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Affective bias and current, past and future adolescent depression: a familial high risk study.
J Affect Disord. 2015 Mar 15; 174:265-71.JA

Abstract

BACKGROUND

Affective bias is a common feature of depressive disorder. However, a lack of longitudinal studies means that the temporal relationship between affective bias and depression is not well understood. One group where studies of affective bias may be particularly warranted is the adolescent offspring of depressed parents, given observations of high rates of depression and a severe and impairing course of disorder in this group.

METHODS

A two wave panel design was used in which adolescent offspring of parents with recurrent depression completed a behavioural task assessing affective bias (The Affective Go/No Go Task) and a psychiatric interview. The affective processing of adolescents with current, prior and future depressive disorder was compared to that of adolescents free from disorder.

RESULTS

Adolescents with current depression and those who developed depression at follow-up made more commission errors for sad than happy targets compared to adolescents free from disorder. There was no effect of prior depression on later affective processing.

LIMITATIONS

Small cell sizes meant we were unable to separately compare those with new onset and recurrent depressive disorder.

CONCLUSIONS

Valence-specific errors in behavioural inhibition index future vulnerability to depression in adolescents already at increased risk and may represent a measure of affective control. Currently depressed adolescents show a similar pattern of affective bias or deficits in affective control.

Authors+Show Affiliations

(a)Department of Clinical, Educational and Health Psychology, University College London, 26 Bedford Way, London WC1H 0AP, United Kingdom.(a)Department of Clinical, Educational and Health Psychology, University College London, 26 Bedford Way, London WC1H 0AP, United Kingdom.Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom.Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom.Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom.(a)Department of Clinical, Educational and Health Psychology, University College London, 26 Bedford Way, London WC1H 0AP, United Kingdom. Electronic address: f.rice@ucl.ac.uk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25527997

Citation

Kilford, Emma J., et al. "Affective Bias and Current, Past and Future Adolescent Depression: a Familial High Risk Study." Journal of Affective Disorders, vol. 174, 2015, pp. 265-71.
Kilford EJ, Foulkes L, Potter R, et al. Affective bias and current, past and future adolescent depression: a familial high risk study. J Affect Disord. 2015;174:265-71.
Kilford, E. J., Foulkes, L., Potter, R., Collishaw, S., Thapar, A., & Rice, F. (2015). Affective bias and current, past and future adolescent depression: a familial high risk study. Journal of Affective Disorders, 174, 265-71. https://doi.org/10.1016/j.jad.2014.11.046
Kilford EJ, et al. Affective Bias and Current, Past and Future Adolescent Depression: a Familial High Risk Study. J Affect Disord. 2015 Mar 15;174:265-71. PubMed PMID: 25527997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Affective bias and current, past and future adolescent depression: a familial high risk study. AU - Kilford,Emma J, AU - Foulkes,Lucy, AU - Potter,Robert, AU - Collishaw,Stephan, AU - Thapar,Anita, AU - Rice,Frances, Y1 - 2014/11/29/ PY - 2014/07/15/received PY - 2014/11/20/revised PY - 2014/11/22/accepted PY - 2014/12/22/entrez PY - 2014/12/22/pubmed PY - 2015/8/26/medline KW - Adolescence KW - Affective KW - Cognitive KW - Depression KW - High-risk KW - Longitudinal SP - 265 EP - 71 JF - Journal of affective disorders JO - J Affect Disord VL - 174 N2 - BACKGROUND: Affective bias is a common feature of depressive disorder. However, a lack of longitudinal studies means that the temporal relationship between affective bias and depression is not well understood. One group where studies of affective bias may be particularly warranted is the adolescent offspring of depressed parents, given observations of high rates of depression and a severe and impairing course of disorder in this group. METHODS: A two wave panel design was used in which adolescent offspring of parents with recurrent depression completed a behavioural task assessing affective bias (The Affective Go/No Go Task) and a psychiatric interview. The affective processing of adolescents with current, prior and future depressive disorder was compared to that of adolescents free from disorder. RESULTS: Adolescents with current depression and those who developed depression at follow-up made more commission errors for sad than happy targets compared to adolescents free from disorder. There was no effect of prior depression on later affective processing. LIMITATIONS: Small cell sizes meant we were unable to separately compare those with new onset and recurrent depressive disorder. CONCLUSIONS: Valence-specific errors in behavioural inhibition index future vulnerability to depression in adolescents already at increased risk and may represent a measure of affective control. Currently depressed adolescents show a similar pattern of affective bias or deficits in affective control. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/25527997/Affective_bias_and_current_past_and_future_adolescent_depression:_a_familial_high_risk_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(14)00756-3 DB - PRIME DP - Unbound Medicine ER -