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Vitamin D from different sources is inversely associated with Parkinson disease.
Mov Disord. 2015 Apr; 30(4):560-6.MD

Abstract

An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography-tandem mass spectrometry in PD patients (n = 478) and controls (n = 431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles. Vitamin D deficiency (total 25[OH]D < 20 ng/mL) and vitamin D insufficiency (total 25[OH]D < 30 ng/mL) are associated with PD risk (odds ratio [OR] = 2.6 [deficiency] and 2.1 [insufficiency]; P < 0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (P(trend) < 0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (P(trend) = 0.0008 and 0.12 in individuals with 25[OH]D3 < 20 ng/mL and 25[OH]D3 ≥ 20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients.

Authors+Show Affiliations

John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25545356

Citation

Wang, Liyong, et al. "Vitamin D From Different Sources Is Inversely Associated With Parkinson Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 30, no. 4, 2015, pp. 560-6.
Wang L, Evatt ML, Maldonado LG, et al. Vitamin D from different sources is inversely associated with Parkinson disease. Mov Disord. 2015;30(4):560-6.
Wang, L., Evatt, M. L., Maldonado, L. G., Perry, W. R., Ritchie, J. C., Beecham, G. W., Martin, E. R., Haines, J. L., Pericak-Vance, M. A., Vance, J. M., & Scott, W. K. (2015). Vitamin D from different sources is inversely associated with Parkinson disease. Movement Disorders : Official Journal of the Movement Disorder Society, 30(4), 560-6. https://doi.org/10.1002/mds.26117
Wang L, et al. Vitamin D From Different Sources Is Inversely Associated With Parkinson Disease. Mov Disord. 2015;30(4):560-6. PubMed PMID: 25545356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D from different sources is inversely associated with Parkinson disease. AU - Wang,Liyong, AU - Evatt,Marian L, AU - Maldonado,Lizmarie G, AU - Perry,William R, AU - Ritchie,James C, AU - Beecham,Gary W, AU - Martin,Eden R, AU - Haines,Jonathan L, AU - Pericak-Vance,Margaret A, AU - Vance,Jeffery M, AU - Scott,William K, Y1 - 2014/12/27/ PY - 2014/05/20/received PY - 2014/10/17/revised PY - 2014/10/23/accepted PY - 2014/12/30/entrez PY - 2014/12/30/pubmed PY - 2015/12/22/medline KW - Parkinson's disease KW - diet KW - vitamin D KW - vitamin D2 SP - 560 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 30 IS - 4 N2 - An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography-tandem mass spectrometry in PD patients (n = 478) and controls (n = 431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles. Vitamin D deficiency (total 25[OH]D < 20 ng/mL) and vitamin D insufficiency (total 25[OH]D < 30 ng/mL) are associated with PD risk (odds ratio [OR] = 2.6 [deficiency] and 2.1 [insufficiency]; P < 0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (P(trend) < 0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (P(trend) = 0.0008 and 0.12 in individuals with 25[OH]D3 < 20 ng/mL and 25[OH]D3 ≥ 20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/25545356/Vitamin_D_from_different_sources_is_inversely_associated_with_Parkinson_disease_ L2 - https://doi.org/10.1002/mds.26117 DB - PRIME DP - Unbound Medicine ER -