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Defining sarcopenia in terms of incident adverse outcomes.
J Am Med Dir Assoc. 2015 Mar; 16(3):247-52.JA

Abstract

OBJECTIVES

The objectives of this study were to compare the performance of different diagnoses of sarcopenia using European Working Group on Sarcopenia in Older People, International Working Group on Sarcopenia, and the US Foundation of National Institutes of Health (FNIH) criteria, and the screening tool SARC-F, against the Asian Working Group for Sarcopenia consensus panel definitions, in predicting physical limitation, slow walking speed, and repeated chair stand performance, days of hospital stay and mortality at follow up.

DESIGN

Longitudinal study.

SETTING

Community survey in Hong Kong.

PARTICIPANTS

Participants were 4000 men and women 65 years and older living in the community.

MEASUREMENTS

Information from questionnaire regarding activities of daily living, physical functioning limitations, and constituent questions of SARC-F; body mass index (BMI), grip strength (GS), walking speed, and appendicular muscle mass (ASM).

RESULTS

FNIH, consensus panel definitions, and the screening tool SARC-F all have similar AUC values in predicting incident physical limitation and physical performance measures at 4 years, walking speed at 7 years, days of hospital stay at 7 years, and mortality at 10 years. None of the definitions predicted increase in physical limitation at 4 years or mortality at 10 years in women, and none predicted all the adverse outcomes. The highest AUC values were observed for walking speed at 4 and 7 years.

CONCLUSION

When applied to a Chinese elderly population, criteria used for diagnosis of sarcopenia derived from European, Asian, and international consensus panels, from US cutoff values defined from incident physical limitation, and the SARC-F screening tool, all have similar performance in predicting incident physical limitation and mortality.

Authors+Show Affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address: jeanwoowong@cuhk.edu.hk.The Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Hong Kong.Divisions of Geriatric Medicine and Endocrinology, Saint Louis University School of Medicine, St. Louis, Missouri.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25548028

Citation

Woo, Jean, et al. "Defining Sarcopenia in Terms of Incident Adverse Outcomes." Journal of the American Medical Directors Association, vol. 16, no. 3, 2015, pp. 247-52.
Woo J, Leung J, Morley JE. Defining sarcopenia in terms of incident adverse outcomes. J Am Med Dir Assoc. 2015;16(3):247-52.
Woo, J., Leung, J., & Morley, J. E. (2015). Defining sarcopenia in terms of incident adverse outcomes. Journal of the American Medical Directors Association, 16(3), 247-52. https://doi.org/10.1016/j.jamda.2014.11.013
Woo J, Leung J, Morley JE. Defining Sarcopenia in Terms of Incident Adverse Outcomes. J Am Med Dir Assoc. 2015;16(3):247-52. PubMed PMID: 25548028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Defining sarcopenia in terms of incident adverse outcomes. AU - Woo,Jean, AU - Leung,Jason, AU - Morley,J E, Y1 - 2014/12/23/ PY - 2014/09/22/received PY - 2014/11/19/revised PY - 2014/11/19/accepted PY - 2014/12/31/entrez PY - 2014/12/31/pubmed PY - 2016/4/26/medline KW - Sarcopenia KW - appendicular muscle mass KW - grip strength KW - mortality KW - physical limitation KW - walking speed SP - 247 EP - 52 JF - Journal of the American Medical Directors Association JO - J Am Med Dir Assoc VL - 16 IS - 3 N2 - OBJECTIVES: The objectives of this study were to compare the performance of different diagnoses of sarcopenia using European Working Group on Sarcopenia in Older People, International Working Group on Sarcopenia, and the US Foundation of National Institutes of Health (FNIH) criteria, and the screening tool SARC-F, against the Asian Working Group for Sarcopenia consensus panel definitions, in predicting physical limitation, slow walking speed, and repeated chair stand performance, days of hospital stay and mortality at follow up. DESIGN: Longitudinal study. SETTING: Community survey in Hong Kong. PARTICIPANTS: Participants were 4000 men and women 65 years and older living in the community. MEASUREMENTS: Information from questionnaire regarding activities of daily living, physical functioning limitations, and constituent questions of SARC-F; body mass index (BMI), grip strength (GS), walking speed, and appendicular muscle mass (ASM). RESULTS: FNIH, consensus panel definitions, and the screening tool SARC-F all have similar AUC values in predicting incident physical limitation and physical performance measures at 4 years, walking speed at 7 years, days of hospital stay at 7 years, and mortality at 10 years. None of the definitions predicted increase in physical limitation at 4 years or mortality at 10 years in women, and none predicted all the adverse outcomes. The highest AUC values were observed for walking speed at 4 and 7 years. CONCLUSION: When applied to a Chinese elderly population, criteria used for diagnosis of sarcopenia derived from European, Asian, and international consensus panels, from US cutoff values defined from incident physical limitation, and the SARC-F screening tool, all have similar performance in predicting incident physical limitation and mortality. SN - 1538-9375 UR - https://www.unboundmedicine.com/medline/citation/25548028/Defining_sarcopenia_in_terms_of_incident_adverse_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-8610(14)00770-1 DB - PRIME DP - Unbound Medicine ER -