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Variability in lipid profile among patients presented with acute myocardial infarction, unstable angina and stable angina pectoris.
Eur Rev Med Pharmacol Sci. 2014; 18(24):3761-6.ER

Abstract

OBJECTIVE

Despite the amply evidence and guidelines in treating coronary artery disease (CAD) with lipid-lowering therapy, physicians still have concerns in treating acute myocardial infarction (AMI) patients who have the low serum lipid level. We explored the adequacy of lipid-lowering therapy in treating AMI patients.

PATIENTS AND METHODS

Over 3000 CAD lipid profile data were collected, their data were divided into 3 groups (AMI; stable angina pectoris (SAP) and unstable angina pectoris (UAP) group) based their clinical characteristics. Statistical analyses were performed to compare their baseline lipid levels and clinical feature.

RESULTS

The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) level in AMI patients were the lowest, followed by UAP patient group and SAP patient group. There were significant differences in white blood count (WBC) and ejection fraction (EF) between 3 groups. A good correlation was confirmed between EF% and the lipid parameters of TC, LDL-c, HDL-c, non-HDL-c. WBC did not correlate with the lipid except HDL-c. AMI is an acute inflammatory reaction that is accompanied with the change of lipid level.

CONCLUSIONS

Although the level of TC, LDL-c and HDL-c are lower in AMI, but it is related with acute inflammatory reaction during the rupture of atherosclerotic plaques. Lipid-lowering therapy should not be delayed in treating AMI patients with lower lipid level.

Authors+Show Affiliations

Department of Cardiology, and Department of Cardiology Medicine, Tianjin Chest Hospital, Tianjin, China. qinqin6999@163.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25555864

Citation

Yang, N, et al. "Variability in Lipid Profile Among Patients Presented With Acute Myocardial Infarction, Unstable Angina and Stable Angina Pectoris." European Review for Medical and Pharmacological Sciences, vol. 18, no. 24, 2014, pp. 3761-6.
Yang N, Feng JP, Chen G, et al. Variability in lipid profile among patients presented with acute myocardial infarction, unstable angina and stable angina pectoris. Eur Rev Med Pharmacol Sci. 2014;18(24):3761-6.
Yang, N., Feng, J. P., Chen, G., Kou, L., Li, Y., Ren, P., Zhao, L. L., & Qin, Q. (2014). Variability in lipid profile among patients presented with acute myocardial infarction, unstable angina and stable angina pectoris. European Review for Medical and Pharmacological Sciences, 18(24), 3761-6.
Yang N, et al. Variability in Lipid Profile Among Patients Presented With Acute Myocardial Infarction, Unstable Angina and Stable Angina Pectoris. Eur Rev Med Pharmacol Sci. 2014;18(24):3761-6. PubMed PMID: 25555864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variability in lipid profile among patients presented with acute myocardial infarction, unstable angina and stable angina pectoris. AU - Yang,N, AU - Feng,J-P, AU - Chen,G, AU - Kou,L, AU - Li,Y, AU - Ren,P, AU - Zhao,L-L, AU - Qin,Q, PY - 2015/1/4/entrez PY - 2015/1/6/pubmed PY - 2015/8/19/medline SP - 3761 EP - 6 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 18 IS - 24 N2 - OBJECTIVE: Despite the amply evidence and guidelines in treating coronary artery disease (CAD) with lipid-lowering therapy, physicians still have concerns in treating acute myocardial infarction (AMI) patients who have the low serum lipid level. We explored the adequacy of lipid-lowering therapy in treating AMI patients. PATIENTS AND METHODS: Over 3000 CAD lipid profile data were collected, their data were divided into 3 groups (AMI; stable angina pectoris (SAP) and unstable angina pectoris (UAP) group) based their clinical characteristics. Statistical analyses were performed to compare their baseline lipid levels and clinical feature. RESULTS: The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) level in AMI patients were the lowest, followed by UAP patient group and SAP patient group. There were significant differences in white blood count (WBC) and ejection fraction (EF) between 3 groups. A good correlation was confirmed between EF% and the lipid parameters of TC, LDL-c, HDL-c, non-HDL-c. WBC did not correlate with the lipid except HDL-c. AMI is an acute inflammatory reaction that is accompanied with the change of lipid level. CONCLUSIONS: Although the level of TC, LDL-c and HDL-c are lower in AMI, but it is related with acute inflammatory reaction during the rupture of atherosclerotic plaques. Lipid-lowering therapy should not be delayed in treating AMI patients with lower lipid level. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/25555864/Variability_in_lipid_profile_among_patients_presented_with_acute_myocardial_infarction_unstable_angina_and_stable_angina_pectoris_ L2 - http://www.europeanreview.org/article/8249 DB - PRIME DP - Unbound Medicine ER -