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The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy.
Pharmacol Ther 2015; 149:191-212P&T

Abstract

Over the past recent years, a great number of studies have been directed toward the evaluation of the human host-gut microbiota interaction, with the goal to progress the understanding of the etiology of several complex diseases. Alterations in the intestinal microbiota associated with inflammatory bowel disease are well supported by literature data and have been widely accepted by the research community. The concomitant implementation of high-throughput sequencing techniques to analyze and characterize the composition of the intestinal microbiota has reinforced the view that inflammatory bowel disease results from altered interactions between gut microbes and the mucosal immune system and has raised the possibility that some form of modulation of the intestinal microbiota may constitute a potential therapeutic basis for the disease. The aim of this review is to describe the changes of gut microbiota in inflammatory bowel disease, focusing the attention on its involvement in the pathogenesis of the disease, and to review and discuss the therapeutic potential to modify the intestinal microbial population with antibiotics, probiotics, prebiotics, synbiotics and fecal microbiota transplantation.

Authors+Show Affiliations

Department of Medical Sciences, Division of Internal Medicine and Gastroenterology, A. Gemelli Hospital, Rome, Italy. Electronic address: gcammarota@rm.unicatt.it.Department of Medical Sciences, Division of Internal Medicine and Gastroenterology, A. Gemelli Hospital, Rome, Italy.Department of Medical Sciences, Division of Internal Medicine and Gastroenterology, A. Gemelli Hospital, Rome, Italy.Department of Medical Sciences, Division of Internal Medicine and Gastroenterology, A. Gemelli Hospital, Rome, Italy.Department of Medical Sciences, Division of Internal Medicine and Gastroenterology, A. Gemelli Hospital, Rome, Italy.Institute of Pharmacology, Catholic University, School of Medicine and Surgery, A. Gemelli Hospital, Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25561343

Citation

Cammarota, Giovanni, et al. "The Involvement of Gut Microbiota in Inflammatory Bowel Disease Pathogenesis: Potential for Therapy." Pharmacology & Therapeutics, vol. 149, 2015, pp. 191-212.
Cammarota G, Ianiro G, Cianci R, et al. The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy. Pharmacol Ther. 2015;149:191-212.
Cammarota, G., Ianiro, G., Cianci, R., Bibbò, S., Gasbarrini, A., & Currò, D. (2015). The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy. Pharmacology & Therapeutics, 149, pp. 191-212. doi:10.1016/j.pharmthera.2014.12.006.
Cammarota G, et al. The Involvement of Gut Microbiota in Inflammatory Bowel Disease Pathogenesis: Potential for Therapy. Pharmacol Ther. 2015;149:191-212. PubMed PMID: 25561343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy. AU - Cammarota,Giovanni, AU - Ianiro,Gianluca, AU - Cianci,Rossella, AU - Bibbò,Stefano, AU - Gasbarrini,Antonio, AU - Currò,Diego, Y1 - 2015/01/03/ PY - 2014/07/29/received PY - 2014/12/29/accepted PY - 2015/1/7/entrez PY - 2015/1/7/pubmed PY - 2015/12/17/medline KW - Fecal microbiota transplantation KW - Gut microbiota KW - Inflammatory bowel disease KW - Metagenomics KW - Probiotics KW - Therapy SP - 191 EP - 212 JF - Pharmacology & therapeutics JO - Pharmacol. Ther. VL - 149 N2 - Over the past recent years, a great number of studies have been directed toward the evaluation of the human host-gut microbiota interaction, with the goal to progress the understanding of the etiology of several complex diseases. Alterations in the intestinal microbiota associated with inflammatory bowel disease are well supported by literature data and have been widely accepted by the research community. The concomitant implementation of high-throughput sequencing techniques to analyze and characterize the composition of the intestinal microbiota has reinforced the view that inflammatory bowel disease results from altered interactions between gut microbes and the mucosal immune system and has raised the possibility that some form of modulation of the intestinal microbiota may constitute a potential therapeutic basis for the disease. The aim of this review is to describe the changes of gut microbiota in inflammatory bowel disease, focusing the attention on its involvement in the pathogenesis of the disease, and to review and discuss the therapeutic potential to modify the intestinal microbial population with antibiotics, probiotics, prebiotics, synbiotics and fecal microbiota transplantation. SN - 1879-016X UR - https://www.unboundmedicine.com/medline/citation/25561343/The_involvement_of_gut_microbiota_in_inflammatory_bowel_disease_pathogenesis:_potential_for_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-7258(14)00235-6 DB - PRIME DP - Unbound Medicine ER -