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Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide.
Org Lett. 2015 Jan 16; 17(2):298-301.OL

Abstract

A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the "CuCF3" species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li X
Key Laboratory of Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, China.
Zhao J
No affiliation info available
Zhang L
No affiliation info available
Hu M
No affiliation info available
Wang L
No affiliation info available
Hu J
No affiliation info available

MeSH

AlkynesBromidesCatalysisCopperIodidesMethylationMolecular StructureOrganometallic CompoundsOxidation-ReductionSulfoxides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25541645

Citation

Li, Xinjin, et al. "Copper-mediated Trifluoromethylation Using Phenyl Trifluoromethyl Sulfoxide." Organic Letters, vol. 17, no. 2, 2015, pp. 298-301.
Li X, Zhao J, Zhang L, et al. Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide. Org Lett. 2015;17(2):298-301.
Li, X., Zhao, J., Zhang, L., Hu, M., Wang, L., & Hu, J. (2015). Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide. Organic Letters, 17(2), 298-301. https://doi.org/10.1021/ol5034018
Li X, et al. Copper-mediated Trifluoromethylation Using Phenyl Trifluoromethyl Sulfoxide. Org Lett. 2015 Jan 16;17(2):298-301. PubMed PMID: 25541645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide. AU - Li,Xinjin, AU - Zhao,Jingwei, AU - Zhang,Liang, AU - Hu,Mingyou, AU - Wang,Limin, AU - Hu,Jinbo, Y1 - 2014/12/26/ PY - 2014/12/27/entrez PY - 2014/12/30/pubmed PY - 2015/8/26/medline SP - 298 EP - 301 JF - Organic letters JO - Org Lett VL - 17 IS - 2 N2 - A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the "CuCF3" species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/25541645/Copper_mediated_trifluoromethylation_using_phenyl_trifluoromethyl_sulfoxide_ DB - PRIME DP - Unbound Medicine ER -