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Angiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR.
Nephrol Dial Transplant. 2015 May; 30(5):762-70.ND

Abstract

BACKGROUND

Angiotensin II (AII) mediates glomerular filtration rate (GFR) decline in animals with subtotal nephrectomy (Nx), but the mechanisms for increased AII activity are unknown. Because reduced GFR of Nx is associated with acid (H(+)) retention that increases kidney AII, AII-mediated GFR decline might be induced by H(+) retention.

METHODS

We measured GFR and kidney microdialyzate H(+) and AII content in Sham and 2/3 Nx rats in response to amelioration of H(+) retention with dietary NaHCO3, to AII receptor antagonism and to both.

RESULTS

GFR was lower in Nx than that in Sham. Nx but not Sham GFR was lower at Week 24 than that at Week 1. Despite no differences in plasma acid-base parameters or urine net acid excretion, kidney H(+) content was higher in Nx than that in Sham, consistent with H(+) retention. Plasma and kidney microdialyzate AII were higher in Nx than that in Sham and dietary NaHCO3 reduced each in Nx but not in Sham. AII receptor antagonism was associated with higher Week 24 GFR in Nx with H(+) retention but not in Sham or in Nx in which H(+) retention had been corrected with dietary NaHCO3. Week 24 GFR after dietary NaHCO3 was higher than after AII receptor antagonism. Week 24 GFR was not different after adding AII receptor antagonism to dietary NaHCO3.

CONCLUSIONS

AII-mediated GFR decline in 2/3 Nx was induced by H(+) retention and its amelioration with dietary HCO3 conserved GFR better than AII receptor antagonism in this CKD model. H(+) retention might induce AII-mediated GFR decline in patients with reduced GFR, even without metabolic acidosis.

Authors+Show Affiliations

Department of Internal Medicine, Baylor Scott and White Health, Temple, TX, USA Texas A&M Health Sciences Center College of Medicine, Temple, TX, USA.Department of Biostatistics, Baylor Scott and White Health, Temple, TX, USA.Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25527741

Citation

Wesson, Donald E., et al. "Angiotensin II-mediated GFR Decline in Subtotal Nephrectomy Is Due to Acid Retention Associated With Reduced GFR." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 30, no. 5, 2015, pp. 762-70.
Wesson DE, Jo CH, Simoni J. Angiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR. Nephrol Dial Transplant. 2015;30(5):762-70.
Wesson, D. E., Jo, C. H., & Simoni, J. (2015). Angiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 30(5), 762-70. https://doi.org/10.1093/ndt/gfu388
Wesson DE, Jo CH, Simoni J. Angiotensin II-mediated GFR Decline in Subtotal Nephrectomy Is Due to Acid Retention Associated With Reduced GFR. Nephrol Dial Transplant. 2015;30(5):762-70. PubMed PMID: 25527741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR. AU - Wesson,Donald E, AU - Jo,Chan-Hee, AU - Simoni,Jan, Y1 - 2014/12/19/ PY - 2014/07/09/received PY - 2014/11/22/accepted PY - 2014/12/21/entrez PY - 2014/12/21/pubmed PY - 2015/8/1/medline KW - aldosterone KW - angiotensin II KW - bicarbonate KW - chronic kidney disease KW - endothelin KW - microdialysis SP - 762 EP - 70 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 30 IS - 5 N2 - BACKGROUND: Angiotensin II (AII) mediates glomerular filtration rate (GFR) decline in animals with subtotal nephrectomy (Nx), but the mechanisms for increased AII activity are unknown. Because reduced GFR of Nx is associated with acid (H(+)) retention that increases kidney AII, AII-mediated GFR decline might be induced by H(+) retention. METHODS: We measured GFR and kidney microdialyzate H(+) and AII content in Sham and 2/3 Nx rats in response to amelioration of H(+) retention with dietary NaHCO3, to AII receptor antagonism and to both. RESULTS: GFR was lower in Nx than that in Sham. Nx but not Sham GFR was lower at Week 24 than that at Week 1. Despite no differences in plasma acid-base parameters or urine net acid excretion, kidney H(+) content was higher in Nx than that in Sham, consistent with H(+) retention. Plasma and kidney microdialyzate AII were higher in Nx than that in Sham and dietary NaHCO3 reduced each in Nx but not in Sham. AII receptor antagonism was associated with higher Week 24 GFR in Nx with H(+) retention but not in Sham or in Nx in which H(+) retention had been corrected with dietary NaHCO3. Week 24 GFR after dietary NaHCO3 was higher than after AII receptor antagonism. Week 24 GFR was not different after adding AII receptor antagonism to dietary NaHCO3. CONCLUSIONS: AII-mediated GFR decline in 2/3 Nx was induced by H(+) retention and its amelioration with dietary HCO3 conserved GFR better than AII receptor antagonism in this CKD model. H(+) retention might induce AII-mediated GFR decline in patients with reduced GFR, even without metabolic acidosis. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/25527741/Angiotensin_II_mediated_GFR_decline_in_subtotal_nephrectomy_is_due_to_acid_retention_associated_with_reduced_GFR_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfu388 DB - PRIME DP - Unbound Medicine ER -