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Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways.
Rev Neurosci. 2015; 26(2):129-42.RN

Abstract

Hydrogen sulfide (H2S) is an endogenously produced gas that represents a novel third gaseous signaling molecule, neurotransmitter and cytoprotectant. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), 3-mercaptopyruvate sulfur transferase with cysteine aminotransferase (3-MST/CAT) and 3-mercaptopyruvate sulfur transferase with d-amino acid oxidase (3-MST/DAO) pathways are involved in the generation of endogenous H2S despite the ubiquitous or restricted distribution of those enzymes. CBS, 3-MST/CAT and 3-MST/DAO can be found in the brain, while CSE is widely located in other organs. There also exist up-taking or recycling and scavenging mechanisms in H2S metabolism to maintain its persistence for physiological function. In recent years, investigating the role that H2S plays in the central nervous system and cardiovascular system has always been a hotspot. To date, effects of H2S are at least partially verified in multiple animal models or neuron cell lines of Alzheimer's disease, Parkinson's disease, cerebral ischemia, major depression disorders and febrile seizure, although subsequent studies are still badly needed. This article presents an overview of current knowledge of H2S focusing on its neuroprotective effects and corresponding signaling pathways, together with connections to potential therapeutic strategies in the clinic.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25528761

Citation

Chen, Wen-Lin, et al. "Neuroprotective Effects of Hydrogen Sulfide and the Underlying Signaling Pathways." Reviews in the Neurosciences, vol. 26, no. 2, 2015, pp. 129-42.
Chen WL, Niu YY, Jiang WZ, et al. Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways. Rev Neurosci. 2015;26(2):129-42.
Chen, W. L., Niu, Y. Y., Jiang, W. Z., Tang, H. L., Zhang, C., Xia, Q. M., & Tang, X. Q. (2015). Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways. Reviews in the Neurosciences, 26(2), 129-42. https://doi.org/10.1515/revneuro-2014-0051
Chen WL, et al. Neuroprotective Effects of Hydrogen Sulfide and the Underlying Signaling Pathways. Rev Neurosci. 2015;26(2):129-42. PubMed PMID: 25528761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways. AU - Chen,Wen-Lin, AU - Niu,Ying-Ying, AU - Jiang,Wei-Zheng, AU - Tang,Hui-Lan, AU - Zhang,Chong, AU - Xia,Qi-Ming, AU - Tang,Xiao-Qing, PY - 2014/07/25/received PY - 2014/10/01/accepted PY - 2014/12/22/entrez PY - 2014/12/22/pubmed PY - 2016/8/20/medline SP - 129 EP - 42 JF - Reviews in the neurosciences JO - Rev Neurosci VL - 26 IS - 2 N2 - Hydrogen sulfide (H2S) is an endogenously produced gas that represents a novel third gaseous signaling molecule, neurotransmitter and cytoprotectant. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), 3-mercaptopyruvate sulfur transferase with cysteine aminotransferase (3-MST/CAT) and 3-mercaptopyruvate sulfur transferase with d-amino acid oxidase (3-MST/DAO) pathways are involved in the generation of endogenous H2S despite the ubiquitous or restricted distribution of those enzymes. CBS, 3-MST/CAT and 3-MST/DAO can be found in the brain, while CSE is widely located in other organs. There also exist up-taking or recycling and scavenging mechanisms in H2S metabolism to maintain its persistence for physiological function. In recent years, investigating the role that H2S plays in the central nervous system and cardiovascular system has always been a hotspot. To date, effects of H2S are at least partially verified in multiple animal models or neuron cell lines of Alzheimer's disease, Parkinson's disease, cerebral ischemia, major depression disorders and febrile seizure, although subsequent studies are still badly needed. This article presents an overview of current knowledge of H2S focusing on its neuroprotective effects and corresponding signaling pathways, together with connections to potential therapeutic strategies in the clinic. SN - 0334-1763 UR - https://www.unboundmedicine.com/medline/citation/25528761/Neuroprotective_effects_of_hydrogen_sulfide_and_the_underlying_signaling_pathways_ L2 - https://www.degruyter.com/document/doi/10.1515/revneuro-2014-0051 DB - PRIME DP - Unbound Medicine ER -