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Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial.
Cancer 2015; 121(8):1231-40C

Abstract

BACKGROUND

Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after cancer treatment. Targeted interventions are needed to address the needs of this vulnerable group.

METHODS

This randomized trial provided the first evaluation of a brief, mindfulness-based intervention for younger breast cancer survivors designed to reduce stress, depression, and inflammatory activity. Women diagnosed with early stage breast cancer at or before age 50 who had completed cancer treatment were randomly assigned to a 6-week Mindful Awareness Practices (MAPS) intervention group (n = 39) or to a wait-list control group (n = 32). Participants completed questionnaires before and after the intervention to assess stress and depressive symptoms (primary outcomes) as well as physical symptoms, cancer-related distress, and positive outcomes. Blood samples were collected to examine genomic and circulating markers of inflammation. Participants also completed questionnaires at a 3-month follow-up assessment.

RESULTS

In linear mixed models, the MAPS intervention led to significant reductions in perceived stress (P = .004) and marginal reductions in depressive symptoms (P = .094), as well as significant reductions in proinflammatory gene expression (P = .009) and inflammatory signaling (P = .001) at postintervention. Improvements in secondary outcomes included reduced fatigue, sleep disturbance, and vasomotor symptoms and increased peace and meaning and positive affect (P < .05 for all). Intervention effects on psychological and behavioral measures were not maintained at the 3-month follow-up assessment, although reductions in cancer-related distress were observed at that assessment.

CONCLUSIONS

A brief, mindfulness-based intervention demonstrated preliminary short-term efficacy in reducing stress, behavioral symptoms, and proinflammatory signaling in younger breast cancer survivors.

Authors+Show Affiliations

Department of Psychology, University of California-Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, California; Cousins Center for Psychoneuroimmunology, University of California-Los Angeles, Los Angeles, California; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, California.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25537522

Citation

Bower, Julienne E., et al. "Mindfulness Meditation for Younger Breast Cancer Survivors: a Randomized Controlled Trial." Cancer, vol. 121, no. 8, 2015, pp. 1231-40.
Bower JE, Crosswell AD, Stanton AL, et al. Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial. Cancer. 2015;121(8):1231-40.
Bower, J. E., Crosswell, A. D., Stanton, A. L., Crespi, C. M., Winston, D., Arevalo, J., ... Ganz, P. A. (2015). Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial. Cancer, 121(8), pp. 1231-40. doi:10.1002/cncr.29194.
Bower JE, et al. Mindfulness Meditation for Younger Breast Cancer Survivors: a Randomized Controlled Trial. Cancer. 2015 Apr 15;121(8):1231-40. PubMed PMID: 25537522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial. AU - Bower,Julienne E, AU - Crosswell,Alexandra D, AU - Stanton,Annette L, AU - Crespi,Catherine M, AU - Winston,Diana, AU - Arevalo,Jesusa, AU - Ma,Jeffrey, AU - Cole,Steve W, AU - Ganz,Patricia A, Y1 - 2014/12/23/ PY - 2014/09/08/received PY - 2014/11/11/revised PY - 2014/11/12/accepted PY - 2014/12/25/entrez PY - 2014/12/30/pubmed PY - 2015/6/11/medline KW - breast cancer KW - inflammation KW - mindfulness KW - premenopausal KW - stress SP - 1231 EP - 40 JF - Cancer JO - Cancer VL - 121 IS - 8 N2 - BACKGROUND: Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after cancer treatment. Targeted interventions are needed to address the needs of this vulnerable group. METHODS: This randomized trial provided the first evaluation of a brief, mindfulness-based intervention for younger breast cancer survivors designed to reduce stress, depression, and inflammatory activity. Women diagnosed with early stage breast cancer at or before age 50 who had completed cancer treatment were randomly assigned to a 6-week Mindful Awareness Practices (MAPS) intervention group (n = 39) or to a wait-list control group (n = 32). Participants completed questionnaires before and after the intervention to assess stress and depressive symptoms (primary outcomes) as well as physical symptoms, cancer-related distress, and positive outcomes. Blood samples were collected to examine genomic and circulating markers of inflammation. Participants also completed questionnaires at a 3-month follow-up assessment. RESULTS: In linear mixed models, the MAPS intervention led to significant reductions in perceived stress (P = .004) and marginal reductions in depressive symptoms (P = .094), as well as significant reductions in proinflammatory gene expression (P = .009) and inflammatory signaling (P = .001) at postintervention. Improvements in secondary outcomes included reduced fatigue, sleep disturbance, and vasomotor symptoms and increased peace and meaning and positive affect (P < .05 for all). Intervention effects on psychological and behavioral measures were not maintained at the 3-month follow-up assessment, although reductions in cancer-related distress were observed at that assessment. CONCLUSIONS: A brief, mindfulness-based intervention demonstrated preliminary short-term efficacy in reducing stress, behavioral symptoms, and proinflammatory signaling in younger breast cancer survivors. SN - 1097-0142 UR - https://www.unboundmedicine.com/medline/citation/25537522/Mindfulness_meditation_for_younger_breast_cancer_survivors:_a_randomized_controlled_trial_ L2 - https://doi.org/10.1002/cncr.29194 DB - PRIME DP - Unbound Medicine ER -