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About the effect of eye blinking on drug release from pHEMA-based hydrogels: an in vitro study.
J Biomater Sci Polym Ed. 2015; 26(4):235-51.JB

Abstract

The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug-loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before. Two poly-2-hydroxyethylmethacrylate-based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. pHEMA-UV revealed some superficial porosity and a lower short-range order than pHEMA-T. We observe that the load and friction cycles enhanced the drug release from pHEMA-UV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, showed that the enhancement of the drug release caused by blinking on this hydrogel may be relevant in in vivo conditions. Conversely, the more sustained drug release from pHEMA-T is not affected by load and friction cycles. The conclusion is that, depending on the physicochemical and microstructural characteristics of the hydrogels, blinking is a factor that may affect the amount of drug delivered to the eye by SCLs and should thus be considered.

Authors+Show Affiliations

a Centro de Química Estrutural, Instituto Superior Técnico , Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa , Portugal.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25555124

Citation

Galante, R, et al. "About the Effect of Eye Blinking On Drug Release From pHEMA-based Hydrogels: an in Vitro Study." Journal of Biomaterials Science. Polymer Edition, vol. 26, no. 4, 2015, pp. 235-51.
Galante R, Paradiso P, Moutinho MG, et al. About the effect of eye blinking on drug release from pHEMA-based hydrogels: an in vitro study. J Biomater Sci Polym Ed. 2015;26(4):235-51.
Galante, R., Paradiso, P., Moutinho, M. G., Fernandes, A. I., Mata, J. L., Matos, A. P., Colaço, R., Saramago, B., & Serro, A. P. (2015). About the effect of eye blinking on drug release from pHEMA-based hydrogels: an in vitro study. Journal of Biomaterials Science. Polymer Edition, 26(4), 235-51. https://doi.org/10.1080/09205063.2014.994948
Galante R, et al. About the Effect of Eye Blinking On Drug Release From pHEMA-based Hydrogels: an in Vitro Study. J Biomater Sci Polym Ed. 2015;26(4):235-51. PubMed PMID: 25555124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - About the effect of eye blinking on drug release from pHEMA-based hydrogels: an in vitro study. AU - Galante,R, AU - Paradiso,P, AU - Moutinho,M G, AU - Fernandes,A I, AU - Mata,J L G, AU - Matos,A P A, AU - Colaço,R, AU - Saramago,B, AU - Serro,A P, Y1 - 2015/01/02/ PY - 2015/1/3/entrez PY - 2015/1/3/pubmed PY - 2015/12/15/medline KW - contact lenses KW - controlled drug release KW - friction KW - levofloxacin KW - pHEMA hydrogels SP - 235 EP - 51 JF - Journal of biomaterials science. Polymer edition JO - J Biomater Sci Polym Ed VL - 26 IS - 4 N2 - The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug-loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before. Two poly-2-hydroxyethylmethacrylate-based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. pHEMA-UV revealed some superficial porosity and a lower short-range order than pHEMA-T. We observe that the load and friction cycles enhanced the drug release from pHEMA-UV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, showed that the enhancement of the drug release caused by blinking on this hydrogel may be relevant in in vivo conditions. Conversely, the more sustained drug release from pHEMA-T is not affected by load and friction cycles. The conclusion is that, depending on the physicochemical and microstructural characteristics of the hydrogels, blinking is a factor that may affect the amount of drug delivered to the eye by SCLs and should thus be considered. SN - 1568-5624 UR - https://www.unboundmedicine.com/medline/citation/25555124/About_the_effect_of_eye_blinking_on_drug_release_from_pHEMA_based_hydrogels:_an_in_vitro_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/09205063.2014.994948 DB - PRIME DP - Unbound Medicine ER -