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En face imaging of the choroid in polypoidal choroidal vasculopathy using swept-source optical coherence tomography.
Am J Ophthalmol. 2015 Apr; 159(4):634-43.AJ

Abstract

OBJECTIVE

To define morphologic features of polypoidal choroidal vasculopathy (PCV) using en face images from swept-source optical coherence tomography (SS OCT).

DESIGN

Prospective cross-sectional study.

METHODS

The study included 10 eyes from 6 patients with PCV and 10 eyes from 5 age-matched normal subjects. All subjects were prospectively scanned with a prototype SS OCT system. A motion correction algorithm was applied to correct and merge scans into a single volumetric dataset. En face images were generated at intervals of 4.13 μm (1 pixel) relative to the Bruch membrane.

RESULTS

Age ± standard deviation for the normal group was 62.4 (±12.1) years and for the PCV group was 68.3 (±5.2) years. En face SS OCT imaging of PCV eyes demonstrated the relationship between larger pigment epithelial detachments (PEDs) and small adjoining PEDs that correlated with the polypoidal lesions seen on indocyanine green angiography in all PCV eyes. En face SS OCT demonstrated choroidal vascular abnormalities in 7 out of 7 eyes with PCV, and in 2 out of 3 enrolled fellow eyes in patients with unilateral PCV. Out of 7 PCV eyes, focal choroidal vascular dilation was noted in 3 eyes and diffuse choroidal vascular dilation was noted in 1 eye. In addition, a branching vascular network was noted above the Bruch membrane in 1 eye, below the Bruch membrane within the choriocapillaris in 1 eye, and in the larger choroidal vascular layer in 1 eye.

CONCLUSIONS

En face SS OCT provides an in vivo tool to visualize the pathologic features and the choroidal vasculature in PCV.

Authors+Show Affiliations

New England Eye Center, Tufts Medical Center, Boston, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts.Pattern Recognition Lab and School of Advanced Optical Technologies, University Erlangen Nuremberg, Erlangen, Germany; Departments of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts.Pattern Recognition Lab and School of Advanced Optical Technologies, University Erlangen Nuremberg, Erlangen, Germany.Departments of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts.New England Eye Center, Tufts Medical Center, Boston, Massachusetts. Electronic address: nadiakwaheed@gmail.com.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25528955

Citation

Alasil, Tarek, et al. "En Face Imaging of the Choroid in Polypoidal Choroidal Vasculopathy Using Swept-source Optical Coherence Tomography." American Journal of Ophthalmology, vol. 159, no. 4, 2015, pp. 634-43.
Alasil T, Ferrara D, Adhi M, et al. En face imaging of the choroid in polypoidal choroidal vasculopathy using swept-source optical coherence tomography. Am J Ophthalmol. 2015;159(4):634-43.
Alasil, T., Ferrara, D., Adhi, M., Brewer, E., Kraus, M. F., Baumal, C. R., Hornegger, J., Fujimoto, J. G., Witkin, A. J., Reichel, E., Duker, J. S., & Waheed, N. K. (2015). En face imaging of the choroid in polypoidal choroidal vasculopathy using swept-source optical coherence tomography. American Journal of Ophthalmology, 159(4), 634-43. https://doi.org/10.1016/j.ajo.2014.12.012
Alasil T, et al. En Face Imaging of the Choroid in Polypoidal Choroidal Vasculopathy Using Swept-source Optical Coherence Tomography. Am J Ophthalmol. 2015;159(4):634-43. PubMed PMID: 25528955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - En face imaging of the choroid in polypoidal choroidal vasculopathy using swept-source optical coherence tomography. AU - Alasil,Tarek, AU - Ferrara,Daniela, AU - Adhi,Mehreen, AU - Brewer,Erika, AU - Kraus,Martin F, AU - Baumal,Caroline R, AU - Hornegger,Joachim, AU - Fujimoto,James G, AU - Witkin,Andre J, AU - Reichel,Elias, AU - Duker,Jay S, AU - Waheed,Nadia K, Y1 - 2014/12/19/ PY - 2014/06/29/received PY - 2014/12/12/revised PY - 2014/12/12/accepted PY - 2014/12/23/entrez PY - 2014/12/23/pubmed PY - 2015/5/15/medline SP - 634 EP - 43 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 159 IS - 4 N2 - OBJECTIVE: To define morphologic features of polypoidal choroidal vasculopathy (PCV) using en face images from swept-source optical coherence tomography (SS OCT). DESIGN: Prospective cross-sectional study. METHODS: The study included 10 eyes from 6 patients with PCV and 10 eyes from 5 age-matched normal subjects. All subjects were prospectively scanned with a prototype SS OCT system. A motion correction algorithm was applied to correct and merge scans into a single volumetric dataset. En face images were generated at intervals of 4.13 μm (1 pixel) relative to the Bruch membrane. RESULTS: Age ± standard deviation for the normal group was 62.4 (±12.1) years and for the PCV group was 68.3 (±5.2) years. En face SS OCT imaging of PCV eyes demonstrated the relationship between larger pigment epithelial detachments (PEDs) and small adjoining PEDs that correlated with the polypoidal lesions seen on indocyanine green angiography in all PCV eyes. En face SS OCT demonstrated choroidal vascular abnormalities in 7 out of 7 eyes with PCV, and in 2 out of 3 enrolled fellow eyes in patients with unilateral PCV. Out of 7 PCV eyes, focal choroidal vascular dilation was noted in 3 eyes and diffuse choroidal vascular dilation was noted in 1 eye. In addition, a branching vascular network was noted above the Bruch membrane in 1 eye, below the Bruch membrane within the choriocapillaris in 1 eye, and in the larger choroidal vascular layer in 1 eye. CONCLUSIONS: En face SS OCT provides an in vivo tool to visualize the pathologic features and the choroidal vasculature in PCV. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/25528955/En_face_imaging_of_the_choroid_in_polypoidal_choroidal_vasculopathy_using_swept_source_optical_coherence_tomography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(14)00818-6 DB - PRIME DP - Unbound Medicine ER -