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Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats.
Indian J Pharmacol. 2014 Nov-Dec; 46(6):627-32.IJ

Abstract

OBJECTIVES

This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with metformin on streptozotocin (STZ)-nicotinamide-induced diabetic nephropathy (DN).

MATERIALS AND METHODS

Type 2 diabetes in rats was induced with STZ-nicotinamide. The diabetic rats were treated with coenzyme Q10 (10 mg/kg, p.o.) alone or coenzyme Q10 + metformin. Various parameters of renal function tests such as serum creatinine, urea, uric acid, and markers of oxidative stress such as renal malondialdehyde (MDA) level, superoxide dismutase (SOD), and catalase (CAT) activities were measured. Tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) activity, transforming growth factor-β (TGF-β), and nitrite content were estimated in renal tissues. All treated animal were subjected to histopathological changes of kidney.

RESULT

Diabetic rats showed a significant reduction in renal function, which was reflected with an increase in serum urea, serum creatinine, uric acid. In addition, STZ-nicotinamide caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity and glutathione (GSH) level. Moreover, TNF-α, MPO activity, TGF-β, and nitrite content were significantly increased in diabetic rats, while treatment with coenzyme Q10 or metformin or their combination ameliorate STZ-nicotinamide induced renal damage due to improvement in renal function, oxidative stress, suppression of TNF-α, MPO activity, TGF-β and nitrite content along with histopathological changes.

CONCLUSIONS

This finding suggests that the treatment with coenzyme Q10 or metformin showed significant renoprotective effect against STZ-nicotinamide-induced DN. However, concomitant administration of both showed a better renoprotective effect than coenzyme Q10 or metformin alone treatment.

Authors+Show Affiliations

Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25538335

Citation

Maheshwari, Rajesh A., et al. "Effect of Coenzyme Q10 Alone and Its Combination With Metformin On Streptozotocin-nicotinamide-induced Diabetic Nephropathy in Rats." Indian Journal of Pharmacology, vol. 46, no. 6, 2014, pp. 627-32.
Maheshwari RA, Balaraman R, Sen AK, et al. Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. Indian J Pharmacol. 2014;46(6):627-32.
Maheshwari, R. A., Balaraman, R., Sen, A. K., & Seth, A. K. (2014). Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. Indian Journal of Pharmacology, 46(6), 627-32. https://doi.org/10.4103/0253-7613.144924
Maheshwari RA, et al. Effect of Coenzyme Q10 Alone and Its Combination With Metformin On Streptozotocin-nicotinamide-induced Diabetic Nephropathy in Rats. Indian J Pharmacol. 2014 Nov-Dec;46(6):627-32. PubMed PMID: 25538335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. AU - Maheshwari,Rajesh A, AU - Balaraman,R, AU - Sen,Ashim K, AU - Seth,A K, PY - 2014/06/09/received PY - 2014/08/24/revised PY - 2014/10/21/accepted PY - 2014/12/25/entrez PY - 2014/12/30/pubmed PY - 2015/9/1/medline KW - Coenzyme Q10 KW - diabetic nephropathy KW - metformin KW - transforming growth factor-β KW - tumor necrosis factor-α SP - 627 EP - 32 JF - Indian journal of pharmacology JO - Indian J Pharmacol VL - 46 IS - 6 N2 - OBJECTIVES: This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with metformin on streptozotocin (STZ)-nicotinamide-induced diabetic nephropathy (DN). MATERIALS AND METHODS: Type 2 diabetes in rats was induced with STZ-nicotinamide. The diabetic rats were treated with coenzyme Q10 (10 mg/kg, p.o.) alone or coenzyme Q10 + metformin. Various parameters of renal function tests such as serum creatinine, urea, uric acid, and markers of oxidative stress such as renal malondialdehyde (MDA) level, superoxide dismutase (SOD), and catalase (CAT) activities were measured. Tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) activity, transforming growth factor-β (TGF-β), and nitrite content were estimated in renal tissues. All treated animal were subjected to histopathological changes of kidney. RESULT: Diabetic rats showed a significant reduction in renal function, which was reflected with an increase in serum urea, serum creatinine, uric acid. In addition, STZ-nicotinamide caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity and glutathione (GSH) level. Moreover, TNF-α, MPO activity, TGF-β, and nitrite content were significantly increased in diabetic rats, while treatment with coenzyme Q10 or metformin or their combination ameliorate STZ-nicotinamide induced renal damage due to improvement in renal function, oxidative stress, suppression of TNF-α, MPO activity, TGF-β and nitrite content along with histopathological changes. CONCLUSIONS: This finding suggests that the treatment with coenzyme Q10 or metformin showed significant renoprotective effect against STZ-nicotinamide-induced DN. However, concomitant administration of both showed a better renoprotective effect than coenzyme Q10 or metformin alone treatment. SN - 1998-3751 UR - https://www.unboundmedicine.com/medline/citation/25538335/Effect_of_coenzyme_Q10_alone_and_its_combination_with_metformin_on_streptozotocin_nicotinamide_induced_diabetic_nephropathy_in_rats_ L2 - http://www.ijp-online.com/article.asp?issn=0253-7613;year=2014;volume=46;issue=6;spage=627;epage=632;aulast=Maheshwari DB - PRIME DP - Unbound Medicine ER -