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Role of dietary pro-oxidants in the maintenance of health and resilience to oxidative stress.
Mol Nutr Food Res. 2015 Jul; 59(7):1229-48.MN

Abstract

The average length of human life is increasing, but so does the incidence of age- and lifestyle-related diseases. Improving diet and lifestyle is a key strategy for lifelong health and underlying mechanisms may well include increasing resilience pathways. The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. An increasing number of in vivo studies have now shown that dietary pro-oxidant compounds can increase the production of such resilience products. In most studies, dietary pro-oxidants normalized levels of antioxidant enzymes that were decreased by a range of different challenges, rather than raising levels of resilience products per se. Also, it is important to consider that the antioxidant response can be different for different organs. For future studies, however, the measurement of resilience markers may significantly improve our ability to prove the efficacy by which dietary bioactives with pro-oxidant capacities improve lifelong health.

Authors+Show Affiliations

Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25546122

Citation

de Roos, Baukje, and Garry G. Duthie. "Role of Dietary Pro-oxidants in the Maintenance of Health and Resilience to Oxidative Stress." Molecular Nutrition & Food Research, vol. 59, no. 7, 2015, pp. 1229-48.
de Roos B, Duthie GG. Role of dietary pro-oxidants in the maintenance of health and resilience to oxidative stress. Mol Nutr Food Res. 2015;59(7):1229-48.
de Roos, B., & Duthie, G. G. (2015). Role of dietary pro-oxidants in the maintenance of health and resilience to oxidative stress. Molecular Nutrition & Food Research, 59(7), 1229-48. https://doi.org/10.1002/mnfr.201400568
de Roos B, Duthie GG. Role of Dietary Pro-oxidants in the Maintenance of Health and Resilience to Oxidative Stress. Mol Nutr Food Res. 2015;59(7):1229-48. PubMed PMID: 25546122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of dietary pro-oxidants in the maintenance of health and resilience to oxidative stress. AU - de Roos,Baukje, AU - Duthie,Garry G, Y1 - 2015/01/22/ PY - 2014/08/15/received PY - 2014/11/26/revised PY - 2014/11/27/accepted PY - 2014/12/30/entrez PY - 2014/12/30/pubmed PY - 2016/4/27/medline KW - Antioxidants KW - Dietary fatty acids KW - Oxidative stress KW - Polyphenols KW - Resilience SP - 1229 EP - 48 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 59 IS - 7 N2 - The average length of human life is increasing, but so does the incidence of age- and lifestyle-related diseases. Improving diet and lifestyle is a key strategy for lifelong health and underlying mechanisms may well include increasing resilience pathways. The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. An increasing number of in vivo studies have now shown that dietary pro-oxidant compounds can increase the production of such resilience products. In most studies, dietary pro-oxidants normalized levels of antioxidant enzymes that were decreased by a range of different challenges, rather than raising levels of resilience products per se. Also, it is important to consider that the antioxidant response can be different for different organs. For future studies, however, the measurement of resilience markers may significantly improve our ability to prove the efficacy by which dietary bioactives with pro-oxidant capacities improve lifelong health. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/25546122/Role_of_dietary_pro_oxidants_in_the_maintenance_of_health_and_resilience_to_oxidative_stress_ L2 - https://doi.org/10.1002/mnfr.201400568 DB - PRIME DP - Unbound Medicine ER -