Tags

Type your tag names separated by a space and hit enter

Novel approach of aceclofenac fast dissolving tablet.
Pak J Pharm Sci. 2015 Jan; 28(1):37-41.PJ

Abstract

Fast disintegrating tablets (FDTs) have received ever increasing demand during the last decade, and the field has become a hastily growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Aceclofenac, an NSAID, has been recommended orally for the treatment of bone and connective tissue disorder and thus the formulation of the same resulted in development of several FDT technologies. The present aim is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action: analgesic, antipyretic and anti-inflammatory action. Besides, the conventional tablets also show poor patient compliance an attempt had been made to formulate for FDT of aceclofenac by using various super disintegrants like sodium starch glycolate, croscarmellose sodium and crosspovidone (polyplasdone XL) and PEG 6000 followed by novel technique. The tablets were evaluated for friability, hardness, weight variation, disintegration time, wetting time, in vitro dissolution studies and drug content studies. It was concluded that the batch which was prepared by using combination of crosspovidone and sodium starch glycolate as a super disintegrant shows excellent disintegration time, enhance dissolution rate, taste masking and hence lead to improve efficacy and bioavailability of drug.

Authors+Show Affiliations

Department of Pharmacy, Banasthali University, Rajasthan, India.Department of Pharmacy, Banasthali University, Rajasthan, India.Department of Pharmacy, Banasthali University, Rajasthan, India.Sheffield Hallam University, Howard St, Sheffield, South Yorkshire S1 1WB, UK.Centre of Biotechnology and Microbiology, University of Peshawar, KPK, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25553683

Citation

Dave, Vivek, et al. "Novel Approach of Aceclofenac Fast Dissolving Tablet." Pakistan Journal of Pharmaceutical Sciences, vol. 28, no. 1, 2015, pp. 37-41.
Dave V, Yadav S, Sharma S, et al. Novel approach of aceclofenac fast dissolving tablet. Pak J Pharm Sci. 2015;28(1):37-41.
Dave, V., Yadav, S., Sharma, S., Vishwakarma, P., & Ali, N. (2015). Novel approach of aceclofenac fast dissolving tablet. Pakistan Journal of Pharmaceutical Sciences, 28(1), 37-41.
Dave V, et al. Novel Approach of Aceclofenac Fast Dissolving Tablet. Pak J Pharm Sci. 2015;28(1):37-41. PubMed PMID: 25553683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel approach of aceclofenac fast dissolving tablet. AU - Dave,Vivek, AU - Yadav,Sachdev, AU - Sharma,Swapnil, AU - Vishwakarma,Pushpendra, AU - Ali,Nasir, PY - 2015/1/3/entrez PY - 2015/1/3/pubmed PY - 2015/4/22/medline SP - 37 EP - 41 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 28 IS - 1 N2 - Fast disintegrating tablets (FDTs) have received ever increasing demand during the last decade, and the field has become a hastily growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Aceclofenac, an NSAID, has been recommended orally for the treatment of bone and connective tissue disorder and thus the formulation of the same resulted in development of several FDT technologies. The present aim is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action: analgesic, antipyretic and anti-inflammatory action. Besides, the conventional tablets also show poor patient compliance an attempt had been made to formulate for FDT of aceclofenac by using various super disintegrants like sodium starch glycolate, croscarmellose sodium and crosspovidone (polyplasdone XL) and PEG 6000 followed by novel technique. The tablets were evaluated for friability, hardness, weight variation, disintegration time, wetting time, in vitro dissolution studies and drug content studies. It was concluded that the batch which was prepared by using combination of crosspovidone and sodium starch glycolate as a super disintegrant shows excellent disintegration time, enhance dissolution rate, taste masking and hence lead to improve efficacy and bioavailability of drug. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/25553683/Novel_approach_of_aceclofenac_fast_dissolving_tablet_ DB - PRIME DP - Unbound Medicine ER -