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Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012-2013.
Emerg Infect Dis. 2015 Jan; 21(1):40-7.EI

Abstract

Burkholderia pseudomallei, an environmental gram-negative bacillus, is the causative agent of melioidosis and a bio-threat agent. Reports of B. pseudomallei isolation from soil and animals in East and West Africa suggest that melioidosis might be more widely distributed than previously thought. Because it has been found in equatorial areas with tropical climates, we hypothesized that B. pseudomallei could exist in Gabon. During 2012-2013, we conducted a seroprevalance study in which we set up microbiology facilities at a large clinical referral center and prospectively screened all febrile patients by conducting blood cultures and testing for B. pseudomallei and related species; we also determined whether B. pseudomallei could be isolated from soil. We discovered a novel B. pseudomallei sequence type that caused lethal septic shock and identified B. pseudomallei and B. thailandensis in the environment. Our data suggest that melioidosis is emerging in Central Africa but is unrecognized because of the lack of diagnostic microbiology facilities.

Links

Publisher Full Text
ncbi.nlm.nih.gov
dx.doi.org
PMC Free PDF

Authors

Wiersinga WJ
No affiliation info available
Birnie E
No affiliation info available
Weehuizen TA
No affiliation info available
Alabi AS
No affiliation info available
Huson MA
No affiliation info available
Huis in 't Veld RA
No affiliation info available
Mabala HK
No affiliation info available
Adzoda GK
No affiliation info available
Raczynski-Henk Y
No affiliation info available
Esen M
No affiliation info available
Lell B
No affiliation info available
Kremsner PG
No affiliation info available
Visser CE
No affiliation info available
Wuthiekanun V
No affiliation info available
Peacock SJ
No affiliation info available
van der Ende A
No affiliation info available
Limmathurotsakul D
No affiliation info available
Grobusch MP
No affiliation info available

MeSH

AdolescentAntibodies, BacterialBurkholderia pseudomalleiChildCommunity-Acquired InfectionsEnvironmental MonitoringEpidemiological MonitoringFatal OutcomeFemaleGabonHumansMaleMass ScreeningMelioidosisMiddle AgedPhylogenyPrevalenceProspective StudiesSoil MicrobiologyYoung Adult

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25530077

Citation

Wiersinga, W Joost, et al. "Clinical, Environmental, and Serologic Surveillance Studies of Melioidosis in Gabon, 2012-2013." Emerging Infectious Diseases, vol. 21, no. 1, 2015, pp. 40-7.
Wiersinga WJ, Birnie E, Weehuizen TA, et al. Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012-2013. Emerging Infect Dis. 2015;21(1):40-7.
Wiersinga, W. J., Birnie, E., Weehuizen, T. A., Alabi, A. S., Huson, M. A., Huis in 't Veld, R. A., Mabala, H. K., Adzoda, G. K., Raczynski-Henk, Y., Esen, M., Lell, B., Kremsner, P. G., Visser, C. E., Wuthiekanun, V., Peacock, S. J., van der Ende, A., Limmathurotsakul, D., & Grobusch, M. P. (2015). Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012-2013. Emerging Infectious Diseases, 21(1), 40-7. https://doi.org/10.3201/eid2101.140762
Wiersinga WJ, et al. Clinical, Environmental, and Serologic Surveillance Studies of Melioidosis in Gabon, 2012-2013. Emerging Infect Dis. 2015;21(1):40-7. PubMed PMID: 25530077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012-2013. AU - Wiersinga,W Joost, AU - Birnie,Emma, AU - Weehuizen,Tassili A F, AU - Alabi,Abraham S, AU - Huson,Michaëla A M, AU - Huis in 't Veld,Robert A G, AU - Mabala,Harry K, AU - Adzoda,Gregoire K, AU - Raczynski-Henk,Yannick, AU - Esen,Meral, AU - Lell,Bertrand, AU - Kremsner,Peter G, AU - Visser,Caroline E, AU - Wuthiekanun,Vanaporn, AU - Peacock,Sharon J, AU - van der Ende,Arie, AU - Limmathurotsakul,Direk, AU - Grobusch,Martin P, PY - 2014/12/23/entrez PY - 2014/12/23/pubmed PY - 2015/9/12/medline SP - 40 EP - 7 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 21 IS - 1 N2 - Burkholderia pseudomallei, an environmental gram-negative bacillus, is the causative agent of melioidosis and a bio-threat agent. Reports of B. pseudomallei isolation from soil and animals in East and West Africa suggest that melioidosis might be more widely distributed than previously thought. Because it has been found in equatorial areas with tropical climates, we hypothesized that B. pseudomallei could exist in Gabon. During 2012-2013, we conducted a seroprevalance study in which we set up microbiology facilities at a large clinical referral center and prospectively screened all febrile patients by conducting blood cultures and testing for B. pseudomallei and related species; we also determined whether B. pseudomallei could be isolated from soil. We discovered a novel B. pseudomallei sequence type that caused lethal septic shock and identified B. pseudomallei and B. thailandensis in the environment. Our data suggest that melioidosis is emerging in Central Africa but is unrecognized because of the lack of diagnostic microbiology facilities. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/25530077/Clinical_environmental_and_serologic_surveillance_studies_of_melioidosis_in_Gabon_2012_2013_ L2 - https://dx.doi.org/10.3201/eid2101.140762 DB - PRIME DP - Unbound Medicine ER -