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Serum 25-hydroxyvitamin D levels are associated with carotid atherosclerosis in normotensive and euglycemic Chinese postmenopausal women: the Shanghai Changfeng study.
BMC Cardiovasc Disord 2014; 14:197BC

Abstract

BACKGROUND

The role of serum 25-hydroxyvitamin D (25 (OH) D) in atherogenesis is unclear. We investigated whether the 25 (OH) D is independently associated with the carotid intima-media thickness (CIMT) and carotid plaques in normotensive and euglycemic postmenopausal women.

METHODS

A total of 671 normotensive and euglycemic postmenopausal women (mean age, 58.8 years) were enrolled from the Changfeng Study. A standard interview, anthropometrics measurements and laboratory analyses were performed for each participant. Bilateral CIMTs were measured using ultrasonography, and the presence of carotid plaques was assessed. The serum 25 (OH) D was measured using electrochemiluminescence immunoassay.

RESULTS

Serum 25 (OH) D was 43.6 ± 18.2 nmol/L in the postmenopausal women. Compared with subjects with 25 (OH) D in the first, second and third quartiles, subjects with 25 (OH) D in the fourth quartile had decreased CIMT and prevalence of carotid plaque (0.684 ± 0.009 mm vs 0.719 ± 0.009 mm, 0.708 ± 0.009 mm and 0.709 ± 0.009 mm; 10.8% vs 19.0%, 14.8% and 16.8%, respectively). After adjusting for conventional CVD risk factors, PTH, liver and renal function, postmenopausal women with 25 (OH) D in the fourth quartile still had lower CIMT than those in the first, second and third quartiles (p = 0.039) and the subjects in the fourth quartile had a 0.421-fold decreased risk of carotid plaques relative to those in the lowest quartile (95% confidence interval 0.209 to 0.848).

CONCLUSIONS

These results suggest serum 25 (OH) D is independently and inversely associated with carotid atherosclerosis in postmenopausal women with normal blood pressure and normal glucose tolerance.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Endocrinology and Metabolism, Zhong Shan Hospital, Fudan University, Shanghai 200032, China. zhongshan_endo@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25528383

Citation

Ma, Hui, et al. "Serum 25-hydroxyvitamin D Levels Are Associated With Carotid Atherosclerosis in Normotensive and Euglycemic Chinese Postmenopausal Women: the Shanghai Changfeng Study." BMC Cardiovascular Disorders, vol. 14, 2014, p. 197.
Ma H, Lin H, Hu Y, et al. Serum 25-hydroxyvitamin D levels are associated with carotid atherosclerosis in normotensive and euglycemic Chinese postmenopausal women: the Shanghai Changfeng study. BMC Cardiovasc Disord. 2014;14:197.
Ma, H., Lin, H., Hu, Y., Li, X., He, W., Jin, X., ... Gao, X. (2014). Serum 25-hydroxyvitamin D levels are associated with carotid atherosclerosis in normotensive and euglycemic Chinese postmenopausal women: the Shanghai Changfeng study. BMC Cardiovascular Disorders, 14, p. 197. doi:10.1186/1471-2261-14-197.
Ma H, et al. Serum 25-hydroxyvitamin D Levels Are Associated With Carotid Atherosclerosis in Normotensive and Euglycemic Chinese Postmenopausal Women: the Shanghai Changfeng Study. BMC Cardiovasc Disord. 2014 Dec 20;14:197. PubMed PMID: 25528383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D levels are associated with carotid atherosclerosis in normotensive and euglycemic Chinese postmenopausal women: the Shanghai Changfeng study. AU - Ma,Hui, AU - Lin,Huandong, AU - Hu,Yu, AU - Li,Xiaoming, AU - He,Wanyuan, AU - Jin,Xuejuan, AU - Gao,Jian, AU - Zhao,Naiqing, AU - Liu,Zhenqi, AU - Gao,Xin, Y1 - 2014/12/20/ PY - 2014/07/31/received PY - 2014/12/16/accepted PY - 2014/12/22/entrez PY - 2014/12/22/pubmed PY - 2015/8/8/medline SP - 197 EP - 197 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 14 N2 - BACKGROUND: The role of serum 25-hydroxyvitamin D (25 (OH) D) in atherogenesis is unclear. We investigated whether the 25 (OH) D is independently associated with the carotid intima-media thickness (CIMT) and carotid plaques in normotensive and euglycemic postmenopausal women. METHODS: A total of 671 normotensive and euglycemic postmenopausal women (mean age, 58.8 years) were enrolled from the Changfeng Study. A standard interview, anthropometrics measurements and laboratory analyses were performed for each participant. Bilateral CIMTs were measured using ultrasonography, and the presence of carotid plaques was assessed. The serum 25 (OH) D was measured using electrochemiluminescence immunoassay. RESULTS: Serum 25 (OH) D was 43.6 ± 18.2 nmol/L in the postmenopausal women. Compared with subjects with 25 (OH) D in the first, second and third quartiles, subjects with 25 (OH) D in the fourth quartile had decreased CIMT and prevalence of carotid plaque (0.684 ± 0.009 mm vs 0.719 ± 0.009 mm, 0.708 ± 0.009 mm and 0.709 ± 0.009 mm; 10.8% vs 19.0%, 14.8% and 16.8%, respectively). After adjusting for conventional CVD risk factors, PTH, liver and renal function, postmenopausal women with 25 (OH) D in the fourth quartile still had lower CIMT than those in the first, second and third quartiles (p = 0.039) and the subjects in the fourth quartile had a 0.421-fold decreased risk of carotid plaques relative to those in the lowest quartile (95% confidence interval 0.209 to 0.848). CONCLUSIONS: These results suggest serum 25 (OH) D is independently and inversely associated with carotid atherosclerosis in postmenopausal women with normal blood pressure and normal glucose tolerance. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/25528383/Serum_25_hydroxyvitamin_D_levels_are_associated_with_carotid_atherosclerosis_in_normotensive_and_euglycemic_Chinese_postmenopausal_women:_the_Shanghai_Changfeng_study_ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-197 DB - PRIME DP - Unbound Medicine ER -