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Acute 3,4-methylenedioxy-N-ethylcathinone (ethylone) intoxication and related fatality: a case report with postmortem concentrations.
J Anal Toxicol 2015; 39(3):225-8JA

Abstract

A 30-year-old man reportedly ingested pills and used illicit drugs with another person. They both fell asleep that night and the following afternoon the other person found him dead. There were used hypodermic needles and a metal spoon with dark tarry substance at the death scene, and two recent puncture sites were found on his body. It was uncertain if he had a history of illicit drug use. Postmortem blood initially screened borderline positive for methamphetamine by ELISA. An alkaline drug screen-detected ethylone which was subsequently confirmed and quantified by a specific GC-MS SIM analysis following solid-phase extraction. Concentrations were determined in the peripheral blood (0.39 mg/L), central blood (0.38 mg/L), liver (1.4 mg/kg), vitreous (0.58 mg/L), urine (20 mg/L) and gastric contents (12 mg). Other compounds detected in peripheral blood were morphine (0.05 mg/L), alprazolam (<0.05 mg/L), delta-9-THC (<1 ng/mL), delta-9-carboxy-THC (3.6 ng/mL) and naproxen (<5 mg/L). A urine screen (GC-MS) also confirmed 6-monoacetylmorphine, codeine and sildenafil. The cause of death was certified due to mixed ethylone, heroin and alprazolam intoxication. The manner of death was certified as accident.

Authors+Show Affiliations

County of San Diego Medical Examiner's Office, 5570 Overland Avenue, Suite 101, San Diego, CA 92123, USA iain.mcintyre@sdcounty.ca.gov.County of San Diego Medical Examiner's Office, 5570 Overland Avenue, Suite 101, San Diego, CA 92123, USA.County of San Diego Medical Examiner's Office, 5570 Overland Avenue, Suite 101, San Diego, CA 92123, USA.County of San Diego Medical Examiner's Office, 5570 Overland Avenue, Suite 101, San Diego, CA 92123, USA.County of San Diego Medical Examiner's Office, 5570 Overland Avenue, Suite 101, San Diego, CA 92123, USA.County of San Diego Medical Examiner's Office, 5570 Overland Avenue, Suite 101, San Diego, CA 92123, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25540061

Citation

McIntyre, Iain M., et al. "Acute 3,4-methylenedioxy-N-ethylcathinone (ethylone) Intoxication and Related Fatality: a Case Report With Postmortem Concentrations." Journal of Analytical Toxicology, vol. 39, no. 3, 2015, pp. 225-8.
McIntyre IM, Hamm CE, Sherrard JL, et al. Acute 3,4-methylenedioxy-N-ethylcathinone (ethylone) intoxication and related fatality: a case report with postmortem concentrations. J Anal Toxicol. 2015;39(3):225-8.
McIntyre, I. M., Hamm, C. E., Sherrard, J. L., Gary, R. D., Burton, C. G., & Mena, O. (2015). Acute 3,4-methylenedioxy-N-ethylcathinone (ethylone) intoxication and related fatality: a case report with postmortem concentrations. Journal of Analytical Toxicology, 39(3), pp. 225-8. doi:10.1093/jat/bku146.
McIntyre IM, et al. Acute 3,4-methylenedioxy-N-ethylcathinone (ethylone) Intoxication and Related Fatality: a Case Report With Postmortem Concentrations. J Anal Toxicol. 2015;39(3):225-8. PubMed PMID: 25540061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute 3,4-methylenedioxy-N-ethylcathinone (ethylone) intoxication and related fatality: a case report with postmortem concentrations. AU - McIntyre,Iain M, AU - Hamm,Catherine E, AU - Sherrard,James L, AU - Gary,Ray D, AU - Burton,Christopher G, AU - Mena,Othon, Y1 - 2014/12/23/ PY - 2014/12/26/entrez PY - 2014/12/30/pubmed PY - 2016/3/5/medline SP - 225 EP - 8 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 39 IS - 3 N2 - A 30-year-old man reportedly ingested pills and used illicit drugs with another person. They both fell asleep that night and the following afternoon the other person found him dead. There were used hypodermic needles and a metal spoon with dark tarry substance at the death scene, and two recent puncture sites were found on his body. It was uncertain if he had a history of illicit drug use. Postmortem blood initially screened borderline positive for methamphetamine by ELISA. An alkaline drug screen-detected ethylone which was subsequently confirmed and quantified by a specific GC-MS SIM analysis following solid-phase extraction. Concentrations were determined in the peripheral blood (0.39 mg/L), central blood (0.38 mg/L), liver (1.4 mg/kg), vitreous (0.58 mg/L), urine (20 mg/L) and gastric contents (12 mg). Other compounds detected in peripheral blood were morphine (0.05 mg/L), alprazolam (<0.05 mg/L), delta-9-THC (<1 ng/mL), delta-9-carboxy-THC (3.6 ng/mL) and naproxen (<5 mg/L). A urine screen (GC-MS) also confirmed 6-monoacetylmorphine, codeine and sildenafil. The cause of death was certified due to mixed ethylone, heroin and alprazolam intoxication. The manner of death was certified as accident. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/25540061/Acute_34_methylenedioxy_N_ethylcathinone__ethylone__intoxication_and_related_fatality:_a_case_report_with_postmortem_concentrations_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bku146 DB - PRIME DP - Unbound Medicine ER -