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Norovirus.
Clin Microbiol Rev. 2015 Jan; 28(1):134-64.CM

Abstract

Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen that causes substantial morbidity across both health care and community settings. Several factors enhance the transmissibility of norovirus, including the small inoculum required to produce infection (<100 viral particles), prolonged viral shedding, and its ability to survive in the environment. In this review, we describe the basic virology and immunology of noroviruses, the clinical disease resulting from infection and its diagnosis and management, as well as host and pathogen factors that complicate vaccine development. Additionally, we discuss overall epidemiology, infection control strategies, and global reporting efforts aimed at controlling this worldwide cause of acute gastroenteritis. Prompt implementation of infection control measures remains the mainstay of norovirus outbreak management.

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Authors+Show Affiliations

Robilotti E
Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.
Deresinski S
Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.
Pinsky BA
Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA Department of Pathology, Stanford University School of Medicine, Stanford, California, USA bpinsky@stanford.edu.

MeSH

Caliciviridae InfectionsDisease NotificationGastroenteritisHost-Pathogen InteractionsNorovirusViral Vaccines

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25567225

Citation

Robilotti, Elizabeth, et al. "Norovirus." Clinical Microbiology Reviews, vol. 28, no. 1, 2015, pp. 134-64.
Robilotti E, Deresinski S, Pinsky BA. Norovirus. Clin Microbiol Rev. 2015;28(1):134-64.
Robilotti, E., Deresinski, S., & Pinsky, B. A. (2015). Norovirus. Clinical Microbiology Reviews, 28(1), 134-64. https://doi.org/10.1128/CMR.00075-14
Robilotti E, Deresinski S, Pinsky BA. Norovirus. Clin Microbiol Rev. 2015;28(1):134-64. PubMed PMID: 25567225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Norovirus. AU - Robilotti,Elizabeth, AU - Deresinski,Stan, AU - Pinsky,Benjamin A, PY - 2015/1/9/entrez PY - 2015/1/9/pubmed PY - 2015/6/10/medline SP - 134 EP - 64 JF - Clinical microbiology reviews JO - Clin Microbiol Rev VL - 28 IS - 1 N2 - Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen that causes substantial morbidity across both health care and community settings. Several factors enhance the transmissibility of norovirus, including the small inoculum required to produce infection (<100 viral particles), prolonged viral shedding, and its ability to survive in the environment. In this review, we describe the basic virology and immunology of noroviruses, the clinical disease resulting from infection and its diagnosis and management, as well as host and pathogen factors that complicate vaccine development. Additionally, we discuss overall epidemiology, infection control strategies, and global reporting efforts aimed at controlling this worldwide cause of acute gastroenteritis. Prompt implementation of infection control measures remains the mainstay of norovirus outbreak management. SN - 1098-6618 UR - https://www.unboundmedicine.com/medline/citation/25567225/Norovirus_ DB - PRIME DP - Unbound Medicine ER -