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Prevalence of inadequate vitamin d status and associated factors in children with cystic fibrosis.

Abstract

BACKGROUND

This study aimed to determine the prevalence of inadequate serum 25-hydroxyvitamin D (25(OH)D) levels in a pediatric Canadian cystic fibrosis (CF) population and to assess the effectiveness of a vitamin D supplementation protocol on improving vitamin D status. A secondary objective was to analyze factors that may be associated with inadequate 25(OH)D levels.

METHODS

Vitamin D supplementation, 25(OH)D levels, and factors hypothesized to be associated with 25(OH)D levels were collected through a retrospective chart review (2010 and 2011) of 96 patients (1-18 years) at one CF clinic in Canada. Adequacy of 25(OH)D was set at ≥75 nmol/L. Patients with inadequate 25(OH)D levels in 2010 were prescribed an additional 1000 IU/d for levels <60 nmol/L or 400 IU/d for levels 60-75 nmol/L.

RESULTS

Inadequate 25(OH)D levels were observed in 26% of patients in 2010 and 23% in 2011. After supplementation was increased for those with inadequate 25(OH)D levels in 2010 (n = 20), a significant increase in 25(OH)D levels was observed in 2011 (P = .03). Adequate status was achieved in 50% of these patients (n = 10). Age was significantly negatively associated with 25(OH)D levels in both years (P = .002). Percentage of forced expiratory volume in 1 second was significantly positively associated with 25(OH)D levels in 2011 (P = .03).

CONCLUSION

While vitamin D supplementation was effective at increasing serum 25(OH)D, this protocol did not achieve optimal serum 25(OH)D levels in 25% of the population. Increasing age had the strongest association with 25(OH)D. Current supplementation protocols may require reevaluation based on emerging evidence and revised Cystic Fibrosis Foundation guidelines.

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  • Authors+Show Affiliations

    ,

    Faculty of Agriculture, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada Alberta Health Services, Edmonton, Alberta, Canada.

    ,

    Faculty of Agriculture, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada Alberta Health Services, Edmonton, Alberta, Canada.

    ,

    Alberta Health Services, Edmonton, Alberta, Canada.

    ,

    Faculty of Agriculture, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada.

    ,

    Alberta Health Services, Edmonton, Alberta, Canada.

    Alberta Health Services, Edmonton, Alberta, Canada bodil.larsen@albertahealthservices.ca.

    Source

    MeSH

    Adolescent
    Age Factors
    Canada
    Child
    Child, Preschool
    Cystic Fibrosis
    Dietary Supplements
    Female
    Forced Expiratory Volume
    Humans
    Infant
    Male
    Prevalence
    Retrospective Studies
    Severity of Illness Index
    Treatment Outcome
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25550329

    Citation

    Norton, Laura, et al. "Prevalence of Inadequate Vitamin D Status and Associated Factors in Children With Cystic Fibrosis." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 30, no. 1, 2015, pp. 111-6.
    Norton L, Page S, Sheehan M, et al. Prevalence of inadequate vitamin d status and associated factors in children with cystic fibrosis. Nutr Clin Pract. 2015;30(1):111-6.
    Norton, L., Page, S., Sheehan, M., Mazurak, V., Brunet-Wood, K., & Larsen, B. (2015). Prevalence of inadequate vitamin d status and associated factors in children with cystic fibrosis. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 30(1), pp. 111-6. doi:10.1177/0884533614562839.
    Norton L, et al. Prevalence of Inadequate Vitamin D Status and Associated Factors in Children With Cystic Fibrosis. Nutr Clin Pract. 2015;30(1):111-6. PubMed PMID: 25550329.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of inadequate vitamin d status and associated factors in children with cystic fibrosis. AU - Norton,Laura, AU - Page,Sarah, AU - Sheehan,Melissa, AU - Mazurak,Vera, AU - Brunet-Wood,Kim, AU - Larsen,Bodil, Y1 - 2014/12/30/ PY - 2015/1/1/entrez PY - 2015/1/1/pubmed PY - 2016/1/12/medline KW - cystic fibrosis KW - pediatrics KW - vitamin D KW - vitamin D deficiency SP - 111 EP - 6 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 30 IS - 1 N2 - BACKGROUND: This study aimed to determine the prevalence of inadequate serum 25-hydroxyvitamin D (25(OH)D) levels in a pediatric Canadian cystic fibrosis (CF) population and to assess the effectiveness of a vitamin D supplementation protocol on improving vitamin D status. A secondary objective was to analyze factors that may be associated with inadequate 25(OH)D levels. METHODS: Vitamin D supplementation, 25(OH)D levels, and factors hypothesized to be associated with 25(OH)D levels were collected through a retrospective chart review (2010 and 2011) of 96 patients (1-18 years) at one CF clinic in Canada. Adequacy of 25(OH)D was set at ≥75 nmol/L. Patients with inadequate 25(OH)D levels in 2010 were prescribed an additional 1000 IU/d for levels <60 nmol/L or 400 IU/d for levels 60-75 nmol/L. RESULTS: Inadequate 25(OH)D levels were observed in 26% of patients in 2010 and 23% in 2011. After supplementation was increased for those with inadequate 25(OH)D levels in 2010 (n = 20), a significant increase in 25(OH)D levels was observed in 2011 (P = .03). Adequate status was achieved in 50% of these patients (n = 10). Age was significantly negatively associated with 25(OH)D levels in both years (P = .002). Percentage of forced expiratory volume in 1 second was significantly positively associated with 25(OH)D levels in 2011 (P = .03). CONCLUSION: While vitamin D supplementation was effective at increasing serum 25(OH)D, this protocol did not achieve optimal serum 25(OH)D levels in 25% of the population. Increasing age had the strongest association with 25(OH)D. Current supplementation protocols may require reevaluation based on emerging evidence and revised Cystic Fibrosis Foundation guidelines. SN - 1941-2452 UR - https://www.unboundmedicine.com/medline/citation/25550329/Prevalence_of_inadequate_vitamin_d_status_and_associated_factors_in_children_with_cystic_fibrosis_ L2 - https://doi.org/10.1177/0884533614562839 DB - PRIME DP - Unbound Medicine ER -