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Assessing photoreceptor structure after macular hole closure.
Retin Cases Brief Rep. 2015 Winter; 9(1):15-20.RC

Abstract

PURPOSE

To describe photoreceptor structure and recovery after macular hole (MH) closure with pars plana vitrectomy (PPV) using adaptive optics scanning light ophthalmoscopy and spectral domain optical coherence tomography.

METHODS

A pilot imaging study of four eyes from four subjects undergoing PPV for MH was conducted. Imaging with spectral domain optical coherence tomography and adaptive optics scanning light ophthalmoscopy was performed at varying time points after PPV.

RESULTS

Despite successful MH closure, disruption of the foveal inner segment ellipsoid zone was seen in all patients when imaged at a mean of 117 days after PPV. Disruption of the photoreceptor mosaic was seen using adaptive optics scanning light ophthalmoscopy at locations corresponding to regions of ellipsoid zone disruption on spectral domain optical coherence tomography. Cone density immediately surrounding these disruptions was normal, except for one patient. In 2 patients who were imaged serially up to 516 days after PPV, recovery of cone cells within regions of mosaic disruption could be detected over time.

CONCLUSION

Photoreceptor disruption exists even after apparent MH closure. Remodeling of the foveal cone mosaic continues for many months after surgery, perhaps accounting for the delayed postoperative improvements of visual acuity in some patients. Spectral domain optical coherence tomography and adaptive optics scanning light ophthalmoscopy are useful tools for monitoring photoreceptor recovery after surgical closure of MH.

Authors+Show Affiliations

*Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin; †Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin; ‡Department of Biomedical Engineering, University of Rochester, Rochester, New York; §Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin; and ¶Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25525907

Citation

Hansen, Sean, et al. "Assessing Photoreceptor Structure After Macular Hole Closure." Retinal Cases & Brief Reports, vol. 9, no. 1, 2015, pp. 15-20.
Hansen S, Batson S, Weinlander KM, et al. Assessing photoreceptor structure after macular hole closure. Retin Cases Brief Rep. 2015;9(1):15-20.
Hansen, S., Batson, S., Weinlander, K. M., Cooper, R. F., Scoles, D. H., Karth, P. A., Weinberg, D. V., Dubra, A., Kim, J. E., Carroll, J., & Wirostko, W. J. (2015). Assessing photoreceptor structure after macular hole closure. Retinal Cases & Brief Reports, 9(1), 15-20. https://doi.org/10.1097/ICB.0000000000000117
Hansen S, et al. Assessing Photoreceptor Structure After Macular Hole Closure. Retin Cases Brief Rep. 2015;9(1):15-20. PubMed PMID: 25525907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessing photoreceptor structure after macular hole closure. AU - Hansen,Sean, AU - Batson,Sean, AU - Weinlander,Kenneth M, AU - Cooper,Robert F, AU - Scoles,Drew H, AU - Karth,Peter A, AU - Weinberg,David V, AU - Dubra,Alfredo, AU - Kim,Judy E, AU - Carroll,Joseph, AU - Wirostko,William J, PY - 2014/12/20/entrez PY - 2014/12/20/pubmed PY - 2015/8/19/medline SP - 15 EP - 20 JF - Retinal cases & brief reports JO - Retin Cases Brief Rep VL - 9 IS - 1 N2 - PURPOSE: To describe photoreceptor structure and recovery after macular hole (MH) closure with pars plana vitrectomy (PPV) using adaptive optics scanning light ophthalmoscopy and spectral domain optical coherence tomography. METHODS: A pilot imaging study of four eyes from four subjects undergoing PPV for MH was conducted. Imaging with spectral domain optical coherence tomography and adaptive optics scanning light ophthalmoscopy was performed at varying time points after PPV. RESULTS: Despite successful MH closure, disruption of the foveal inner segment ellipsoid zone was seen in all patients when imaged at a mean of 117 days after PPV. Disruption of the photoreceptor mosaic was seen using adaptive optics scanning light ophthalmoscopy at locations corresponding to regions of ellipsoid zone disruption on spectral domain optical coherence tomography. Cone density immediately surrounding these disruptions was normal, except for one patient. In 2 patients who were imaged serially up to 516 days after PPV, recovery of cone cells within regions of mosaic disruption could be detected over time. CONCLUSION: Photoreceptor disruption exists even after apparent MH closure. Remodeling of the foveal cone mosaic continues for many months after surgery, perhaps accounting for the delayed postoperative improvements of visual acuity in some patients. Spectral domain optical coherence tomography and adaptive optics scanning light ophthalmoscopy are useful tools for monitoring photoreceptor recovery after surgical closure of MH. SN - 1937-1578 UR - https://www.unboundmedicine.com/medline/citation/25525907/Assessing_photoreceptor_structure_after_macular_hole_closure_ L2 - https://doi.org/10.1097/ICB.0000000000000117 DB - PRIME DP - Unbound Medicine ER -