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An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis.
Eur J Pediatr. 2015 Jul; 174(7):903-10.EJ

Abstract

The link between Helicobacter pylori and iron deficiency (ID) or iron deficiency anemia (IDA) has been investigated recently. We suggested that IDA/ID associated with H. pylori infection might be mediated by inflammation-driven hepcidin production. Patients with complaints of recurrent abdominal pain and dyspepsia aged between 7-16 years were included in this study. Patients were divided into two groups according to H. pylori status in upper gastrointestinal endoscopy. Group I who had H. pylori gastritis (n=50) received triple antibiotic therapy. Group II (n=50) who had H. pylori-negative gastritis only received proton pump inhibitor. Thirty healthy children with the similar age and gender were included in the study as a control group. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, prohepcidin and interleukin-6 (IL-6) values were evaluated in all children at the first visit. Initial tests were repeated after H. pylori eradication. Initial levels of ferritin (p=0.002), prohepcidin (p=0.003), and IL-6 (p=0.004) were found significantly lower in group I compared to group II and the control group. The mean prohepcidin level was lower in the anemic H. pylori-positive group than in non-anemic H. pylori-positive group; however, the difference was not statistically significant. While significant increases in hematocrit and mean corpuscular volume were observed, no significant difference was found in serum ferritin, prohepcidin, or IL-6 level after eradication treatment in H. pylori-positive group.

CONCLUSION

H. pylori-induced gastritis appears to cause an increase in prohepcidin levels and a decrease in ferritin levels, supporting our hypothesis; but this relationship has not been proven.

Authors+Show Affiliations

Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkey, drnagehan@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25567795

Citation

Emiralioglu, Nagehan, et al. "An Insight Into the Relationships Between Prohepcidin, Iron Deficiency Anemia, and Interleukin-6 Values in Pediatric Helicobacter Pylori Gastritis." European Journal of Pediatrics, vol. 174, no. 7, 2015, pp. 903-10.
Emiralioglu N, Yenicesu I, Sari S, et al. An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis. Eur J Pediatr. 2015;174(7):903-10.
Emiralioglu, N., Yenicesu, I., Sari, S., Egritas, O., Poyraz, A., Pasaoglu, O. T., Celik, B., & Dalgic, B. (2015). An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis. European Journal of Pediatrics, 174(7), 903-10. https://doi.org/10.1007/s00431-014-2482-4
Emiralioglu N, et al. An Insight Into the Relationships Between Prohepcidin, Iron Deficiency Anemia, and Interleukin-6 Values in Pediatric Helicobacter Pylori Gastritis. Eur J Pediatr. 2015;174(7):903-10. PubMed PMID: 25567795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis. AU - Emiralioglu,Nagehan, AU - Yenicesu,Idil, AU - Sari,Sinan, AU - Egritas,Odul, AU - Poyraz,Aylar, AU - Pasaoglu,Ozge Tugce, AU - Celik,Bulent, AU - Dalgic,Buket, Y1 - 2015/01/09/ PY - 2014/07/19/received PY - 2014/11/21/accepted PY - 2014/10/21/revised PY - 2015/1/9/entrez PY - 2015/1/9/pubmed PY - 2016/3/2/medline SP - 903 EP - 10 JF - European journal of pediatrics JO - Eur J Pediatr VL - 174 IS - 7 N2 - UNLABELLED: The link between Helicobacter pylori and iron deficiency (ID) or iron deficiency anemia (IDA) has been investigated recently. We suggested that IDA/ID associated with H. pylori infection might be mediated by inflammation-driven hepcidin production. Patients with complaints of recurrent abdominal pain and dyspepsia aged between 7-16 years were included in this study. Patients were divided into two groups according to H. pylori status in upper gastrointestinal endoscopy. Group I who had H. pylori gastritis (n=50) received triple antibiotic therapy. Group II (n=50) who had H. pylori-negative gastritis only received proton pump inhibitor. Thirty healthy children with the similar age and gender were included in the study as a control group. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, prohepcidin and interleukin-6 (IL-6) values were evaluated in all children at the first visit. Initial tests were repeated after H. pylori eradication. Initial levels of ferritin (p=0.002), prohepcidin (p=0.003), and IL-6 (p=0.004) were found significantly lower in group I compared to group II and the control group. The mean prohepcidin level was lower in the anemic H. pylori-positive group than in non-anemic H. pylori-positive group; however, the difference was not statistically significant. While significant increases in hematocrit and mean corpuscular volume were observed, no significant difference was found in serum ferritin, prohepcidin, or IL-6 level after eradication treatment in H. pylori-positive group. CONCLUSION: H. pylori-induced gastritis appears to cause an increase in prohepcidin levels and a decrease in ferritin levels, supporting our hypothesis; but this relationship has not been proven. SN - 1432-1076 UR - https://www.unboundmedicine.com/medline/citation/25567795/An_insight_into_the_relationships_between_prohepcidin_iron_deficiency_anemia_and_interleukin_6_values_in_pediatric_Helicobacter_pylori_gastritis_ L2 - https://dx.doi.org/10.1007/s00431-014-2482-4 DB - PRIME DP - Unbound Medicine ER -