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Dietary flavonoids intake and the risk of coronary heart disease: a dose-response meta-analysis of 15 prospective studies.

Abstract

INTRODUCTION

Epidemiological studies evaluating the association of flavonoids intake with risk of coronary heart disease (CHD) have produced inconsistent results. We conducted a meta-analysis to summarize the evidence from prospective cohort studies regarding the association between flavonoids intake and risk of CHD.

MATERIALS AND METHODS

Pertinent studies were identified by searching Web of Knowledge, Pubmed and Wan Fang Med Online up to April 2014. Fixed-effect or random-effect model was used to combine the results based on the heterogeneity. Dose-response relationship was assessed by restricted cubic spline. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test.

RESULTS

Fourteen articles with 15 prospective studies involving 7,233 CHD cases and 452,564 participants were included in this meta-analysis. Pooled results suggested that highest flavonoids intake versus lowest intake was significantly associated with the risk of CHD [summary relative risk (RR) = 0.850, 95% confidence interval (CI) = 0.794-0.910, I(2) = 26.0%, τ(2) = 0.041]. Inverse associations were found both in Europe and in USA. Linear dose-response relationship was found between flavonoids intake and CHD risk. However, no significant association was found through the dose-response analysis (an increment of 20 mg/day, summary incidence rate ratios (IRR) = 0.95, 95%CI = 0.88-1.02).

CONCLUSIONS

Our results from this meta-analysis suggested that elevated flavonoids intake might have a protective effect on CHD.

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  • Authors+Show Affiliations

    ,

    Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China.

    ,

    Department of Thoracic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China.

    Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China. Electronic address: hebenheart@sina.com.

    Source

    Thrombosis research 135:3 2015 Mar pg 459-63

    MeSH

    Coronary Disease
    Diet
    Dose-Response Relationship, Drug
    Europe
    Flavonoids
    Humans
    Prospective Studies
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25555317

    Citation

    Jiang, Wenlong, et al. "Dietary Flavonoids Intake and the Risk of Coronary Heart Disease: a Dose-response Meta-analysis of 15 Prospective Studies." Thrombosis Research, vol. 135, no. 3, 2015, pp. 459-63.
    Jiang W, Wei H, He B. Dietary flavonoids intake and the risk of coronary heart disease: a dose-response meta-analysis of 15 prospective studies. Thromb Res. 2015;135(3):459-63.
    Jiang, W., Wei, H., & He, B. (2015). Dietary flavonoids intake and the risk of coronary heart disease: a dose-response meta-analysis of 15 prospective studies. Thrombosis Research, 135(3), pp. 459-63. doi:10.1016/j.thromres.2014.12.016.
    Jiang W, Wei H, He B. Dietary Flavonoids Intake and the Risk of Coronary Heart Disease: a Dose-response Meta-analysis of 15 Prospective Studies. Thromb Res. 2015;135(3):459-63. PubMed PMID: 25555317.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary flavonoids intake and the risk of coronary heart disease: a dose-response meta-analysis of 15 prospective studies. AU - Jiang,Wenlong, AU - Wei,Huabing, AU - He,Ben, Y1 - 2014/12/23/ PY - 2014/09/05/received PY - 2014/11/19/revised PY - 2014/12/09/accepted PY - 2015/1/4/entrez PY - 2015/1/4/pubmed PY - 2015/12/15/medline KW - coronary heart disease KW - dose-response meta-analysis KW - flavonoids intake SP - 459 EP - 63 JF - Thrombosis research JO - Thromb. Res. VL - 135 IS - 3 N2 - INTRODUCTION: Epidemiological studies evaluating the association of flavonoids intake with risk of coronary heart disease (CHD) have produced inconsistent results. We conducted a meta-analysis to summarize the evidence from prospective cohort studies regarding the association between flavonoids intake and risk of CHD. MATERIALS AND METHODS: Pertinent studies were identified by searching Web of Knowledge, Pubmed and Wan Fang Med Online up to April 2014. Fixed-effect or random-effect model was used to combine the results based on the heterogeneity. Dose-response relationship was assessed by restricted cubic spline. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. RESULTS: Fourteen articles with 15 prospective studies involving 7,233 CHD cases and 452,564 participants were included in this meta-analysis. Pooled results suggested that highest flavonoids intake versus lowest intake was significantly associated with the risk of CHD [summary relative risk (RR) = 0.850, 95% confidence interval (CI) = 0.794-0.910, I(2) = 26.0%, τ(2) = 0.041]. Inverse associations were found both in Europe and in USA. Linear dose-response relationship was found between flavonoids intake and CHD risk. However, no significant association was found through the dose-response analysis (an increment of 20 mg/day, summary incidence rate ratios (IRR) = 0.95, 95%CI = 0.88-1.02). CONCLUSIONS: Our results from this meta-analysis suggested that elevated flavonoids intake might have a protective effect on CHD. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/25555317/Dietary_flavonoids_intake_and_the_risk_of_coronary_heart_disease:_a_dose_response_meta_analysis_of_15_prospective_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(14)00685-9 DB - PRIME DP - Unbound Medicine ER -