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A family history of Type 1 alcoholism differentiates alcohol consumption in high cortisol responders to stress.
Pharmacol Biochem Behav 2015; 130:59-66PB

Abstract

BACKGROUND

The differentiation between high and low cortisol responders to stress is of interest in determining the risk factors which may, along with genetic vulnerability, influence alcohol intake.

RESULTS

There were no differences in consumption of alcohol or placebo between FHP and FHN subjects. STUDY 2:

METHODS

Fifty-eight healthy social drinkers, FHP (n = 27) and FHN (n = 31) attended two laboratory sessions. They were administered either alcohol or placebo in both sessions they attended. All subjects underwent either a stress task (the Trier Social Stress Test, TSST) or a stress-free period, at two separate occasions, before being offered beverage. After the salivary cortisol analysis, subjects in each group were divided into high (HCR) or low (LCR) cortisol responders.

RESULTS

After stress, subjects who were FHP-HCR consumed more alcohol than FHN-HCR. There were no differences in the placebo intake between FHP and FHN subjects regardless of their cortisol response.

CONCLUSIONS

This result indicates that stress promotes alcohol consumption only in subjects with a family history of Type 1 alcoholism who show an increase in cortisol response to stress. This behaviour is similar to that previously observed in alcohol dependent individuals after stress and thus could represent an endophenotype posing a risk for future development of alcohol use disorders.

Authors+Show Affiliations

Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Beroendekliniken, Sahlgrenska University Hospital, Gothenburg, Sweden.Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. Electronic address: anna.soderpalm@neuro.gu.se.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25543065

Citation

Brkic, Sejla, et al. "A Family History of Type 1 Alcoholism Differentiates Alcohol Consumption in High Cortisol Responders to Stress." Pharmacology, Biochemistry, and Behavior, vol. 130, 2015, pp. 59-66.
Brkic S, Söderpalm B, Söderpalm Gordh A. A family history of Type 1 alcoholism differentiates alcohol consumption in high cortisol responders to stress. Pharmacol Biochem Behav. 2015;130:59-66.
Brkic, S., Söderpalm, B., & Söderpalm Gordh, A. (2015). A family history of Type 1 alcoholism differentiates alcohol consumption in high cortisol responders to stress. Pharmacology, Biochemistry, and Behavior, 130, pp. 59-66. doi:10.1016/j.pbb.2014.12.008.
Brkic S, Söderpalm B, Söderpalm Gordh A. A Family History of Type 1 Alcoholism Differentiates Alcohol Consumption in High Cortisol Responders to Stress. Pharmacol Biochem Behav. 2015;130:59-66. PubMed PMID: 25543065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A family history of Type 1 alcoholism differentiates alcohol consumption in high cortisol responders to stress. AU - Brkic,Sejla, AU - Söderpalm,Bo, AU - Söderpalm Gordh,Anna, Y1 - 2014/12/24/ PY - 2014/07/04/received PY - 2014/11/21/revised PY - 2014/12/18/accepted PY - 2014/12/28/entrez PY - 2014/12/30/pubmed PY - 2015/12/24/medline KW - Alcohol KW - Family history of alcoholism KW - High and low cortisol responders KW - Stress KW - TSST SP - 59 EP - 66 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 130 N2 - BACKGROUND: The differentiation between high and low cortisol responders to stress is of interest in determining the risk factors which may, along with genetic vulnerability, influence alcohol intake. RESULTS: There were no differences in consumption of alcohol or placebo between FHP and FHN subjects. STUDY 2: METHODS: Fifty-eight healthy social drinkers, FHP (n = 27) and FHN (n = 31) attended two laboratory sessions. They were administered either alcohol or placebo in both sessions they attended. All subjects underwent either a stress task (the Trier Social Stress Test, TSST) or a stress-free period, at two separate occasions, before being offered beverage. After the salivary cortisol analysis, subjects in each group were divided into high (HCR) or low (LCR) cortisol responders. RESULTS: After stress, subjects who were FHP-HCR consumed more alcohol than FHN-HCR. There were no differences in the placebo intake between FHP and FHN subjects regardless of their cortisol response. CONCLUSIONS: This result indicates that stress promotes alcohol consumption only in subjects with a family history of Type 1 alcoholism who show an increase in cortisol response to stress. This behaviour is similar to that previously observed in alcohol dependent individuals after stress and thus could represent an endophenotype posing a risk for future development of alcohol use disorders. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/25543065/A_family_history_of_Type_1_alcoholism_differentiates_alcohol_consumption_in_high_cortisol_responders_to_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(14)00346-3 DB - PRIME DP - Unbound Medicine ER -