Tags

Type your tag names separated by a space and hit enter

Molecular epidemiology and genetic diversity of Orientia tsutsugamushi from patients with scrub typhus in 3 regions of India.
Emerg Infect Dis. 2015 Jan; 21(1):64-9.EI

Abstract

Scrub typhus, an acute febrile illness that is widespread in the Asia-Pacific region, is caused by the bacterium Orientia tsutsugamushi, which displays high levels of antigenic variation. We conducted an investigation to identify the circulating genotypes of O. tsutsugamushi in 3 scrub typhus-endemic geographic regions of India: South India, Northern India, and Northeast India. Eschar samples collected during September 2010-August 2012 from patients with scrub typhus were subjected to 56-kDa type-specific PCR and sequencing to identify their genotypes. Kato-like strains predominated (61.5%), especially in the South and Northeast, followed by Karp-like strains (27.7%) and Gilliam and Ikeda strains (2.3% each). Neimeng-65 genotype strains were also observed in the Northeast. Clarifying the genotypic diversity of O. tsutsugamushi in India enhances knowledge of the regional diversity among circulating strains and provides potential resources for future region-specific diagnostic studies and vaccine development.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25530231

Citation

Varghese, George M., et al. "Molecular Epidemiology and Genetic Diversity of Orientia Tsutsugamushi From Patients With Scrub Typhus in 3 Regions of India." Emerging Infectious Diseases, vol. 21, no. 1, 2015, pp. 64-9.
Varghese GM, Janardhanan J, Mahajan SK, et al. Molecular epidemiology and genetic diversity of Orientia tsutsugamushi from patients with scrub typhus in 3 regions of India. Emerg Infect Dis. 2015;21(1):64-9.
Varghese, G. M., Janardhanan, J., Mahajan, S. K., Tariang, D., Trowbridge, P., Prakash, J. A., David, T., Sathendra, S., & Abraham, O. C. (2015). Molecular epidemiology and genetic diversity of Orientia tsutsugamushi from patients with scrub typhus in 3 regions of India. Emerging Infectious Diseases, 21(1), 64-9. https://doi.org/10.3201/eid2101.140580
Varghese GM, et al. Molecular Epidemiology and Genetic Diversity of Orientia Tsutsugamushi From Patients With Scrub Typhus in 3 Regions of India. Emerg Infect Dis. 2015;21(1):64-9. PubMed PMID: 25530231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular epidemiology and genetic diversity of Orientia tsutsugamushi from patients with scrub typhus in 3 regions of India. AU - Varghese,George M, AU - Janardhanan,Jeshina, AU - Mahajan,Sanjay K, AU - Tariang,David, AU - Trowbridge,Paul, AU - Prakash,John A J, AU - David,Thambu, AU - Sathendra,Sowmya, AU - Abraham,O C, PY - 2014/12/23/entrez PY - 2014/12/23/pubmed PY - 2015/9/12/medline SP - 64 EP - 9 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 21 IS - 1 N2 - Scrub typhus, an acute febrile illness that is widespread in the Asia-Pacific region, is caused by the bacterium Orientia tsutsugamushi, which displays high levels of antigenic variation. We conducted an investigation to identify the circulating genotypes of O. tsutsugamushi in 3 scrub typhus-endemic geographic regions of India: South India, Northern India, and Northeast India. Eschar samples collected during September 2010-August 2012 from patients with scrub typhus were subjected to 56-kDa type-specific PCR and sequencing to identify their genotypes. Kato-like strains predominated (61.5%), especially in the South and Northeast, followed by Karp-like strains (27.7%) and Gilliam and Ikeda strains (2.3% each). Neimeng-65 genotype strains were also observed in the Northeast. Clarifying the genotypic diversity of O. tsutsugamushi in India enhances knowledge of the regional diversity among circulating strains and provides potential resources for future region-specific diagnostic studies and vaccine development. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/25530231/Molecular_epidemiology_and_genetic_diversity_of_Orientia_tsutsugamushi_from_patients_with_scrub_typhus_in_3_regions_of_India_ L2 - https://doi.org/10.3201/eid2101.140580 DB - PRIME DP - Unbound Medicine ER -