TY - JOUR T1 - Advances in pharmacotherapy for the treatment of gout. AU - Robinson,Philip C, AU - Dalbeth,Nicola, Y1 - 2014/12/30/ PY - 2014/12/31/entrez PY - 2014/12/31/pubmed PY - 2015/6/16/medline KW - allopurinol KW - febuxostat KW - gout KW - pegloticase KW - probenecid KW - urate SP - 533 EP - 46 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 16 IS - 4 N2 - INTRODUCTION: Gout is a common inflammatory arthritis affecting almost 6% of US males and 2% of US females. The central cause of gout is deposition of monosodium urate crystals, and the focus of treatment is aimed at crystal dissolution using urate-lowering therapy. AREAS COVERED: The review describes the current treatments for urate-lowering therapy including allopurinol, febuxostat, probenecid, benzbromarone and pegloticase. Anti-inflammatory treatment of acute flares and prophylaxis of flares with NSAIDs, colchicine, corticosteroids and anti-IL-1 agents is also reviewed. In addition, drugs in Phase III clinical trials for gout indications are reviewed. EXPERT OPINION: In the last decade, there has been major progress in the pharmacotherapy of gout. Management guidelines have emphasized the importance of a therapeutic serum urate target for effective gout management. Studies have identified the safe and effective dosing strategies for 'old' drugs such as allopurinol and colchicine. New therapeutic agents have been developed and approved for both urate-lowering therapy and anti-inflammatory treatment of acute flares. However, quality of care remains a major challenge in gout management, and strategies to ensure best practice require further focus to ensure that the progress of the last decade translates into clinical benefit for people with gout. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/25547991/Advances_in_pharmacotherapy_for_the_treatment_of_gout_ DB - PRIME DP - Unbound Medicine ER -