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Impact of nonaspirin nonsteroidal anti-inflammatory agents and acetaminophen on sensorineural hearing loss: a systematic review.
Otolaryngol Head Neck Surg. 2015 Mar; 152(3):393-409.OH

Abstract

OBJECTIVE

To perform a systematic review evaluating the association between sensorineural hearing loss and (1) nonsteroidal anti-inflammatory drugs (NSAIDs) as a class, (2) NSAIDs available over the counter, (3) NSAIDs in short intravenous courses, (4) prescription NSAIDs utilized by patients without systemic inflammatory conditions, (5) prescription NSAIDs in patients with arthritides, and (6) acetaminophen with and without concomitant narcotic usage.

DATA SOURCES

Computerized searches of PubMed, EMBASE, and the Cochrane Library were updated through May 2014, along with manual searches and inquiries to topic experts.

REVIEW METHODS

The systematic review was performed according to an a priori protocol. Data extraction was performed by 2 independent investigators, and it focused on relevant audiologic measurements, methodological elements related to risk of bias, and potential confounders.

RESULTS

The 23 criterion-meeting studies included a total of 92,532 participants, with mixed results. Sulindac was the only specific agent to have been studied with formal audiometry in a randomized double-blind placebo-controlled trial in which hearing was the reported primary outcome: Although an effect was seen in the unadjusted analysis (pure tone threshold>15 dB, 9.3% vs 2.9%; relative risk [RR], 3.2; confidence interval [CI], 1.09-9.55; P=.02), the effect dissipated in the adjusted analysis (P=.09). There was a significant effect on self-reported hearing loss from NSAIDs as a class (RR, 1.21; CI, 1.11-1.33), ibuprofen (RR, 1.13; CI, 1.06-1.19), and acetaminophen (RR, 1.21; CI, 1.11-1.33), but no formal audiometric data confirm or refute this suggested effect. Audiometry has demonstrated profound loss in some instances of acetaminophen-narcotic combination ingestions.

CONCLUSIONS

Data are varied regarding the impact of NSAIDs and acetaminophen on population hearing health.

Authors+Show Affiliations

Harvard Medical School, Boston, Massachusetts.Texas Tech Health Sciences Center, Lubbock, Texas.Harvard Medical School, Boston, Massachusetts jennifer_shin@meei.harvard.edu.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

25560405

Citation

Kyle, Meghann E., et al. "Impact of Nonaspirin Nonsteroidal Anti-inflammatory Agents and Acetaminophen On Sensorineural Hearing Loss: a Systematic Review." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 152, no. 3, 2015, pp. 393-409.
Kyle ME, Wang JC, Shin JJ. Impact of nonaspirin nonsteroidal anti-inflammatory agents and acetaminophen on sensorineural hearing loss: a systematic review. Otolaryngol Head Neck Surg. 2015;152(3):393-409.
Kyle, M. E., Wang, J. C., & Shin, J. J. (2015). Impact of nonaspirin nonsteroidal anti-inflammatory agents and acetaminophen on sensorineural hearing loss: a systematic review. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 152(3), 393-409. https://doi.org/10.1177/0194599814564533
Kyle ME, Wang JC, Shin JJ. Impact of Nonaspirin Nonsteroidal Anti-inflammatory Agents and Acetaminophen On Sensorineural Hearing Loss: a Systematic Review. Otolaryngol Head Neck Surg. 2015;152(3):393-409. PubMed PMID: 25560405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of nonaspirin nonsteroidal anti-inflammatory agents and acetaminophen on sensorineural hearing loss: a systematic review. AU - Kyle,Meghann E, AU - Wang,James C, AU - Shin,Jennifer J, Y1 - 2015/01/05/ PY - 2015/1/7/entrez PY - 2015/1/7/pubmed PY - 2015/6/24/medline KW - acetaminophen KW - diflunisal KW - fenoprofen KW - hearing loss KW - ibuprofen KW - indomethacin KW - ketorolac KW - naproxen KW - nonsteroidal anti-inflammatory drugs KW - piroxicam KW - pirprofen KW - sulindac SP - 393 EP - 409 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 152 IS - 3 N2 - OBJECTIVE: To perform a systematic review evaluating the association between sensorineural hearing loss and (1) nonsteroidal anti-inflammatory drugs (NSAIDs) as a class, (2) NSAIDs available over the counter, (3) NSAIDs in short intravenous courses, (4) prescription NSAIDs utilized by patients without systemic inflammatory conditions, (5) prescription NSAIDs in patients with arthritides, and (6) acetaminophen with and without concomitant narcotic usage. DATA SOURCES: Computerized searches of PubMed, EMBASE, and the Cochrane Library were updated through May 2014, along with manual searches and inquiries to topic experts. REVIEW METHODS: The systematic review was performed according to an a priori protocol. Data extraction was performed by 2 independent investigators, and it focused on relevant audiologic measurements, methodological elements related to risk of bias, and potential confounders. RESULTS: The 23 criterion-meeting studies included a total of 92,532 participants, with mixed results. Sulindac was the only specific agent to have been studied with formal audiometry in a randomized double-blind placebo-controlled trial in which hearing was the reported primary outcome: Although an effect was seen in the unadjusted analysis (pure tone threshold>15 dB, 9.3% vs 2.9%; relative risk [RR], 3.2; confidence interval [CI], 1.09-9.55; P=.02), the effect dissipated in the adjusted analysis (P=.09). There was a significant effect on self-reported hearing loss from NSAIDs as a class (RR, 1.21; CI, 1.11-1.33), ibuprofen (RR, 1.13; CI, 1.06-1.19), and acetaminophen (RR, 1.21; CI, 1.11-1.33), but no formal audiometric data confirm or refute this suggested effect. Audiometry has demonstrated profound loss in some instances of acetaminophen-narcotic combination ingestions. CONCLUSIONS: Data are varied regarding the impact of NSAIDs and acetaminophen on population hearing health. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/25560405/Impact_of_nonaspirin_nonsteroidal_anti_inflammatory_agents_and_acetaminophen_on_sensorineural_hearing_loss:_a_systematic_review_ L2 - https://journals.sagepub.com/doi/10.1177/0194599814564533?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -