Tags

Type your tag names separated by a space and hit enter

Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles.
Sci Rep. 2015 Jan 05; 5:7561.SR

Abstract

Cardiovascular disease risk is associated with excess body weight and elevated plasma free fatty acid (FFA) concentrations. This study examines how an alternate-day fasting (ADF) diet high (HF) or low (LF) in fat affects plasma FFA profiles in the context of weight loss, and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 women (BMI 30-39.9 kg/m(2)) 25-65 years old were randomized to an 8-week ADF-HF (45% fat) diet or an ADF-LF (25% fat) diet with 25% energy intake on fast days and ad libitum intake on feed days. Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry (DXA). Total and individual FFA and plasma lipid concentrations were measured before and after weight loss. Body weight, BMI, fat mass, total cholesterol, LDL-C and triglyceride concentrations decreased (P < 0.05) in both groups. Total FFA concentrations also decreased (P < 0.001). In the ADF-LF group, decreases were found in several more FFAs than in the ADF-HF group. In the ADF-HF group, FFA concentrations were positively correlated with waist circumference. Depending on the macronutrient composition of a diet, weight loss with an ADF diet decreases FFA concentrations through potentially different mechanisms.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Urbana-Champaign, Chicago, IL, USA.1] Department of Exercise Science, Concordia University, Montreal, QC, Canada [2] Nutrition, Obesity, and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC, Canada.Nutrition, Obesity, and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC, Canada.1] Department of Exercise Science, Concordia University, Montreal, QC, Canada [2] Nutrition, Obesity, and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC, Canada.1] Department of Exercise Science, Concordia University, Montreal, QC, Canada [2] Nutrition, Obesity, and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC, Canada.Department of Kinesiology and Nutrition, University of Illinois at Urbana-Champaign, Chicago, IL, USA.1] Department of Exercise Science, Concordia University, Montreal, QC, Canada [2] Nutrition, Obesity, and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC, Canada.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25557754

Citation

Varady, Krista A., et al. "Effects of Weight Loss Via High Fat Vs. Low Fat Alternate Day Fasting Diets On Free Fatty Acid Profiles." Scientific Reports, vol. 5, 2015, p. 7561.
Varady KA, Dam VT, Klempel MC, et al. Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. Sci Rep. 2015;5:7561.
Varady, K. A., Dam, V. T., Klempel, M. C., Horne, M., Cruz, R., Kroeger, C. M., & Santosa, S. (2015). Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. Scientific Reports, 5, 7561. https://doi.org/10.1038/srep07561
Varady KA, et al. Effects of Weight Loss Via High Fat Vs. Low Fat Alternate Day Fasting Diets On Free Fatty Acid Profiles. Sci Rep. 2015 Jan 5;5:7561. PubMed PMID: 25557754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. AU - Varady,Krista A, AU - Dam,Vi T, AU - Klempel,Monica C, AU - Horne,Matthew, AU - Cruz,Rani, AU - Kroeger,Cynthia M, AU - Santosa,Sylvia, Y1 - 2015/01/05/ PY - 2014/07/11/received PY - 2014/11/26/accepted PY - 2015/1/6/entrez PY - 2015/1/6/pubmed PY - 2015/11/4/medline SP - 7561 EP - 7561 JF - Scientific reports JO - Sci Rep VL - 5 N2 - Cardiovascular disease risk is associated with excess body weight and elevated plasma free fatty acid (FFA) concentrations. This study examines how an alternate-day fasting (ADF) diet high (HF) or low (LF) in fat affects plasma FFA profiles in the context of weight loss, and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 women (BMI 30-39.9 kg/m(2)) 25-65 years old were randomized to an 8-week ADF-HF (45% fat) diet or an ADF-LF (25% fat) diet with 25% energy intake on fast days and ad libitum intake on feed days. Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry (DXA). Total and individual FFA and plasma lipid concentrations were measured before and after weight loss. Body weight, BMI, fat mass, total cholesterol, LDL-C and triglyceride concentrations decreased (P < 0.05) in both groups. Total FFA concentrations also decreased (P < 0.001). In the ADF-LF group, decreases were found in several more FFAs than in the ADF-HF group. In the ADF-HF group, FFA concentrations were positively correlated with waist circumference. Depending on the macronutrient composition of a diet, weight loss with an ADF diet decreases FFA concentrations through potentially different mechanisms. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/25557754/Effects_of_weight_loss_via_high_fat_vs__low_fat_alternate_day_fasting_diets_on_free_fatty_acid_profiles_ L2 - https://doi.org/10.1038/srep07561 DB - PRIME DP - Unbound Medicine ER -