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In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments.
Anal Chem. 2015 Feb 03; 87(3):1903-10.AC

Abstract

In this work, we report a green and simple strategy for the in situ growth of surfactant-free Au nanoparticles (Au NPs) on nitrogen-doped graphene quantum dots (Au NPs-N-GQDs). The formation of hybrid was achieved by just mixing the N-GQDs and HAuCl4·4H2O without addition of any other reductant and surfactant. High-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) characterizations clearly showed the formation of Au nanoparticles with predominantly exposed (111) facets which can provide more adsorption sites. Such nonsurfactant-capped Au NPs can provide naked catalytic surface with highly electrocatalytic activity. The Au NPs-N-GQDs exhibit high sensitivity and selectivity for electrochemical detection of hydrogen peroxide (H2O2) with a low detection limit of 0.12 μM and sensitivity of 186.22 μA/mM cm(2). Importantly, the Au NPs-N-GQDs-based electrochemical biosensor has shown great potential applications for detection of H2O2 levels in human serum samples and that released from human cervical cancer cells with satisfactory results. The present study demonstrates that such novel Au NPs-N-GQDs nanocomposite is promising for fabrication of nonenzymatic H2O2 biosensors.

Authors+Show Affiliations

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, Jilin, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25533846

Citation

Ju, Jian, and Wei Chen. "In Situ Growth of Surfactant-free Gold Nanoparticles On Nitrogen-doped Graphene Quantum Dots for Electrochemical Detection of Hydrogen Peroxide in Biological Environments." Analytical Chemistry, vol. 87, no. 3, 2015, pp. 1903-10.
Ju J, Chen W. In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments. Anal Chem. 2015;87(3):1903-10.
Ju, J., & Chen, W. (2015). In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments. Analytical Chemistry, 87(3), 1903-10. https://doi.org/10.1021/ac5041555
Ju J, Chen W. In Situ Growth of Surfactant-free Gold Nanoparticles On Nitrogen-doped Graphene Quantum Dots for Electrochemical Detection of Hydrogen Peroxide in Biological Environments. Anal Chem. 2015 Feb 3;87(3):1903-10. PubMed PMID: 25533846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments. AU - Ju,Jian, AU - Chen,Wei, Y1 - 2015/01/09/ PY - 2014/12/24/entrez PY - 2014/12/24/pubmed PY - 2015/9/10/medline SP - 1903 EP - 10 JF - Analytical chemistry JO - Anal Chem VL - 87 IS - 3 N2 - In this work, we report a green and simple strategy for the in situ growth of surfactant-free Au nanoparticles (Au NPs) on nitrogen-doped graphene quantum dots (Au NPs-N-GQDs). The formation of hybrid was achieved by just mixing the N-GQDs and HAuCl4·4H2O without addition of any other reductant and surfactant. High-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) characterizations clearly showed the formation of Au nanoparticles with predominantly exposed (111) facets which can provide more adsorption sites. Such nonsurfactant-capped Au NPs can provide naked catalytic surface with highly electrocatalytic activity. The Au NPs-N-GQDs exhibit high sensitivity and selectivity for electrochemical detection of hydrogen peroxide (H2O2) with a low detection limit of 0.12 μM and sensitivity of 186.22 μA/mM cm(2). Importantly, the Au NPs-N-GQDs-based electrochemical biosensor has shown great potential applications for detection of H2O2 levels in human serum samples and that released from human cervical cancer cells with satisfactory results. The present study demonstrates that such novel Au NPs-N-GQDs nanocomposite is promising for fabrication of nonenzymatic H2O2 biosensors. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/25533846/In_situ_growth_of_surfactant_free_gold_nanoparticles_on_nitrogen_doped_graphene_quantum_dots_for_electrochemical_detection_of_hydrogen_peroxide_in_biological_environments_ L2 - https://doi.org/10.1021/ac5041555 DB - PRIME DP - Unbound Medicine ER -