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Prevalence of Vitamin D Deficiency in Patients Undergoing Elective Spine Surgery: A Cross-Sectional Analysis.
World Neurosurg. 2015 Jun; 83(6):1114-9.WN

Abstract

OBJECTIVE

Decreased bone density secondary to osteoporosis and osteomalacia represents a significant risk factor for bony fracture and spinal instrumentation failure. We evaluated the incidence of vitamin D deficiency in patients undergoing elective spinal instrumentation to investigate which patient-level risk factors are associated with deficient vitamin D levels.

METHODS

Serum 25-OH vitamin D levels were evaluated postoperatively (<72 hours) in patients undergoing elective spinal fusion from 2011 through 2012. Patients >18 years with a diagnosis of degenerative spinal spondylosis or spinal instability treated with spinal fusion were included. Risk factors for vitamin D deficiency (<20 ng/mL) were analyzed using univariate and multiple logistic regression to identify independent predictors of deficiency.

RESULTS

The mean preoperative neck and Oswestry disability indexes of the 230 consecutive patients (mean, 57 ± 13.9 years) were 21.0 ± 9.8 and 22.2 ± 8.5, respectively. Mean 25-OH vitamin D level was 25.9 ± 12.4 ng/mL (range, 6-77 ng/mL). Sixty-nine (30.0%) patients had laboratory-confirmed vitamin D deficiency and 89 (38.9%) had laboratory-confirmed vitamin D insufficiency (20-30 ng/mL). The risk of vitamin D deficiency was greater in men (odds ratio [OR] 2.53; P = 0.009), patients aged 40-60 years (OR 2.45; P = 0.018), and those who had body mass index >40 (OR 7.55; P = 0.004), an existing diagnosis of diabetes (OR 3.29; P = 0.019), or no vitamin D supplementation (OR 4.96; P = 0.043).

CONCLUSIONS

Vitamin D deficiency was common in patients with degenerative spondylosis undergoing spinal fusion. Middle-aged patients, men, the morbidly obese, those with a history of diabetes, and those with no history of supplementation had a higher incidence of vitamin D deficiency.

Authors+Show Affiliations

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.Department of Neurosurgery, Washington University in St. Louis, St. Louis, Missouri, USA.Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.Department of Neurosurgery, Washington University in St. Louis, St. Louis, Missouri, USA. Electronic address: rayz@wudosis.wustl.edu.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

25535064

Citation

Ravindra, Vijay M., et al. "Prevalence of Vitamin D Deficiency in Patients Undergoing Elective Spine Surgery: a Cross-Sectional Analysis." World Neurosurgery, vol. 83, no. 6, 2015, pp. 1114-9.
Ravindra VM, Godzik J, Guan J, et al. Prevalence of Vitamin D Deficiency in Patients Undergoing Elective Spine Surgery: A Cross-Sectional Analysis. World Neurosurg. 2015;83(6):1114-9.
Ravindra, V. M., Godzik, J., Guan, J., Dailey, A. T., Schmidt, M. H., Bisson, E. F., Hood, R. S., & Ray, W. Z. (2015). Prevalence of Vitamin D Deficiency in Patients Undergoing Elective Spine Surgery: A Cross-Sectional Analysis. World Neurosurgery, 83(6), 1114-9. https://doi.org/10.1016/j.wneu.2014.12.031
Ravindra VM, et al. Prevalence of Vitamin D Deficiency in Patients Undergoing Elective Spine Surgery: a Cross-Sectional Analysis. World Neurosurg. 2015;83(6):1114-9. PubMed PMID: 25535064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Vitamin D Deficiency in Patients Undergoing Elective Spine Surgery: A Cross-Sectional Analysis. AU - Ravindra,Vijay M, AU - Godzik,Jakub, AU - Guan,Jian, AU - Dailey,Andrew T, AU - Schmidt,Meic H, AU - Bisson,Erica F, AU - Hood,Robert S, AU - Ray,Wilson Z, Y1 - 2014/12/19/ PY - 2014/08/05/received PY - 2014/12/15/accepted PY - 2014/12/24/entrez PY - 2014/12/24/pubmed PY - 2015/9/8/medline KW - Degenerative spondylosis KW - Fusion KW - Insufficiency KW - Osteoporosis KW - Pseudarthrosis KW - Spinal instrumentation KW - Spine KW - Vitamin D deficiency SP - 1114 EP - 9 JF - World neurosurgery JO - World Neurosurg VL - 83 IS - 6 N2 - OBJECTIVE: Decreased bone density secondary to osteoporosis and osteomalacia represents a significant risk factor for bony fracture and spinal instrumentation failure. We evaluated the incidence of vitamin D deficiency in patients undergoing elective spinal instrumentation to investigate which patient-level risk factors are associated with deficient vitamin D levels. METHODS: Serum 25-OH vitamin D levels were evaluated postoperatively (<72 hours) in patients undergoing elective spinal fusion from 2011 through 2012. Patients >18 years with a diagnosis of degenerative spinal spondylosis or spinal instability treated with spinal fusion were included. Risk factors for vitamin D deficiency (<20 ng/mL) were analyzed using univariate and multiple logistic regression to identify independent predictors of deficiency. RESULTS: The mean preoperative neck and Oswestry disability indexes of the 230 consecutive patients (mean, 57 ± 13.9 years) were 21.0 ± 9.8 and 22.2 ± 8.5, respectively. Mean 25-OH vitamin D level was 25.9 ± 12.4 ng/mL (range, 6-77 ng/mL). Sixty-nine (30.0%) patients had laboratory-confirmed vitamin D deficiency and 89 (38.9%) had laboratory-confirmed vitamin D insufficiency (20-30 ng/mL). The risk of vitamin D deficiency was greater in men (odds ratio [OR] 2.53; P = 0.009), patients aged 40-60 years (OR 2.45; P = 0.018), and those who had body mass index >40 (OR 7.55; P = 0.004), an existing diagnosis of diabetes (OR 3.29; P = 0.019), or no vitamin D supplementation (OR 4.96; P = 0.043). CONCLUSIONS: Vitamin D deficiency was common in patients with degenerative spondylosis undergoing spinal fusion. Middle-aged patients, men, the morbidly obese, those with a history of diabetes, and those with no history of supplementation had a higher incidence of vitamin D deficiency. SN - 1878-8769 UR - https://www.unboundmedicine.com/medline/citation/25535064/Prevalence_of_Vitamin_D_Deficiency_in_Patients_Undergoing_Elective_Spine_Surgery:_A_Cross_Sectional_Analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-8750(14)01402-8 DB - PRIME DP - Unbound Medicine ER -