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Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy.
Cogn Behav Neurol. 2014 Dec; 27(4):215-21.CB

Abstract

Korsakoff syndrome is a chronic form of amnesia resulting from thiamine deficiency. The syndrome can develop from unrecognized or undertreated Wernicke encephalopathy. The intra-individual course of Wernicke-Korsakoff syndrome has not been studied extensively, nor has the temporal progression of gait disturbances and other symptoms of Wernicke encephalopathy. Here we present the detailed history of a patient whose acute symptoms of Wernicke encephalopathy were far from stable. We follow his mobility changes and the shifts in his mental status from global confusion and impaired consciousness to more selective cognitive deficits. His Wernicke encephalopathy was missed and left untreated, being labeled as "probable" Korsakoff syndrome. Patients with a history of self-neglect and alcohol abuse, at risk of or suffering with Wernicke encephalopathy, should receive immediate and adequate vitamin replacement. Self-neglecting alcoholics who are bedridden may have severe illness and probably active Wernicke encephalopathy. In these patients, mobility changes, delirium, or impaired consciousness can be an expression of Wernicke encephalopathy, and should be treated to prevent further damage from the neurologic complications of thiamine deficiency.

Authors+Show Affiliations

*Lelie Care Group, Slingedael Korsakoff Center, Rotterdam, The Netherlands †Lelie Care Group, Slingedael Korsakoff Center; and Helmholtz Institute, Utrecht University, Utrecht, The Netherlands ‡Atlant Care Group, Nursing Home Markenhof, Beekbergen, The Netherlands §Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands ∥Epidemiological and Social Psychiatric Research institute (ESPRi), Erasmus University Medical Center, Department of Psychiatry; and Parnassia Psychiatric Institute, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25539041

Citation

Wijnia, Jan W., et al. "Need for Early Diagnosis of Mental and Mobility Changes in Wernicke Encephalopathy." Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, vol. 27, no. 4, 2014, pp. 215-21.
Wijnia JW, Oudman E, Bresser EL, et al. Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy. Cogn Behav Neurol. 2014;27(4):215-21.
Wijnia, J. W., Oudman, E., Bresser, E. L., Gerridzen, I. J., van de Wiel, A., Beuman, C., & Mulder, C. L. (2014). Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy. Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, 27(4), 215-21. https://doi.org/10.1097/WNN.0000000000000041
Wijnia JW, et al. Need for Early Diagnosis of Mental and Mobility Changes in Wernicke Encephalopathy. Cogn Behav Neurol. 2014;27(4):215-21. PubMed PMID: 25539041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Need for early diagnosis of mental and mobility changes in Wernicke encephalopathy. AU - Wijnia,Jan W, AU - Oudman,Erik, AU - Bresser,Esmay L, AU - Gerridzen,Ineke J, AU - van de Wiel,Albert, AU - Beuman,Carla, AU - Mulder,Cornelis L, PY - 2014/12/25/entrez PY - 2014/12/30/pubmed PY - 2015/3/26/medline SP - 215 EP - 21 JF - Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology JO - Cogn Behav Neurol VL - 27 IS - 4 N2 - Korsakoff syndrome is a chronic form of amnesia resulting from thiamine deficiency. The syndrome can develop from unrecognized or undertreated Wernicke encephalopathy. The intra-individual course of Wernicke-Korsakoff syndrome has not been studied extensively, nor has the temporal progression of gait disturbances and other symptoms of Wernicke encephalopathy. Here we present the detailed history of a patient whose acute symptoms of Wernicke encephalopathy were far from stable. We follow his mobility changes and the shifts in his mental status from global confusion and impaired consciousness to more selective cognitive deficits. His Wernicke encephalopathy was missed and left untreated, being labeled as "probable" Korsakoff syndrome. Patients with a history of self-neglect and alcohol abuse, at risk of or suffering with Wernicke encephalopathy, should receive immediate and adequate vitamin replacement. Self-neglecting alcoholics who are bedridden may have severe illness and probably active Wernicke encephalopathy. In these patients, mobility changes, delirium, or impaired consciousness can be an expression of Wernicke encephalopathy, and should be treated to prevent further damage from the neurologic complications of thiamine deficiency. SN - 1543-3641 UR - https://www.unboundmedicine.com/medline/citation/25539041/Need_for_early_diagnosis_of_mental_and_mobility_changes_in_Wernicke_encephalopathy_ L2 - https://doi.org/10.1097/WNN.0000000000000041 DB - PRIME DP - Unbound Medicine ER -