and analytes commonly altered in chronic intestinal diseases (i.e., albumin, zinc, alpha1-proteinease inhibitor [α1PI], immunoglobulin [Ig]A, and IgM) were compared between Shar-Peis with hypocobalaminemia and Shar-Peis with normocobalaminemia. Serum concentrations of CRP, CP, S100A12, HA, zinc, and cα1-PI concentrations did not differ between hypocobalaminemic and normocobalaminemic Shar-Peis (P > 0.05). Serum concentrations of albumin were significantly lower in hypocobalaminemic Shar-Peis (median: 2.5 g/dl) than in normocobalaminemic Shar-Peis (median: 2.9 g/dl; P < 0.0001). Higher serum IgA concentrations and lower serum IgM concentrations were observed in hypocobalaminemic Shar-Peis (median: 1.7 g/l and 0.8 g/l, respectively) than in normocobalaminemic Shar-Peis (median: 0.7 g/l and 1.9 g/l, respectively; both P < 0.0001). In conclusion, no difference was found in serum concentrations of CRP, CP, S100A12, and HA between hypocobalaminemic and normocobalaminemic Shar-Peis whereas some differences were observed in analytes (e.g., albumin, IgA, and IgM) that may be altered in patients with chronic enteropathies. SN - 1943-4936 UR - https://www.unboundmedicine.com/medline/citation/25525135/Inflammatory_immunological_and_intestinal_disease_biomarkers_in_Chinese_Shar_Pei_dogs_with_marked_hypocobalaminemia_ DB - PRIME DP - Unbound Medicine ER -