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Dietary consumption of advanced glycation end products and pancreatic cancer in the prospective NIH-AARP Diet and Health Study.

Abstract

BACKGROUND

Advanced glycation end products (AGEs) are a heterogeneous group of compounds present in uncooked foods as well as in foods cooked at high temperatures. AGEs have been associated with insulin resistance, oxidative stress, and chronic inflammation in patients with diabetes. Dietary AGEs are an important contributor to the AGE pool in the body. N(ϵ)-(carboxymethyl)lysine (CML) AGE is one of the major biologically and chemically well-characterized AGE markers. The consumption of red meat, which is CML-AGE rich, has been positively associated with pancreatic cancer in men.

OBJECTIVES

With the use of a published food CML-AGE database, we estimated the consumption of CML AGE in the prospective NIH-AARP Diet and Health Study and evaluated the association between CML-AGE consumption and pancreatic cancer and the mediating effect of CML AGE on the association between red meat consumption and pancreatic cancer.

DESIGN

Multivariate Cox proportional hazard regression models were used to estimate HRs and 95% CIs for pancreatic cancer.

RESULTS

During an average of 10.5 y of follow-up, we identified 2193 pancreatic cancer cases (1407 men and 786 women) from 528,251 subjects. With the comparison of subjects in the fifth and the first quintiles of CML-AGE consumption, we observed increased pancreatic cancer risk in men (HR: 1.43; 95% CI: 1.06, 1.93, P-trend = 0.003) but not women (HR: 1.14; 95% CI: 0.76, 1.72, P-trend = 0.42). Men in the highest quintile of red meat consumption had higher risk of pancreatic cancer (HR: 1.35; 95% CI: 1.07, 1.70), which attenuated after adjustment for CML-AGE consumption (HR: 1.20; 95% CI: 0.95, 1.53).

CONCLUSION

Dietary CML-AGE consumption was associated with modestly increased risk of pancreatic cancer in men and may partially explain the positive association between red meat and pancreatic cancer.

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    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    ,

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    From the Sections of Gastroenterology and Hepatology (LJ and LC) and Health Services Research (LJ, ZD, and LC), Department of Medicine, Baylor College of Medicine, Houston, TX; the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (RS-S and RS) and the Applied Research Program, Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, Rockville, MD; Westat, Rockville, MD (TPZ); Information Management Services, Rockville, MD (LK and AR); the Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom (AJC); the Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY (HV and GS); and AARP, Washington, DC (AH).

    Source

    MeSH

    Aged
    Cohort Studies
    Databases, Factual
    Diet
    Female
    Follow-Up Studies
    Glycation End Products, Advanced
    Humans
    Lysine
    Male
    Meat
    Middle Aged
    Normal Distribution
    Pancreatic Neoplasms
    Proportional Hazards Models
    Prospective Studies
    Risk
    Sex Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25527756

    Citation

    Jiao, Li, et al. "Dietary Consumption of Advanced Glycation End Products and Pancreatic Cancer in the Prospective NIH-AARP Diet and Health Study." The American Journal of Clinical Nutrition, vol. 101, no. 1, 2015, pp. 126-34.
    Jiao L, Stolzenberg-Solomon R, Zimmerman TP, et al. Dietary consumption of advanced glycation end products and pancreatic cancer in the prospective NIH-AARP Diet and Health Study. Am J Clin Nutr. 2015;101(1):126-34.
    Jiao, L., Stolzenberg-Solomon, R., Zimmerman, T. P., Duan, Z., Chen, L., Kahle, L., ... Sinha, R. (2015). Dietary consumption of advanced glycation end products and pancreatic cancer in the prospective NIH-AARP Diet and Health Study. The American Journal of Clinical Nutrition, 101(1), pp. 126-34. doi:10.3945/ajcn.114.098061.
    Jiao L, et al. Dietary Consumption of Advanced Glycation End Products and Pancreatic Cancer in the Prospective NIH-AARP Diet and Health Study. Am J Clin Nutr. 2015;101(1):126-34. PubMed PMID: 25527756.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary consumption of advanced glycation end products and pancreatic cancer in the prospective NIH-AARP Diet and Health Study. AU - Jiao,Li, AU - Stolzenberg-Solomon,Rachael, AU - Zimmerman,Thea Palmer, AU - Duan,Zhigang, AU - Chen,Liang, AU - Kahle,Lisa, AU - Risch,Adam, AU - Subar,Amy F, AU - Cross,Amanda J, AU - Hollenbeck,Albert, AU - Vlassara,Helen, AU - Striker,Gary, AU - Sinha,Rashmi, Y1 - 2014/11/19/ PY - 2014/12/21/entrez PY - 2014/12/21/pubmed PY - 2015/2/19/medline KW - advanced glycation end products KW - diet KW - inflammation KW - pancreatic cancer KW - risk SP - 126 EP - 34 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 101 IS - 1 N2 - BACKGROUND: Advanced glycation end products (AGEs) are a heterogeneous group of compounds present in uncooked foods as well as in foods cooked at high temperatures. AGEs have been associated with insulin resistance, oxidative stress, and chronic inflammation in patients with diabetes. Dietary AGEs are an important contributor to the AGE pool in the body. N(ϵ)-(carboxymethyl)lysine (CML) AGE is one of the major biologically and chemically well-characterized AGE markers. The consumption of red meat, which is CML-AGE rich, has been positively associated with pancreatic cancer in men. OBJECTIVES: With the use of a published food CML-AGE database, we estimated the consumption of CML AGE in the prospective NIH-AARP Diet and Health Study and evaluated the association between CML-AGE consumption and pancreatic cancer and the mediating effect of CML AGE on the association between red meat consumption and pancreatic cancer. DESIGN: Multivariate Cox proportional hazard regression models were used to estimate HRs and 95% CIs for pancreatic cancer. RESULTS: During an average of 10.5 y of follow-up, we identified 2193 pancreatic cancer cases (1407 men and 786 women) from 528,251 subjects. With the comparison of subjects in the fifth and the first quintiles of CML-AGE consumption, we observed increased pancreatic cancer risk in men (HR: 1.43; 95% CI: 1.06, 1.93, P-trend = 0.003) but not women (HR: 1.14; 95% CI: 0.76, 1.72, P-trend = 0.42). Men in the highest quintile of red meat consumption had higher risk of pancreatic cancer (HR: 1.35; 95% CI: 1.07, 1.70), which attenuated after adjustment for CML-AGE consumption (HR: 1.20; 95% CI: 0.95, 1.53). CONCLUSION: Dietary CML-AGE consumption was associated with modestly increased risk of pancreatic cancer in men and may partially explain the positive association between red meat and pancreatic cancer. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/25527756/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.114.098061 DB - PRIME DP - Unbound Medicine ER -