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Preoperative serum CA19-9 levels is an independent prognostic factor in patients with resected hilar cholangiocarcinoma.
Int J Clin Exp Pathol. 2014; 7(11):7890-8.IJ

Abstract

To investigate the appropriate cutoff point of CA19-9 for prognosis and other potential prognostic factors that may affect survival of patients with hilar cholangiocarcinoma (HC) after radical surgery. 168 patients who had undergone radical surgery for hilar cholangiocarcinoma and resultant macroscopic curative resection (R0 and R1) were discreetly selected for analyses. Categorized versions were used in univariate model to determine the appropriate cutoff point of CA19-9. CA19-9 and other clinicopathologic factors were analyzed for influence on survival by univariate and multivariate methods. The strongest univariate predictor among the categorized preoperative CA19-9 measures was CA19-9 less than 150 IU/L (P = 0.000). In univariate analysis, tumor size, Bismuth-Corlette classification, portal vein invasion, Lymph node metastasis, resection margin and preoperative CA19-9 levels were identified as significant prognostic factors. In multivariable analysis, lymph node metastasis, resection margin and preoperative CA19-9 levels were independent prognostic factors. our results demonstrated that preoperative CA19-9 levels was also an independent prognostic factor for hilar cholangiocarcinoma, and the most discriminative cutoff point of CA19-9 for prognosis proved to be at 150 U/ml.

Authors+Show Affiliations

Department of Cardio-Thoracic Surgery, Kunming General Hospital of Chengdu Military Region Kunming, China.Department of Neurology, Tangdu Hospital of Fourth Military Medical University Xi'an, China.Department of Pharmacy Surgery, Kunming General Hospital of Chengdu Military Region Kunming, China.Department of Surgery, Chengdu General Hospital of Chengdu Military Region Chengdu, China ; Kunming General Hospital of Chengdu Military Region Kunming, Yunnan, 650000, China.Department of Biliary Surgery, Eastern Hepatobiliary Surgery Hospital of Second Military University Shanghai, China.Department of Biliary Surgery, Eastern Hepatobiliary Surgery Hospital of Second Military University Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25550829

Citation

Cai, Wen-Ke, et al. "Preoperative Serum CA19-9 Levels Is an Independent Prognostic Factor in Patients With Resected Hilar Cholangiocarcinoma." International Journal of Clinical and Experimental Pathology, vol. 7, no. 11, 2014, pp. 7890-8.
Cai WK, Lin JJ, He GH, et al. Preoperative serum CA19-9 levels is an independent prognostic factor in patients with resected hilar cholangiocarcinoma. Int J Clin Exp Pathol. 2014;7(11):7890-8.
Cai, W. K., Lin, J. J., He, G. H., Wang, H., Lu, J. H., & Yang, G. S. (2014). Preoperative serum CA19-9 levels is an independent prognostic factor in patients with resected hilar cholangiocarcinoma. International Journal of Clinical and Experimental Pathology, 7(11), 7890-8.
Cai WK, et al. Preoperative Serum CA19-9 Levels Is an Independent Prognostic Factor in Patients With Resected Hilar Cholangiocarcinoma. Int J Clin Exp Pathol. 2014;7(11):7890-8. PubMed PMID: 25550829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative serum CA19-9 levels is an independent prognostic factor in patients with resected hilar cholangiocarcinoma. AU - Cai,Wen-Ke, AU - Lin,Jia-Ji, AU - He,Gong-Hao, AU - Wang,Hua, AU - Lu,Jun-Hua, AU - Yang,Guang-Shun, Y1 - 2014/10/15/ PY - 2014/09/16/received PY - 2014/11/01/accepted PY - 2015/1/1/entrez PY - 2015/1/1/pubmed PY - 2015/9/5/medline KW - CA19-9 KW - Hilar cholangiocarcinoma KW - cutoff point KW - lymph node metastasis KW - resection margin SP - 7890 EP - 8 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 7 IS - 11 N2 - To investigate the appropriate cutoff point of CA19-9 for prognosis and other potential prognostic factors that may affect survival of patients with hilar cholangiocarcinoma (HC) after radical surgery. 168 patients who had undergone radical surgery for hilar cholangiocarcinoma and resultant macroscopic curative resection (R0 and R1) were discreetly selected for analyses. Categorized versions were used in univariate model to determine the appropriate cutoff point of CA19-9. CA19-9 and other clinicopathologic factors were analyzed for influence on survival by univariate and multivariate methods. The strongest univariate predictor among the categorized preoperative CA19-9 measures was CA19-9 less than 150 IU/L (P = 0.000). In univariate analysis, tumor size, Bismuth-Corlette classification, portal vein invasion, Lymph node metastasis, resection margin and preoperative CA19-9 levels were identified as significant prognostic factors. In multivariable analysis, lymph node metastasis, resection margin and preoperative CA19-9 levels were independent prognostic factors. our results demonstrated that preoperative CA19-9 levels was also an independent prognostic factor for hilar cholangiocarcinoma, and the most discriminative cutoff point of CA19-9 for prognosis proved to be at 150 U/ml. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/25550829/Preoperative_serum_CA19_9_levels_is_an_independent_prognostic_factor_in_patients_with_resected_hilar_cholangiocarcinoma_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25550829/ DB - PRIME DP - Unbound Medicine ER -