TY - JOUR T1 - Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ). AU - Rebhun,John F, AU - Roloff,Samantha J, AU - Velliquette,Rodney A, AU - Missler,Stephen R, Y1 - 2014/12/24/ PY - 2014/11/14/received PY - 2014/12/10/revised PY - 2014/12/16/accepted PY - 2014/12/28/entrez PY - 2014/12/30/pubmed PY - 2015/5/30/medline KW - Evodia fruit extract KW - Evodia rutaecarpa Benth KW - Evodiamine KW - Peroxisome proliferator-activated receptor gamma KW - Rutaecarpine SP - 57 EP - 63 JF - Fitoterapia JO - Fitoterapia VL - 101 N2 - The dried unripe fruit from Evodia rutaecarpa Benth., known as Wu zhu yu in China, has long been used in traditional Chinese medicine. In this research, we provide evidence that evodia fruit extract activates peroxisome proliferator-activated receptor gamma (PPARγ) and, as identified through HPLC fractionation and mass spectroscopy, the activating phytochemical is evodiamine. Evodiamine was shown to bind to and activate PPARγ. It was also shown to activate PPARγ-regulated gene expression in human hepatoma cells similar to known PPARγ ligands and that the expression was blocked by a PPARγ specific antagonist. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/25542684/Identification_of_evodiamine_as_the_bioactive_compound_in_evodia__Evodia_rutaecarpa_Benth___fruit_extract_that_activates_human_peroxisome_proliferator_activated_receptor_gamma__PPARγ__ DB - PRIME DP - Unbound Medicine ER -