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[Visceral leishmaniasis (kala-azar). A rare differential diagnosis of splenomegaly and pancytopenia].
Dtsch Med Wochenschr. 1989 Dec 01; 114(48):1876-81.DM

Abstract

A 53-year-old man developed a septic fever up to 40 degrees C, pancytopenia and hepatosplenomegaly after a holiday in Spain. Administration of piperacillin and amikacin was ineffective, but the fever subsided and partial haematological remission occurred when 1 mg/kg methylprednisolone daily was added. After six months his general condition worsened and pancytopenia with typical inclusion bodies in bone-marrow macrophages was noted, leading to the diagnosis of visceral leishmaniasis (Kala-Azar). The diagnosis was confirmed by serological tests. The causative organism was eliminated and the abnormal findings regressed during treatment with sodium stibogluconate, at first 600 mg/d for two weeks, then 850 mg/d over 16 days, interrupted for 14 days because of side effects.

Authors+Show Affiliations

Baldus M
Medizinische Klinik A, Klinikum der Stadt Ludwigshafen am Rhein.
Schleiffer T
No affiliation info available
Brass H
No affiliation info available

MeSH

Antimony Sodium GluconateDiagnosis, DifferentialHepatomegalyHumansLeishmaniasis, VisceralMaleMiddle AgedPancytopeniaSplenomegalyTravel

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

2555125

Citation

Baldus, M, et al. "[Visceral Leishmaniasis (kala-azar). a Rare Differential Diagnosis of Splenomegaly and Pancytopenia]." Deutsche Medizinische Wochenschrift (1946), vol. 114, no. 48, 1989, pp. 1876-81.
Baldus M, Schleiffer T, Brass H. [Visceral leishmaniasis (kala-azar). A rare differential diagnosis of splenomegaly and pancytopenia]. Dtsch Med Wochenschr. 1989;114(48):1876-81.
Baldus, M., Schleiffer, T., & Brass, H. (1989). [Visceral leishmaniasis (kala-azar). A rare differential diagnosis of splenomegaly and pancytopenia]. Deutsche Medizinische Wochenschrift (1946), 114(48), 1876-81.
Baldus M, Schleiffer T, Brass H. [Visceral Leishmaniasis (kala-azar). a Rare Differential Diagnosis of Splenomegaly and Pancytopenia]. Dtsch Med Wochenschr. 1989 Dec 1;114(48):1876-81. PubMed PMID: 2555125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Visceral leishmaniasis (kala-azar). A rare differential diagnosis of splenomegaly and pancytopenia]. AU - Baldus,M, AU - Schleiffer,T, AU - Brass,H, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 1876 EP - 81 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 114 IS - 48 N2 - A 53-year-old man developed a septic fever up to 40 degrees C, pancytopenia and hepatosplenomegaly after a holiday in Spain. Administration of piperacillin and amikacin was ineffective, but the fever subsided and partial haematological remission occurred when 1 mg/kg methylprednisolone daily was added. After six months his general condition worsened and pancytopenia with typical inclusion bodies in bone-marrow macrophages was noted, leading to the diagnosis of visceral leishmaniasis (Kala-Azar). The diagnosis was confirmed by serological tests. The causative organism was eliminated and the abnormal findings regressed during treatment with sodium stibogluconate, at first 600 mg/d for two weeks, then 850 mg/d over 16 days, interrupted for 14 days because of side effects. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/2555125/[Visceral_leishmaniasis__kala_azar___A_rare_differential_diagnosis_of_splenomegaly_and_pancytopenia]_ DB - PRIME DP - Unbound Medicine ER -