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Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013.

Abstract

BACKGROUND

Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group.

METHODS

During August 2011-May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-year prospective cohort study. Parents were contacted weekly about acute respiratory illness (ARI) in their child. Ill children had combined nasal and throat swabs tested for influenza viruses by real-time reverse transcription-polymerase chain reaction. Influenza vaccination status was verified with vaccination cards. The Cox proportional hazards approach was used to estimate hazard ratios. Vaccine effectiveness (VE) was estimated as 100% x (1-hazard ratio).

RESULTS

During 2011-2013, 968 children were enrolled (median age, 10·3 months); 948 (97·9%) had a vaccination record and were included. Of these, 394 (41·6%) had ≥1 medical conditions. Vaccination coverage for the 2011-2012 and 2012-2013 seasons was 29·3% (93/317) and 30·0% (197/656), respectively. In 2011-2012, there were 213 ARI episodes, of which 10 (4·6%) were influenza positive (2·3 per 1000 vaccinated and 3·8 per 1000 unvaccinated child-weeks). The VE was 55% (95% confidence interval [CI], -72, 88). In 2012-2013, there were 846 ARIs, of which 52 (6·2%) were influenza positive (1·8 per 1000 vaccinated and 4·5 per 1000 unvaccinated child-weeks). The VE was 64% (CI, 13%, 85%).

CONCLUSION

Influenza vaccination coverage among young children in Thailand was low, although vaccination was moderately effective. Continued efforts are needed to increase influenza vaccination coverage and evaluate VE among young children in Thailand.

Authors+Show Affiliations

Influenza Program, Thailand Ministry of Public Health - U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25557920

Citation

Kittikraisak, Wanitchaya, et al. "Influenza Vaccination Coverage and Effectiveness in Young Children in Thailand, 2011-2013." Influenza and Other Respiratory Viruses, vol. 9, no. 2, 2015, pp. 85-93.
Kittikraisak W, Suntarattiwong P, Levy J, et al. Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013. Influenza Other Respir Viruses. 2015;9(2):85-93.
Kittikraisak, W., Suntarattiwong, P., Levy, J., Fernandez, S., Dawood, F. S., Olsen, S. J., & Chotpitayasunondh, T. (2015). Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013. Influenza and Other Respiratory Viruses, 9(2), pp. 85-93. doi:10.1111/irv.12302.
Kittikraisak W, et al. Influenza Vaccination Coverage and Effectiveness in Young Children in Thailand, 2011-2013. Influenza Other Respir Viruses. 2015;9(2):85-93. PubMed PMID: 25557920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccination coverage and effectiveness in young children in Thailand, 2011-2013. AU - Kittikraisak,Wanitchaya, AU - Suntarattiwong,Piyarat, AU - Levy,Jens, AU - Fernandez,Stefan, AU - Dawood,Fatimah S, AU - Olsen,Sonja J, AU - Chotpitayasunondh,Tawee, Y1 - 2015/01/05/ PY - 2014/12/05/accepted PY - 2015/1/6/entrez PY - 2015/1/6/pubmed PY - 2015/8/14/medline KW - Influenza KW - Thailand KW - children KW - coverage KW - effectiveness KW - vaccination SP - 85 EP - 93 JF - Influenza and other respiratory viruses JO - Influenza Other Respir Viruses VL - 9 IS - 2 N2 - BACKGROUND: Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group. METHODS: During August 2011-May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-year prospective cohort study. Parents were contacted weekly about acute respiratory illness (ARI) in their child. Ill children had combined nasal and throat swabs tested for influenza viruses by real-time reverse transcription-polymerase chain reaction. Influenza vaccination status was verified with vaccination cards. The Cox proportional hazards approach was used to estimate hazard ratios. Vaccine effectiveness (VE) was estimated as 100% x (1-hazard ratio). RESULTS: During 2011-2013, 968 children were enrolled (median age, 10·3 months); 948 (97·9%) had a vaccination record and were included. Of these, 394 (41·6%) had ≥1 medical conditions. Vaccination coverage for the 2011-2012 and 2012-2013 seasons was 29·3% (93/317) and 30·0% (197/656), respectively. In 2011-2012, there were 213 ARI episodes, of which 10 (4·6%) were influenza positive (2·3 per 1000 vaccinated and 3·8 per 1000 unvaccinated child-weeks). The VE was 55% (95% confidence interval [CI], -72, 88). In 2012-2013, there were 846 ARIs, of which 52 (6·2%) were influenza positive (1·8 per 1000 vaccinated and 4·5 per 1000 unvaccinated child-weeks). The VE was 64% (CI, 13%, 85%). CONCLUSION: Influenza vaccination coverage among young children in Thailand was low, although vaccination was moderately effective. Continued efforts are needed to increase influenza vaccination coverage and evaluate VE among young children in Thailand. SN - 1750-2659 UR - https://www.unboundmedicine.com/medline/citation/25557920/Influenza_vaccination_coverage_and_effectiveness_in_young_children_in_Thailand_2011_2013_ L2 - https://doi.org/10.1111/irv.12302 DB - PRIME DP - Unbound Medicine ER -