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Effects of dietary polyunsaturated fatty acid on platelet aggregation in rats.
Proc Natl Sci Counc Repub China B. 1989 Apr; 13(2):102-8.PN

Abstract

In the present study, we changed the fatty acid profile in blood and platelet membranes by dietary manipulation, and examined the effect on platelet aggregation in rats. Fifty-five rats were divided into five groups and fed for 56 days with 1% cholesterol and different types of fatty acid-rich diets: basal, lard, lard + fish oil, soybean oil, and soybean oil + fish oil. a decrease in serum arachidonic acid (20:4, omega-6, AA) and an increase in serum eicosapentaenoic acid (20:5, omega-3, EPA) were found in all experimental dietary groups fed with refined fish oil. Similar changes in the polyunsaturated fatty acids were also found in the platelet membrane phospholipids. Platelet aggregation, quantitated by the slope and height of the aggregation curve induced by different concentrations of ADP in a platelet aggregometer, was inhibited in all groups fed with refined fish oil. This inhibition of platelet aggregation may be related to an increase in the ratio of EPA and AA in the platelet membrane phospholipids after dietary manipulation. The differences in the platelet aggregation and thromboxane B2 (TXB2) concentration between the lard and the lard + fish oil groups were more profound than that between the soybean oil and the soybean oil + fish oil group. However, the malondialdehyde (MDA) concentration revealed no significant differences between the five groups.

Authors+Show Affiliations

Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2555829

Citation

Ding, Y A., et al. "Effects of Dietary Polyunsaturated Fatty Acid On Platelet Aggregation in Rats." Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, vol. 13, no. 2, 1989, pp. 102-8.
Ding YA, Chang WK, Chen ML. Effects of dietary polyunsaturated fatty acid on platelet aggregation in rats. Proc Natl Sci Counc Repub China B. 1989;13(2):102-8.
Ding, Y. A., Chang, W. K., & Chen, M. L. (1989). Effects of dietary polyunsaturated fatty acid on platelet aggregation in rats. Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 13(2), 102-8.
Ding YA, Chang WK, Chen ML. Effects of Dietary Polyunsaturated Fatty Acid On Platelet Aggregation in Rats. Proc Natl Sci Counc Repub China B. 1989;13(2):102-8. PubMed PMID: 2555829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary polyunsaturated fatty acid on platelet aggregation in rats. AU - Ding,Y A, AU - Chang,W K, AU - Chen,M L, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 102 EP - 8 JF - Proceedings of the National Science Council, Republic of China. Part B, Life sciences JO - Proc Natl Sci Counc Repub China B VL - 13 IS - 2 N2 - In the present study, we changed the fatty acid profile in blood and platelet membranes by dietary manipulation, and examined the effect on platelet aggregation in rats. Fifty-five rats were divided into five groups and fed for 56 days with 1% cholesterol and different types of fatty acid-rich diets: basal, lard, lard + fish oil, soybean oil, and soybean oil + fish oil. a decrease in serum arachidonic acid (20:4, omega-6, AA) and an increase in serum eicosapentaenoic acid (20:5, omega-3, EPA) were found in all experimental dietary groups fed with refined fish oil. Similar changes in the polyunsaturated fatty acids were also found in the platelet membrane phospholipids. Platelet aggregation, quantitated by the slope and height of the aggregation curve induced by different concentrations of ADP in a platelet aggregometer, was inhibited in all groups fed with refined fish oil. This inhibition of platelet aggregation may be related to an increase in the ratio of EPA and AA in the platelet membrane phospholipids after dietary manipulation. The differences in the platelet aggregation and thromboxane B2 (TXB2) concentration between the lard and the lard + fish oil groups were more profound than that between the soybean oil and the soybean oil + fish oil group. However, the malondialdehyde (MDA) concentration revealed no significant differences between the five groups. SN - 0255-6596 UR - https://www.unboundmedicine.com/medline/citation/2555829/Effects_of_dietary_polyunsaturated_fatty_acid_on_platelet_aggregation_in_rats_ L2 - https://antibodies.cancer.gov/detail/CPTC-TIMP1-2 DB - PRIME DP - Unbound Medicine ER -